研究兴趣：酶的结构解析与酶催化机制的计算分析

文章发表：

1.  Z.W. Deng, H. Su, X.D. Hou, H.B. Xu, Z.B. Yuan, X. Sheng*, Y.J. Rao*,  Mechanistic Investigation on C–C Bond Cleavage of Anthraquinone Catalyzed by an Atypical Non-heme Iron-dependent Dioxygenase BTG13, ACS Catal, accepted.

2. D. Li^#, Z.W. Deng^#, X.D. Hou, Z.J. Qin, X.L. Wang, D.J. Yin, Y. Chen, Y.J. Rao, J. Chen, J.W. Zhou*, Structural Insight into the Catalytic Mechanisms of an L‐Sorbosone Dehydrogenase, Advanced Science, 2023,10(30):e2301955

3. C.T. Zhu, Z.B. Yuan*, Z.W. Deng, D.J. Yin, Y. Zhang, J.W. Zhou*, Y.J. Rao*, Photoenzymatic Enantioselective Synthesis of Oxygen-Containing Benzo-Fused Heterocycles, Angew, 2023, e202311762.

4. X.Z. Liu, Z.B. Yuan, H. Su, X.D. Hou, Z.W. Deng, H.B. Xu, B.D. Guo, D.J. Yin, X. Sheng, Y.J. Rao*, Molecular Basis of the Unusual Seven-membered Methylenedioxy Bridge Formation Catalyzed by Fe(II)/α-KG-dependent Oxygenase CTB9, ACS Catal, 2022, 12 (6), 3689-3699.

5. X.D. Hou#, H.B. Xu#, Z.W. Deng, Y.J. Yan, Z.B. Yuan, X.Z. Liu, Z.P. Su, S. Yang, Y. Zhang, Y.J. Rao*, Discovery of the Biosynthetic Pathway of Beticolin 1 Reveals a Novel Non-heme Iron-dependent Oxygenase for Anthraquinone Ring Cleavage, Angew, 2022, online.

6. X.D. Hou#, H.B. Xu# Z.B. Yuan, Z.W. Deng, K. Fu, Y. Gao, C.M. Liu, Y. Zhang, Y.J. Rao*, Structural analysis of an anthrol reductase inspires enantioselective synthesis of enantiopure hydroxycycloketones and β-halohydrins, Nature Communications, Accepted, 2023.

7. S. Yang, X.D. Hou, Z.W. Deng, L.F. Yang, Q. Ping, Z.B. Yuan, Y. Zhang, Y.J. Rao*, Improving the Thermostability of Glycosyltransferase YojK by Targeting Mutagenesis for Highly Efficient Biosynthesis of Rebaudioside D, Molecular Catalysis, 2023, online.

8. B.D. Guo, X.D. Hou, Y. Zhang, Z.W. Deng, Q. Ping, K. Fu, Z.B. Yuan, Y.J. Rao*, Highly Efficient Production of Rebaudioside D Enabled by Structure-guided Engineering of Bacterial Glycosyltransferase YojK,Front Bioeng Biotechnol, 2022, accepted.

9. B.D. Guo, Z.W. Deng, F. Meng, Q.F. Wang, Y. Zhang, Z.B. Yuan, Y.J. Rao*, Enhancement of Rebaudioside M Production by Structure-guided Engineering of Glycosyltransferase UGT76G1, J Agric Food Chem，Accepted, 2022

10. H. Huang, X.D. Hou, R.R. Xu, Z.W. Deng, Y. Wang, G.C. Du, Y.J. Rao*, J. Chen, Z. Kang, Structure and cleavage pattern of a hyaluronate 3-glycanohydrolase in the glycoside hydrolase 79 family, Carbohyd Polym, 277 (2022).