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田周 博士生     进组时间: 2021.09

2008-2012  黄河科技学院       学士

2012-2015  南京中医药大学    硕士

2016-2021  清华大学              研究助理

2021-至今   清华大学              博士在读

 

研究方向:蛋白质物理、高浓度蛋白制剂溶液行为(稳定性和黏度)的研究;

 

代表性研究论文:                                                                      

1)      Tian, Z, Jiang X., Chen Z., Huang C, Qian F.; Quantifying protein shape to elucidate its influence on solution viscosity in high-Concentration electrolyte solutions. Molecular Pharmaceutics. 2024.

2)      Tian, Z, Qian F.; Adenosine triphosphate-induced rapid liquid liquid phase separation of a model IgG1 mAb. Molecular Pharmaceutics. 2021,18(1):267-274.

3)      Tian, Z, Xu L., Zhang N., Qian F.; First order nucleation and subsequent growth promote liquid-liquid phase separation of a model IgG1 mAb. International Journal of Pharmaceutics, 2020. 119681,

4)      Tian, Z., Li, B., Guo, L., Wu, M., Fu, T., Cheng, H., Zhu, H.; Purification and biochemical characterization of a novel fibrinolytic enzyme, PSLTro01, from a medicinal animal Porcellio scaber Latreille. International Journal of Biological Macromolecules, 2015, 80, 536-546.

5)      Wu G, Wang S, Tian Z, Zhang N, Sheng H, Dai W, Qian F., Elucidating the weak protein-protein interaction mechanisms behind the liquid-liquid phase separation of a mAb solution by different types of additives, European Journal of Pharmaceutics and Biopharmaceutics, 2017, 120: 1-8.

6)      Wang S, Zhang X, Wu G, Tian Z, Qian F.; Optimization of high-concentration endostatin formulation: Harmonization of excipients' contributions on colloidal and conformational stabilities, International Journal of Pharmaceutics, 2017, 530(1-2): 173-186.

7)      Wang, S., Wu, G., Zhang, X., Tian, Z., Zhang, N., Hu, T., Dai.; W., Qian F, Stabilizing two IgG1 monoclonal antibodies by surfactants: Balance between aggregation prevention and structure perturbation, European Journal of Pharmaceutics and Biopharmaceutics, 2017, 114: 263-277.

8)   田周,高浓度抗体制剂:液-液相分离和高黏度行为的探究和思考,2023年生物药质量全国巡回沙龙之生物药制剂开发,北京,2023-06-08会议报告

9)田周,基于湿法超细微粉碎提取与膜耦合的中药动物药活性物质分离纯化的探索,2022年第七届全国医药行业膜分离技术应用研讨会,江苏南京, 2022-07-22至2022-07-24(会议报告)

 

邮箱:tz21@mails.tsinghua.edu.cn