We herein present an approach of photo-induced disproportionation for preparation of Type-I photodynamic agents. As a proof of concept, BODIPY-based photosensitizers were rationally designed and prepared. The photo-induced intermolecular electron transfer between homotypic chromophores leads to the disproportionation reaction, resulting in the formation of charged intermediates, cationic and anionic radicals. The cationic radicals efficiently oxidize the cellar important coenzyme, tetrahydrobiopterin (BH4), and the anionic radicals transfer electrons to oxygen to produce superoxide radicals (O2−•). One of our Type-I photodynamic agents that not only self-assembles in water but also effectively targets the endoplasmic reticulum. It displayed excellent photocytotoxicity even in highly hypoxic environments (2% O2), with a half-maximal inhibitory concentration (IC50) of 0.96 μM, and demonstrated outstanding antitumor efficacy in murine models bearing HeLa tumors.
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恭喜滕坤旭文章被Angew. Chem. Int. Ed. 接收 Congratulations to Kun-Xu Teng for his article accepted by Angew. Chem. Int. Ed.
恭喜滕坤旭文章被Angew. Chem. Int. Ed. 接收 Congratulations to Kun-Xu Teng for his article accepted by Angew. Chem. Int. Ed.
发布时间：2024-01-23