Biomimetic Gelatin Methacrylate/Nano Fish Bone Hybrid Hydrogel for Bone Regeneration via Osteoimmunomodulation,ACS Biomaterials Science & Engineering

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Biomimetic Gelatin Methacrylate/Nano Fish Bone Hybrid Hydrogel for Bone Regeneration via Osteoimmunomodulation
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-05-17 , DOI: 10.1021/acsbiomaterials.0c00443
Liping Huang ₁ , Jianhua Zhang ₁ , Junfei Hu ₂ , Tianbao Zhao ₁ , Zhipeng Gu ₂

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The consideration of osteoimmunomodulatory activity is crucial to determine the in vivo fate of the bone biomaterials. Herein, we proposed a biomimetic gelatin methacrylate/nano fish bone hybrid hydrogel to systematically investigate its potential for bone regeneration. The results showed that nano fish bone incorporation could not only enhance the mechanical performance of hybrid hydrogel but also modulate the immune microenvironment to further promote bone regeneration. This nano fish bone-based hybrid hydrogel would provide a promising option for developing advanced bone biomaterials with osteoimmunomodulatory activities.

中文翻译：

仿生明胶甲基丙烯酸甲酯/纳米鱼骨混合水凝胶用于通过骨免疫调节进行骨再生。

骨免疫调节活性的考虑对于确定骨生物材料的体内命运至关重要。在这里，我们提出了一种仿生明胶甲基丙烯酸酯/纳米鱼骨混合水凝胶，以系统地研究其骨再生的潜力。结果表明，纳米鱼骨掺入不仅可以增强杂化水凝胶的力学性能，而且可以调节免疫微环境，进一步促进骨再生。这种基于纳米鱼骨的混合水凝胶将为开发具有骨免疫调节活性的高级骨生物材料提供有希望的选择。

更新日期：2020-05-17

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