博士，副研究员，广州市珠江科技新星、广州中医药大学优秀青年基金获得者、广东省中医院朝阳人才。主要研究方向为液质联用技术在中药复杂体系中的应用。

近期论文

1.        Jing Zhang, Xiaofang Wu, Jiaqi Qiu, Liang Zhang, Liang Zhang, Yating Zhang, Xiaohui Qiu, Zhihai Huang*, and Wen Xu*. Comprehensive Comparison on the Chemical Profile of Guang Chen Pi at Different Ripeness Stages Using Untargeted and Pseudotargeted Metabolomics. J. Agric. Food Chem. 2020, 68, 31, 8483–8495.

2.        Peng Wang, Jing Zhang, Yating Zhang, He Su, Xiaohui Qiu, Lu Gong, Juan Huang, Junqi Bai, Zhihai Huang*, Wen Xu*. Chemical and genetic discrimination of commercial Guangchenpi (Citrus reticulata ‘Chachi’) by using UPLC-QTOF-MS/MS based metabolomics and DNA barcoding approaches. RSC Adv., 2019, 9, 23373DOI: 10.1039/c9ra03740c

3.        Zhang X, Li J, Xie B, Wu B, Lei S, Yao Y, He M, Ouyang H*, Feng Y*, Xu W*, Yang S. Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Mucilage-Induced Rat Model Using Liquid Chromatography Tandem Mass Spectrometry. Front. Pharmacol. 9:282.

4.        XY Zhang, MZ He, SX Lei, B Wu, T Tan, H Ouyang*, W Xu*, YL Feng*. An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandemmass spectrometry based on a rat plasma metabolomics strategy. Journal of Pharmaceutical and Biomedical Analysis.2018, 156: 221–231. 

5.        Zhang J#, Xu W#, Wang P, Huang J, Bai J, Huang Z, Liu X, Qiu X. 2018. Chemical Analysis and Multi-Component Determination in Chinese Medicine Preparation Bupi Yishen Formula Using Ultra-High Performance Liquid Chromatography With Linear Ion Trap-Orbitrap Mass Spectrometry and Triple-Quadrupole Tandem Mass Spectrometry. Front. Pharmacol. 9:568. 

6.        Jing Zhang, Tenghua Wang, Zhiyao Ren, Lu Gong, Juan Huang, Junqi Bai, Xiaohui Qiu*, Wen Xu*. Application of HPLC-LTQ Orbitrap MS for metabolic profiles of Polygonum multiflora extract in rats. Biomedical Chromatography. 2018;32:e4067.

7.        TH Wang, J Zhang, XH Qiu, JQ Bai, YH Gao* , Wen Xu*. Application of Ultra-High-Performance Liquid Chromatography Coupled with LTQ-Orbitrap Mass Spectrometry for the Qualitative and Quantitative Analysis of Polygonum multiflorum Thumb. and Its Processed Products. Molecules 2016, 21, 40. 

8.         Wen Xu, Jing Zhang, Dayuan Zhu, Juan Huang, Zhihai Huang, Junqi Bai, Xiaohui Qiu. Rapid separation and characterization of diterpenoid alkaloids in processed roots of Aconitum carmichaeli using ultra high performance liquid chromatography coupled with hybrid linear ion trap-Orbitrap tandem mass spectrometry. J. Sep. Sci. 2014, 37, 2864–2873 

9.         Xiaohui Qiu, Jing Zhang, Zhihai Huang, Dayuan Zhu, Wen Xu*. Profiling of phenolic constituents in Polygonum multiflorum Thunb. by combination of ultra-high-pressure liquid chromatography with linear ion trap-Orbitrap mass spectrometry. 2013, Journal of Chromatography A, 1292: 121-131  DOI: 10.1016/J.CHROMA.2012.11.051 

10.      Wen Xu, Hui wang, Guang-Xiong Zhou, Xinsheng Yao. Two new 8-O-4′ type lignans from the stem of Schima superba and their cell growth inhibitory activities against human cancer cell lines[J]. Journal of Asian Natural Products Research, 2010, 12(10): 874-878. 

11.      Wen Xu, Jingzhang, Huang Zhihai, Xiaohui Qiu. Identification of new diantrone glycosides from Polygonum multiflorum Thunb. using high-performance liquid chromatography coupled with LTQ-Orbitrap mass spectrometry detection: A strategy for rapid detection of new low abundant metabolites from traditional Chinese medicines. [J]. Analytical Methods, 2012 (4): 1806 

12.    Jing Zhang, Zhi Hai Huang, Xiao Hui Qiu, Yi Ming Yang, Da Yuan Zhu, Wen Xu^*. Neutral Fragment Filtering for Rapid Identification of New Diester -Diterpenoid Alkaloids in Roots of Aconitum carmichaeli by Ultra-High-Pressure Liquid Chromatography Coupled with Linear Ion Trap-Orbitrap Mass Spectrometry [J]. PLOS ONE, 12 (7): e52352. 

13.    Huang J, Zhang Jp, Bai Jq, Wei Mj, Zhang J, Huang Zh, Qu Gh , Xu W*, Qiu Xh*. Chemical profiles and metabolite study of raw and processed Polygoni Multiflori Radix in rats by UPLC-LTQ-Orbitrap MSn spectrometry. Chin J Nat Med, 2018, 16(5): 375-400. 

14.    He Su, Yang Chu, Junqi Bai, Lu Gong, Juan Huang, Wen Xu, Jing Zhang, Xiaohui Qiu, Jiang Xu*, Zhihai Huang*. Genome-Wide Identification and Comparative Analysis for OPT Family Genes in Panax ginseng and Eleven Flowering Plants. Molecules 2019, 24, 15. 

15.    Huang Z, Xu J, Xiao S, Liao B, Gao Y, Zhai C, Qiu X, Xu W, Chen S*. Comparative optical genome analysis of two pangolin species: Manis pentadactyla and Manis javanica. GigaScience, 5, 2016, 1–5. 

16.    L Gong, X Qiu, J Huang, W Xu, J Bai, J Zhang, H Su, C Xu, Z Huang*. Constructing a DNA barcode reference library for southern herbs in China: A resource for authentication of southern Chinese medicine. PLoS ONE 13(7): e0201240. 

17.     JY Qi, J Yu, YF Tan, RS Chen, W Xu, YF Chen, J Lu, Q Liu, JS Wu, WW Gu, MZ Zhang1* Mechanisms of Chinese Medicine Xinmailong’s protection against heart failure in pressure-overloaded mice and cultured cardiomyocytes. Sci. Rep. 2017, 7, 42843. 

18.     Jing Zhang, Wen Xu, Dinghong Wu, Dayuan Zhu, Chuanjian Lu, Xiaohui Qiu. Effects of extracting methods on the chemical component changes of Radix astragali and Radix notoginseng after compatibility [J]. Medicinal Plants, 2013, 4 (1): 1-4.