A convenient and efficient synthesis of L-3,4,5-trioxygenated phenylalanine derivatives from l-tyrosine was developed. Dibromo phenylalanine is converted easily to bis-phenol via copper-catalyzed hydroxylation. The synthetic potential of this methodology has been demonstrated by efficient synthesis of L-3,4,5-trimethoxyphenylalanine methyl ester and one key intermediate of Trabectedin.

中文翻译：

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从L-酪氨酸方便地获得L-3,4,5-三加氧苯丙氨酸化合物

开发了一种由1-酪氨酸方便有效地合成L-3,4,5-三加氧苯丙氨酸衍生物的方法。通过铜催化的羟基化，二溴苯丙氨酸很容易转化为双酚。该方法的合成潜力已通过有效合成L-3,4,5-三甲氧基苯基丙氨酸甲酯和Trabectedin的一种关键中间体得到了证明。