Ethaninidothioic acid (R5421) is not a selective inhibitor of platelet phospholipid scramblase activity.,British Journal of Pharmacology

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Ethaninidothioic acid (R5421) is not a selective inhibitor of platelet phospholipid scramblase activity.
British Journal of Pharmacology ( IF 6.8 ) Pub Date : 2020-06-04 , DOI: 10.1111/bph.15152
Sarah Louise Millington-Burgess ₁ , Arkadiusz M Bonna ₂ , Taufiq Rahman ₁ , Matthew Thomas Harper ₁

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Ethaninidothioic acid (R5421) has been used as a scramblase inhibitor to determine the role of phospholipid scrambling across a range of systems including platelet procoagulant activity. The selectivity of R5421 has not been thoroughly studied. Here, we characterised the effects of R5421 on platelet function and its suitability for use as a scramblase inhibitor.

中文翻译：

乙氨基硫氰酸（R5421）不是血小板磷脂scramblase活性的选择性抑制剂。

乙硫基乙醇酸（R5421）已被用作扰乱酶抑制剂，以确定磷脂扰乱在包括血小板促凝活性在内的一系列系统中的作用。R5421的选择性尚未得到充分研究。在这里，我们表征了R5421对血小板功能的影响及其适合用作scramblase抑制剂的能力。

更新日期：2020-06-04

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