付建冶博士在Coordination Chemistry Reviews期刊上发表题为“Janus nanoparticles for cellular delivery chemotherapy: Recent advances
and challenges”(https://doi.org/10.1016/j.ccr.2020.213467)的文章,文章摘要如下:
Abstract
Anisotropic Janus nanoparticles have been widely investigated in recent years on both the nanoparticles preparation strategies and the advanced applications. Janus
nanoparticles possess biphasic geometry of distinct compositions or asymmetric morphologies that bring distinct novel properties. Janus nanoparticles have been
widely used in various applications such as catalysts, nanomotors, and nanomedicine. In biomedical fields, the special spatially separated surface chemistry of Janus
nanoparticles provides efficient targeting and delivery capability, which can be used to design next generation delivery vectors. Moreover, the unique asymmetric
morphology of Janus nano-particles exhibits unusual behaviours when internalized by cells. Janus nanoparticles can be developed as new probes to investigate the
nanoparticlecell interaction during the critical cellular delivery processes. This review focuses on recent progress of the design and synthesis of novel Janus
nanoparticles and their unusual performance in cellular delivery related applications. The advantages and new opportunities of Janus nanoparticles as cellular
delivery vectors are discussed.