Recent work by Didar Baimanov et al. has been published in Nanoscale Horizons itled with Stereoselective coronas regulate the fate of chiral gold nanoparticles in vivo.(Nanoscale Horizons, 10.1039/d3nh00124e）

Our findings support a new concept that surface chirality plays a crucial role in the biodistribution and cellular uptake of chiral nanoparticles via stereoselective formation of the protein corona. In this work, we foundthat the chirality property can be transferred from nanoparticles’surfaceligands to the adsorbed proteins, i.e., the protein corona. Chiralityspecific protein coronas were observed in complement and acute phaseroteins, whereas lipoproteins on chiral nanoparticles exhibited altered functionality, acting as dysopsonin or opsonin. On the surface of chiral gold nanoparticles, lipoproteins could enhance or reduce LDL receptormediated macrophage uptake. This study revealed the role of chirality in mediating protein corona formation and its effect on the blood clearance and biodistribution. Overall, this study demonstrated that the stereoselective coronas regulate the behavior and fate of chiral gold nanoparticles in vivo. We highlight the importance of surface chirality in the development of targeted nanomedicine and open a new avenue for the design of more efficient and effective nanomedicines.