教育经历:
2005.09-2009.06,华中科技大学,同济医学院药学院,学士
2009.09-2012.06,清华大学,医学院,生物学,硕士
2012.09-2016.10,清华大学,生命科学学院,博士,导师:钱锋
2016.10-2019.01,清华大学,药学院,博士后,合作导师:钱锋
2019.01-至今,中央民族大学,药学院,讲师
研究方向:物理药剂学,难溶性药物的递送
个人邮箱:yueya520@126.com
代表性成果:
1. Yuejie Chen, Yipshu Pui, Huijun Chen, Shan Wang, Peter Serno, Wouter Tonnis, Linc Chen, Feng Qian. Polymer-Mediated Drug Supersaturation
Controlled by Drug-Polymer Interactions Persisting in an Aqueous Environment. Molecular Pharmaceutics, 2019, 16(1), pp 205-213
2. Yipshu Pui, Yuejie Chen, Huijun Chen, Shan Wang, Chengyu Liu, Wouter Tonnis, Linc Chen, Peter Serno, Stefan Bracht, Feng Qian. Maintaining Supersaturation of Nimodipine by PVP with or without the Presence of Sodium Lauryl Sulfate and Sodium Taurocholate. Molecular Pharmaceutics, 2018, 15(7), pp 2754-2763
3. Shan Wang, Chengyu Liu, Yuejie Chen, Zhen Zhang, Alan Zhu, Feng Qian. A high-sensitivity HPLC-ELSD method for HPMC-AS quantification and its application in elucidating the release mechanism of HPMC-AS based amorphous solid dispersions. European Journal of Pharmaceutical Sciences, 2018, 122(15), pp 303-310
4. Shan Wang, Chengyu Liu, Yuejie Chen, Alan (Donghua) Zhu, Feng Qian. Aggregation of Hydroxypropyl Methylcellulose Acetate Succinate under Its Dissolving pH and the Impact on Drug Supersaturation. Molecular Pharmaceutics. 2018, 15(10), pp 4643-4653
5. Chengyu Liu, Zhengsheng Liu, Yuejie Chen, Zhen Chen, Huijun Chen, Yipshu Pui, Feng Qian. Oral bioavailability enhancement of β-lapachone, a poorly soluble fast crystallizer, by cocrystal, amorphous solid dispersion, and crystalline solid dispersion, European Journal of Pharmaceutics and Biopharmaceutics, 2018, 124, pp 73-81
6. Yuejie Chen, Shujing Wang, Shan Wang, Chengyu Liu, Ching Su, Michael Hageman, Munir Hussain, Roy Haskell, Kevin Stefanski, Feng Qian. Initial Drug Dissolution from Amorphous Solid Dispersions Controlled by Polymer Dissolution and Drug-Polymer Interaction. Pharmaceutical Research. 2016, 33(10), pp 2445-2458
7. Yuejie Chen, Shujing Wang, Shan Wang, Chengyu Liu, Ching Su, Michael Hageman, Munir Hussain, Roy Haskell, Kevin Stefanski, Feng Qian. Sodium Lauryl Sulfate Competitively Interacts with HPMC-AS and Consequently Reduces Oral Bioavailability of Posaconazole/HPMCAS Amorphous Solid Dispersion. Molecular Pharmaceutics. 2016, 13(8), pp 2787-2795
8. Chengyu Liu, Zhen Chen, Yuejie Chen, Shujing Wang, Guoqiang Liu, Feng Qian. Improving Oral Bioavailability of Sorafenib by Optimizing the “Spring” and “Parachute” Based on Molecular Interaction Mechanisms. Molecular Pharmaceutics. 2016, 13(2), pp 599-608
9. Yuejie Chen, Chengyu Liu, Zhen Chen, Ching Su, Michael Hageman, Munir Hussain, Roy Haskell, Kevin Stefanski, Feng Qian. Drug-Polymer-Water Interaction and Its Implication for the Dissolution Performance of Amorphous Solid Dispersions. Molecular Pharmaceutics. 2015, 12(2), pp 576-589
10. Yue-Jie Chen, Rui-Yang Bao, Xiao-Dong Zhang, Ye-Feng Tang. Formal synthesis of (+)-tashiromine and study toward the total synthesis of (+)-stemoamide. Chinese Chemical Letters. 2013, 24(11), pp 953-956
11. Weiwu Ren, Yichao Bian, Ziyang Zhang, Hai Shang, Pengtao Zhang, Yuejie Chen, Zhen Yang,Tuoping Luo, Yefeng Tang. Enantioselective and Collective Syntheses of Xanthanolides Involving a Controllable Dyotropic Rearrangement of cis-β-Lactones. Angew. Chem. Int. Ed. Engl. 2012, 51, pp 6984-6988
12. Ruiqing Lian, Yuejie Chen, Zenglu Xu, Xiaodong Zhang. Soluble transforming growth factor-β1 receptor II might inhibit transforming growth factor-β-induced myofibroblast differentiation and improve ischemic cardiac function after myocardial infarction in rats. Coronary Artery Disease. 2010, 21(6), pp 369-377