Congratulations to Dr Wei Jiang and Prof. Xing Wang, our collaborated work combined with Wuhan University, Zhenzhou Universtiy and Shanxi Medical University, we sucessfully constructed a H2O2 self-producing single-atom nanozyme hydrogels which served as light controlled oxidative stresss amplifier for enhanced synergistic tumor therapy by transforming cold tumors.

This work aims to solve the challenges of nanozyme based tumor cataltyic therapy, which are the the "cold" immune microenvironment and limited amount of H2O2 in solid tumors.  In this nanozyme hydrogel system, the Pd-C SAzyme converts near-infrared laser into heat, resulting in agarose degradation and consequent camptothecin release. The camptothecin increases H2O2 level in tumors by activating nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX), improving the catalytic performance of SAzymes with peroxidase-like activity. Moreover, the combination of photothermal therapy, chemotherapy, and nanozyme-based catalytic therapy further facilitates tumor immunogenic death and enhanced antitumor immunity. Our results reveal the synergistic antitumor potential of the novel SAzyme/chemotherapeutics-based hydrogel system.