Our paper has been published in Advanced science
发布时间:2023-01-25
1月25日,我团队在Advanced science杂志上发表题为“Engineered microparticles for treatment of murine brain metastasis by reprograming tumor
microenvironment and inhibiting MAPK pathway”的研究成果。团队利用基因工程构建了一种可跨越血脑屏障的放疗衍生微囊泡,并装载去泛素化酶USP7
的抑制剂P5091,实现了对多发性肺癌脑转移的有效治疗,并显著提升了免疫治疗的应答率。