In collaboration with Professor Martin Oestreich's research group at the Technical University of Berlin, we elucidated the mechanistic aspects of boron Lewis acid-catalyzed ring contraction and skeletal rearrangement of acyclic amines, with findings published in Angewandte Chemie International Edition. - 课题组新闻

当前位置：首页 > 课题组新闻 > In collaboration with Professor Martin Oestreich's research group at the Technical University of Berlin, we elucidated the mechanistic aspects of boron Lewis acid-catalyzed ring contraction and skeletal rearrangement of acyclic amines, with findings published in Angewandte Chemie International Edition.

In collaboration with Professor Martin Oestreich's research group at the Technical University of Berlin, we elucidated the mechanistic aspects of boron Lewis acid-catalyzed ring contraction and skeletal rearrangement of acyclic amines, with findings published in Angewandte Chemie International Edition.

发布时间：2024-09-25

Publication Link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202410483

Key Research Highlights:

Establishment of fundamental principles governing silylium ion-mediated rearrangement reactions
Demonstration of selective heterocyclic scaffold construction utilizing analogous catalytic conditions and reaction precursors
Development of a methodology enabling expeditious structural interconversion among diverse amine derivatives, presenting significant implications for drug discovery applications