Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Effects of Inulin Propionate Ester on Obesity-Related Metabolic Syndrome and Intestinal Microbial Homeostasis in Diet-Induced Obese Mice.
ACS Omega ( IF 3.7 ) Pub Date : 2020-05-28 , DOI: 10.1021/acsomega.0c00649 Xiaozhen Zhu 1, 2 , Xia Zhang 1, 2 , Xuelu Gao 2, 3 , Yuetao Yi 1, 4 , Yang Hou 5 , Xianyao Meng 1, 2 , Chenchen Jia 1, 2 , Bo Chao 6 , Wenyong Fan 6 , Xinrui Li 6 , Hanhan Zhang 7
ACS Omega ( IF 3.7 ) Pub Date : 2020-05-28 , DOI: 10.1021/acsomega.0c00649 Xiaozhen Zhu 1, 2 , Xia Zhang 1, 2 , Xuelu Gao 2, 3 , Yuetao Yi 1, 4 , Yang Hou 5 , Xianyao Meng 1, 2 , Chenchen Jia 1, 2 , Bo Chao 6 , Wenyong Fan 6 , Xinrui Li 6 , Hanhan Zhang 7
Affiliation
|
Short-chain fatty acid (SCFA) plays an important role in improving obesity and related metabolic syndrome induced by high-fat diet. We used the prepared inulin propionate ester (IPE) as a system for the targeted release of propionate to the colon to elucidate the role of IPE in regulating obesity and metabolic syndrome, and intestinal microbial homeostasis, in diet-induced obese mice. With this strategy, IPE significantly increased the SCFA contents in the colon and resulted in significant body weight reduction, insulin resistance amelioration, and gastrointestinal hormone (glucagon-like peptide and peptide YY) secretion (P < 0.05). The IPE intervention reduced liver fatty accumulation, which improved obesity-related fatty liver disease (P < 0.05). IPE supplementation increased the richness and diversity of the microbial community and altered bacterial population at both the phylum and family level. Intestinal microbial results showed that the relative abundance of Desulfovibrionaceae and Erysipelotrichaceae, which promote the production of inflammatory factors, was reduced. Our results demonstrate that IPE can be used as an effective strategy for delivering propionate to obese mice colon, which can ameliorate obesity and associated metabolic syndrome and modify intestinal microbial homeostasis.
中文翻译：
菊粉中的丙酸菊酯对饮食诱导型肥胖小鼠肥胖相关代谢综合征和肠道微生物体内稳态的影响。
短链脂肪酸（SCFA）在改善肥胖和高脂饮食诱导的相关代谢综合征中起重要作用。我们使用制备的菊粉丙酸酯（IPE）作为将丙酸酯有针对性地释放到结肠的系统，以阐明IPE在饮食诱导的肥胖小鼠中调节肥胖和代谢综合征以及肠道微生物稳态的作用。通过这种策略，IPE显着增加了结肠中SCFA的含量，并导致体重显着降低，胰岛素抵抗的改善以及胃肠激素（胰高血糖素样肽和YY肽）的分泌（P <0.05）。IPE干预减少了肝脏脂肪积累，从而改善了与肥胖相关的脂肪肝疾病（P<0.05）。IPE的补充增加了微生物群落的丰富性和多样性，并改变了门和科的细菌种群。肠道微生物结果表明，促进炎性因子产生的脱硫弧菌科和丹参科的相对丰度降低了。我们的结果表明，IPE可以用作将丙酸酯传递给肥胖小鼠结肠的有效策略，从而可以改善肥胖症和相关的代谢综合征，并改善肠道微生物的体内稳态。
更新日期：2020-05-28
中文翻译：
菊粉中的丙酸菊酯对饮食诱导型肥胖小鼠肥胖相关代谢综合征和肠道微生物体内稳态的影响。
短链脂肪酸（SCFA）在改善肥胖和高脂饮食诱导的相关代谢综合征中起重要作用。我们使用制备的菊粉丙酸酯（IPE）作为将丙酸酯有针对性地释放到结肠的系统，以阐明IPE在饮食诱导的肥胖小鼠中调节肥胖和代谢综合征以及肠道微生物稳态的作用。通过这种策略，IPE显着增加了结肠中SCFA的含量，并导致体重显着降低，胰岛素抵抗的改善以及胃肠激素（胰高血糖素样肽和YY肽）的分泌（P <0.05）。IPE干预减少了肝脏脂肪积累，从而改善了与肥胖相关的脂肪肝疾病（P<0.05）。IPE的补充增加了微生物群落的丰富性和多样性，并改变了门和科的细菌种群。肠道微生物结果表明，促进炎性因子产生的脱硫弧菌科和丹参科的相对丰度降低了。我们的结果表明，IPE可以用作将丙酸酯传递给肥胖小鼠结肠的有效策略，从而可以改善肥胖症和相关的代谢综合征，并改善肠道微生物的体内稳态。
京公网安备 11010802027423号