李娟，PI，中国科学院杭州医学研究所研究员，博士生导师。国家优秀青年科学基金获得者，省青年拔尖人才，省卫生高层次人才创新人才，现任浙江省功能核酸基础与临床应用重点实验室副主任、浙江省核酸适体工程研究中心副主任。主要从事肿瘤分子诊断与靶向治疗领域的基础应用研究，取得了三方面的研究成果：（1）发展了系列新型变构核酸适体分子探针，实现蛋白及其翻译后修饰的高灵敏分析，为疾病精准诊断提供新工具，部分成果进入临床转化研究。（2）发展了基于硫醇交换作用的核酸跨膜新途径，揭示其直接胞质递送新机制，为发展核酸药物和疫苗提供新方法，其中获得的2项中国发明专利和1项PCT专利成功实现转让，金额达200万元；（3）提出了人工蛋白配对新概念，开发新型二价核酸适体药物，实现靶蛋白功能的有效抑制，为核酸药物设计提供新策略。

近年来，以通讯作者在国际高水平刊物上发表SCI论文60余篇，包括Science、J. Am. Chem. Soc.、 Angew. Chem. Int. Ed.，CCS Chemistry，Chem.Soc. Rev. 等。先后主持国家重点研发计划“合成生物学”专项课题、国家自然科学基金重大研究计划培养项目、优秀青年科学基金、国家自然科学基金面上等项目。获得中国发明专利9项，PCT专利2项。多次在国际学术会议邀请做报告。担任BME Frontiers杂志副主编，美国化学会《Analytical Chemistry》杂志编辑顾问委员会委员、《肿瘤学杂志》中青年编委、《高等学校化学学报》《Chemical Research in Chinese Universities》青年执行编委。作为专刊特邀主编在BME Frontiers组织了“DNA Nanotechnology for Advanced Biomedical Applications”专刊。获中国化学会青年化学奖，省部级自然科学奖一等奖1项（第二完成人）。

10篇代表性论文：

1.      Zhentao Shao, Hui Yuan, Zhilan Zhou, Ya Wang, Peidong Hou, Hexin Nan, Wei Wang, Weihong Tan, and Juan Li*, Visualization of Protein-Specific Glycation in Living Cells via Bioorthogonal Chemical Reporter, Angew. Chem. Int. Ed., 2022, 10.1002/anie.202210069. (IF=16.823)

2.      Da Han, Juan Li*, Weihong Tan*, CRISPR propels a smart hydrogel, Science, 2019, 365(6455), 754-755. (IF=41.037)

3.      Da Zhang, Youshi Zheng, Ziguo Lin, Xiaolong Liu, Juan Li*, Huanghao Yang* and Weihong Tan, Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking for Enhanced Adoptive Immunotherapy in Solid Tumors, Angew. Chem. Int. Ed. 2020, 59, 12022-12028. (IF=16.823)

4.      Kaiming Chen, Jie Zhou, Zhentao Shao, Jia Liu, Jia Song, Ruowen Wang*, Juan Li*, and Weihong Tan*, Aptamer as a Versatile Molecular Tool for Antibody Production Monitoring and Quality Control, J. Am. Chem. Soc., 2020, 142, 12079-12086 (IF=16.383)

5.      Shan Chen, Zhifei Xu, Wen Yang, Xiahui Lin, Jingying Li, Juan Li,* and Huanghao Yang, Logic-Gate-Actuated DNA-Controlled Receptor Assembly for the Programmable Modulation of Cellular Signal Transduction, Angew. Chem. Int. Ed., 2019, 58, 18186-18190. (IF=16.823)

6.      Long Li, Xigao Chen, Cheng Cui, Xiaoshu Pan, Xiaowei Li, Hoda Safari Yazd, Qiong Wu, Liping Qiu, Juan Li*, and Weihong Tan*, Aptamer displacement reaction from live-cell surfaces and its applications, J. Am. Chem. Soc., 2019, 141, 17174-17179. (IF=16.383)

7.      Liping Wang, Hong Liang, Jin Sun, Yichang Liu, Jinyu Li, Jingying Li, Juan Li*, Huanghao Yang*, Bispecific Aptamer Induced Artificial Protein-Pairing: A Strategy for Selective Inhibition of Receptor Function, J. Am. Chem. Soc. 2019, 141, 12673-12681. (IF=16.383)

8.      Jie Zhou, Liqin Sun, Liping Wang, Yichang Liu, Jinyu Li, Jingying Li, Juan Li,* and Huanghao Yang*, Self-Assembled and Size-Controllable Oligonucleotide Nanospheres for Effective Antisense Gene Delivery through an Endocytosis Independent Pathway, Angew. Chem. Int. Ed., 2019, 58, 5236-5240. (IF=16.823)

9.      Jingying Li, Shuya Liu, Liqin Sun, Wei Li, Su-Yun Zhang, Sheng Yang, Juan Li^*, and Huang-Hao Yang^*, Amplified Visualization of Protein-specific Glycosylation in Zebrafish via Proximity-induced Hybridization Chain Reaction, J. Am. Chem. Soc. 2018, 140, 16589-16595. (IF=16.383)

10.       Hong Liang, Shan Chen, Peipei Li, Liping Wang, Jingying Li, Juan Li*, Huang-Hao Yang* and Weihong Tan, Nongenetic approach for imaging protein dimerization by aptamer recognition and proximity-induced DNA assembly, J. Am. Chem. Soc., 2018, 140, 4186-4190. (IF=16.383)