To address the challenges of high carrier recombination rate, narrow light response range and instability of the metal sulfides photocatalyst, ZnIn₂S₄ nanosheet is modified by Ni-S bonds and S vacancies (S_V) through a solvothermal and light assisted impregnation methods. It should be noted that the S of Ni-S bonds is offered by the ZnIn₂S₄ nanosheet. In addition, the S_V are generated on the surface of the ZnIn₂S₄ nanosheet through the induction of Ni-S bonds. Furthermore, compared with the initial ZnIn₂S₄ nanosheet, the modified ZnIn₂S₄ nanosheet exhibits more superior property of photocatalytic H₂ production. Under visible light or simulated sunlight irradiation, the H₂ production rate of the modified ZnIn₂S₄ nanosheet is 1486 and 6071 μmol·g^-1·h^-1, and it is almost 3.9 and 4.4 times higher than that of the initial ZnIn₂S₄ nanosheet. In addition, combined with the analyses of microstructure characterizations, photoelectric properties, theoretical calculations and in situ XPS, the superior property of the modified ZnIn₂S₄ nanosheet is attributed to the synergistic effects of the Ni-S bonds and S_V. Because the Ni-S bonds and S_V can significantly enhance the separation efficiency of the photoproduced electron-holes and offer abundant active sites for H₂ production. This study offers an innovative perspective for optimizing the metal sulfides to improve their photocatalytic H₂ evolution property.