仇萌教授在Advanced Science期刊上发表题为“Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for 

Effective Treatment of Cancer”（https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202001191）的文章，文章摘要如下：

Abstract：

Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, 

ineffective tissue penetration, chemotherapy/hyperthermia‐induced inflammation, and tumor angiogenesis. A versatile nanomedicine 

offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a 

promising biophotonic nanoplatform is developed based on the zirconium carbide (ZrC) nanosheet as a deep PTT‐photosensitizer and on‐

demand designed anticancer prodrug SN38‐Nif, which is released and activated by photothermia and tumor‐overexpressed esterase. In 

vitro and in vivo experimental evidence shows the potent anticancer effects of the integrated ZrC@prodrug biophotonic nanoplatform by 

specifically targeting malignant cells, chemotherapy/hyperthermia‐induced tumor inflammation, and angiogenesis. In mouse models, the 

ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation and angiogenesis. The findings unravel a promising 

biophotonic strategy for precision treatment of cancer.