抑郁症和双相情感障碍中的松果体体积。,Frontiers in Psychiatry

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抑郁症和双相情感障碍中的松果体体积。
Frontiers in Psychiatry ( IF 3.2 ) Pub Date : 2020-05-20 , DOI: 10.3389/fpsyt.2020.00450
Tsutomu Takahashi ₁ , Daiki Sasabayashi ₁ , Murat Yücel ₂ , Sarah Whittle ₃ , Valentina Lorenzetti ₄ , Mark Walterfang _{3,

5,

6} , Michio Suzuki ₁ , Christos Pantelis ₃ , Gin S Malhi _{7,

8} , Nicholas B Allen ₉

Affiliation

褪黑素分泌异常已在患有情感障碍如重度抑郁症（MDD）和双相情感障碍（BD）的患者中得到证实。然而，在这些患者中，磁共振成像（MRI）研究以前曾研究过松果体的体积，该体积通过分泌褪黑激素来调节昼夜节律，但发现不一致。本研究采用MRI检查了56例MDD患者（29名当前抑郁患者和27例缓解患者），26例BD患者以及相匹配的对照者（33例MDD和24例BD）的松果体体积和松果囊肿患病率。当前MDD，缓解的MDD和BD组的松果体积和囊肿患病率与健康对照组没有显着差异。然而，当前的非忧郁抑郁症MDD亚组的松果体体积明显小于忧郁MDD亚组的松果体体积。有趣的是，在当前的MDD组中，松果体体积与失去兴趣的严重程度呈负相关。药物治疗和情感发作的次数与MDD或BD组的松果体数量无关。尽管这些结果并不表明松果体的体积反映了情感障碍中褪黑激素的异常分泌，但它们确实指出了松果体异常与MDD的临床亚型及其症状相关的可能性。药物治疗和情感发作的次数与MDD或BD组的松果体数量无关。尽管这些结果并不表明松果体的体积反映了情感障碍中褪黑激素的异常分泌，但它们确实指出了松果体异常与MDD的临床亚型及其症状相关的可能性。药物治疗和情感发作的次数与MDD或BD组的松果体数量无关。尽管这些结果并不表明松果体的体积反映了情感障碍中褪黑激素的异常分泌，但它们确实指出了松果体异常与MDD的临床亚型及其症状相关的可能性。

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Pineal Gland Volume in Major Depressive and Bipolar Disorders.

Abnormal melatonin secretion has been demonstrated in patients with affective disorders such as major depressive disorder (MDD) and bipolar disorder (BD). However, magnetic resonance imaging (MRI) studies that previously investigated the volume of the pineal gland, which regulates circadian rhythms by secreting melatonin, in these patients reported inconsistent findings. The present study employed MRI to examine pineal gland volumes and pineal cyst prevalence in 56 MDD patients (29 currently depressed and 27 remitted patients), 26 BD patients, and matched controls (33 for MDD and 24 for BD). Pineal volumes and cyst prevalence in the current MDD, remitted MDD, and BD groups did not significantly differ from those of the healthy controls. However, pineal gland volumes were significantly smaller in the current MDD subgroup of non-melancholic depression than in the melancholic MDD subgroup. Interestingly, pineal volumes correlated negatively with the severity of loss of interest in the current MDD group. Medication and the number of affective episodes were not associated with pineal volumes in the MDD or BD group. While these results do not suggest that pineal volumes reflect abnormal melatonin secretion in affective disorders, they do point to the possibility that pineal abnormalities are associated with clinical subtypes of MDD and its symptomatology.

更新日期：2020-05-20

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