研究方向

早期致力于出生缺陷-神经管畸形发生机制研究。目前致力于代谢失调如何导致发育异常及出生缺陷的研究。从5‘甲基四氢叶酸和果糖小分子入手，寻找和心脏发育相关的相互作用基因，在信号通路中研究小分子是通过什么基因，在哪些信号通路影响心脏发育。

代表论文

1. Yan Shi, Yi Ding, Yun-Ping Lei, Xue-Yan Yang, Guo-Ming Xie,Jun Wen, Chun-Quan Cai, Hong Li, Ying Chen, Ting Zhang, Bai-Lin Wu, Li Jin, Ye-Guang Chen, Hong-Yan Wang. Identification of rare loss-of-function mutations of DACT1 in human neural tube defects. Human Mutation，2012, 33(10):1450-1455.

2. Wu H, Shi Y, Lin Y, Qian W, Yu Y, Huo K. Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1. Mol Cell Biochem. 2011, 357:209-215.

3. Yan Shi, Kan Ye, Huiling Wu, Yixing Sun, Huili Shi, Keke Huo. Human SMAD4 is phosphorylated at Thr9 and Ser138 by interacting with NLK. Mol Cell Biochem，2010, 333(1-2):293-298.

4. Yan Shi, Guanghui Han, Huiling Wu, Kan Ye, Zhipeng Tian, Jiaqi Wang, Huili Shi, Mingliang Ye, Hanfa Zou, Keke Huo. Casein Kinase 2 interacts with human mitogen- and stress-activated protein kinase MSK1 and phosphorylates it at Multiple sites. BMB Rep, 2009, 42:840-845.

5. Xiaoxie Ye, Yan Shi, Keke Huo, Dong Chen. Establish a recombinant yeast detection system to study the effect of MIP on transactivation function of hMafF in US2-driven gene transcription. J Microbiol Meth. 2009, 79:96-100.

6. Li Li, Yan Shi, Huiling Wu, Bingbing Wan, Pu Li, Li Zhou, Huili Shi, Keke Huo. Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. Mol Cell Biochem, 2007, 304:297-304. 

7. Fengrui Zhang, Yujun Di, Jinjun Li,Yan Shi, Liping Zhang, Chunyan Wang, Xianghuo He, Yongzhong Liu, Dafang Wan, Keke Huo, Jianren Gu. Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1. BBA-Gene Struct Expr, 2006, 1759:514-25.