张会芳，2013年本科毕业于河南农业大学，2019年博士毕业于华东师范大学，2019年到2023年9月在华东师范大学进行博士后训练。2023年10月起在复旦大学附属肿瘤医院任职唐爽教授助理研究员。博士与博后期间从事表观遗传方向相关研究，主攻方向：DNA甲基化修饰调控、蛋白翻译后修饰调控以及组蛋白翻译后修饰调控。目前的研究方向是表观遗传对肿瘤适应性的调控与机制研究探究。
Grant
中国自然科学基金青年项目，2025.1.1-2027.12.31。30万元，主持。
中国博士后科研基金项目，11300-41211C-20009, 哺乳动物感知甲基供体SAM变化稳定维持DNA甲基化状态的机制与功能研究，2020.07.01至2022.06.30，8万元，主持。
Publication
1. Huifang Zhang#, Qinqin Gao#, Shuo Tan, Jia You, Cong Lyu, Yunpeng Zhang, Mengmeng Han, Zhaosu Chen, Jialun Li, Hailin Wang, Lujian Liao, Jun Qin, Jiwen Li* and Jiemin Wong*. SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1. Nucleic Acids Research. 2019,47:9053-9068.
2. Li Kang#, Huifang Zhang#, Yaling Wang#, Manyu Chu, Jianzhong He, Mengyang Xue, Liu Pan, Zhen Wang, Zhaosu Chen, Yuanyong Huang, Zitai Chen, Enmin Li, Jiwen Li, Liyan Xu, Rong Zhang*, and Jiemin Wong*.Control of SOX2 Protein Stability and Tumorigenic Activity in Esophageal Cancer Cells by Cochaperone E3 Ligase CHIP. Oncogene,2023.
3. Peilu She, Huifang Zhang, Xiangwen Peng, Jianjian Sun, Bangjun Gao, Yating Zhou, Xuejiao Zhu, Xueli Hu, Kaa Seng Lai, Jiemin Wong, Bin Zhou, Linhui Wang*, Tao P. Zhong*. The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase. Development, 2020,147.
4. Zhen Wang#, Li Kang#, Huifang Zhang, Yuanyong Huang, Lan Fang, Menghan Li, Peter J. Brown, Cheryl H. Arrowsmith, Jiwen Li* and Jiemin Wong*. AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation. Oncogene, 2019, 8:5250-5264.
5. Wei Wei#, Xiaoguang Liu#,Jiwei Chen#, Shennan Gao, Lu Lu, Huifang Zhang, Guangjin Ding, Zhiqiang Wang, Zhongzhou Chen, Tieliu Shi, Jiwen Li,Jianjun Yu*, Jiemin Wong*. Class I histone deacetylases are major histonedecrotonylases: evidence for criticaland broad function of histonecrotonylation in transcription. Cell Research.2017, 27(7):898-915.
6. Zhaosu Chen#, Yunpeng Zhang#, Qingqing Guan, Huifang Zhang, Jing Luo, Jialun Li,Wei Wei, Xiang Xu, Lujian Liao, Jiemin Wong* and Jiwen Li*. Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation by direct binding of Histones. Journal of Biological Chemistry.2021,297(4).
