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孙秀云 博士后     进组时间: 2011.09

2016.7-2019.10 清华大学药学院,博士后

2011.9-2016.7 清华大学药学院,博士

2007.9-2011.7 山东大学药学院,本科


研究方向:药物化学、化学生物学


个人邮箱:sunxiuyun622@126.com


已发表论文:

1.  Sun, X. ‡, Wang, J. ‡, Yao, X. ‡, Zheng, W., Mao, Y. Lan, T., Wang, L., Sun, Y., Zhang, X., Zhao, Q., Zhao, J., Xiao, R.-P., Zhang, X., Ji, G., Rao, Y. “A chemical approach for global protein knockdown from mice to non-human primates.” Cell Discovery 2019, 5

2.  Xia Yao‡, Xiuyun Sun‡, Shuyu Jin, Ling Yang, Hongjiang Xu, Yu Rao. “Discovery of 4-Aminoquinoline-3-carboxamide Derivatives as Potent Reversible Bruton’s Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis”. J. Med. Chem. 2019, 62, 6561-6574

3.  Zong, Y. ‡, Sun, X. ‡, Gao, H., Meyer, K.J., Lewis, K., Rao, Y. “Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and Teixobactin”. Journal of Medicinal Chemistry 2018, 61, 3409-3421.

4.  X. Sun‡, Y. Sun‡, Y. Rao*, “Cyclobutanones as Useful Synthons for the Preparation of Bioactive Molecules and Fused-Ring Chemicals”. Curr. Org. Chem., 2016, 20, 1878-1901.

5.  X. Sun‡, X. Yao‡, C. Zhang, and Yu Rao.*, “Palladium (II) catalyzed ortho C-H iodination of phenylcarbamates at room temperature using cyclic hypervalent iodine reagents”. Chem. Commun., 2015, 51, 10014-10017.

6.  X. Sun, Y. Sun, Y. Rao.*, “A gram-scale synthesis of multi-substituted arenes via palladium catalyzed C-H activation”. Chinese Chem. Lett., 2014, 25, 667-669.

7.  X. Sun‡, Y. Sun‡, C. Zhang, and Yu Rao.*, “Room-Temperature Palladium-Catalyzed C-H Chlorination by Weak Coordination: One-Pot Synthesis of 2-Chlorophenols with Excellent Regioselectivity”. Chem. Commun., 2014, 50, 1262-1264.

8.  X. Sun‡, G. Shan‡, Y. Sun, and Y. Rao.*, “A General Approach for Regio- and Chemoselective C-H Chlorination/Bromination of Electron-Deficient Arenes via Weak Coordination and A Preliminary Study of Priority Order of Relative Directing Group Ability”. Angew. Chem. Int. Ed. 2013, 52, 4440-4444.