Title: Preparation of reusable copper-based biomass-carbon aerogel catalysts and their application in highly selective reduction of maleimides to succinimides with hydrosilane as a hydrogen source
Authors: Shaohuan Lv(#), Zhanhong Yuan(#), Juanjuan Zheng, Zirong Liu, Jiawang Ye, Jiefang Li, Shanshan Xu, Feng Xie, Dongdong Ye*,Bin Li*
Abstract: Selective reduction is one of organic synthesis's most essential and frequently used transformations. In this work, we developed a novel copper-based biomass-carbon aerogel catalyst (Cu(OTf)2@CAC) as a highly efficient and selective catalyst for maleimide reduction with hydrosilane as a hydrogen source for the first time. A strategy integrating chitin dissolution, nanofibrous regeneration, aerogel construction, and customizable carbonization was designed for the reduction of copper trifluoromethane sulfonate (Cu(OTf)2) to Cu(0) and Cu(I) on the CAC. The Cu(OTf)2@CAC exhibited excellent catalytic activity, chemo-selectivity, and recyclability for selective maleimide reduction to succinimides under mild conditions. Moreover, the Cu(OTf)2@CAC can be reused six times without noticeably losing activity. This work provides a representative and referential approach to achieve efficient catalytic conversion based on the reprocessing and customizable treatment of waste biomass resources.
选择性还原是有机合成中最重要和最常用的转化之一。 在这项工作中，我们开发了一种新型铜基生物质碳气凝胶催化剂（Cu(OTf)2@CAC），作为一种高效、选择性的催化剂，首次以氢硅烷作为氢源用于马来酰亚胺还原。 通过设计了一种集成甲壳素溶解、纳米化再生、气凝胶构建和可定制碳化于一体的制备流程，我们用于将气凝胶上的三氟甲磺酸铜 (Cu(OTf)2) 还原为 Cu(0) 和 Cu(I)。 Cu(OTf)2@CAC在温和条件下选择性马来酰亚胺还原为琥珀酰亚胺表现出优异的催化活性、化学选择性和可回收性。 此外，Cu(OTf)2@CAC可以重复使用六次而不会明显失去活性。 该工作为基于废弃生物质资源的再加工和可定制处理实现高效催化转化提供了具有代表性和参考性的方法。
