赵健元，男，上海交通大学医学院附属新华医院研究员，博士生导师。国家基金 委优秀青年基金、863 青年科学家专项获得者，上海市优秀学科带头人。2011 年博士毕业于 复旦大学，之后赴美国约翰霍普金斯大学医学院从事博士后工作，2013 年作为人才引进回 复旦大学，先后被聘为副研究员、研究员和博士生导师，任生命科学学院、遗传工程国家重 点实验室 PI，兼任复旦附属中山医院 PI，2019 年入选复旦大学“卓越 2025-卓识杰出人才” 计划。2022 年作为人才引进全职加入上海交通大学医学院附属新华医院，任心血管发育与 再生医学研究所 PI、环境与儿童健康教育部和上海市重点实验室 PI，国家卫生健康委员会 新生儿疾病重点实验室学术委员。
研究方向为营养代谢失调致发育相关疾病的分子机制，在出生缺陷、心血管病、肿瘤等 复杂疾病的发病机制研究中取得系列高水平研究成果。以通讯及第一作者(含共同)发表 SCI 论文 40 篇，篇均影响因子 16.5，其中 20 篇发表于 IF>10 期刊，包括 Circulation(2 篇)、 Eur Heart J、J Hepatol、Nat Commun(5 篇)、STTT(3 篇)等，被引 2100 余次，获同行高 度评价，数十次被 Cell、Circulation、Nature Review Neuroscience、Nature Neuroscience 等杂 志评述和报道。近五年获批十余项省部级项目，主持 863 青年科学家专项及多项基金委项 目，获基金委创新群体、国家重大研究计划和重点研发计划资助(骨干)；作为主要完成人 获教育部自然科学一等奖和国家妇幼健康科学技术一等奖。
研究方向
营养代谢调控发育
受教育经历
2008.09-2011.07：复旦大学，生命科学学院，遗传学，博士（导师：王红艳、金力）
2003.09-2006.07：安徽大学，生命科学学院，生化分子生物学，硕士（导师：李进华)）
1999.09-2003.07：安徽大学，生命科学学院，生物技术，本科
工作经历
2022.03- 至今：上海交通大学医学院附属新华医院，心血管发育与再生医学研究所PI、环境与儿童健康教育部和上海市重点实验室 PI
2013.09-2022.02：复旦大学生命科学学院(引进人才)，研究员、博导;复旦大学附属中山医院，双聘教授
2011.11-2013.08：美国 The Johns Hopkins University，博士后(导师:陶元祥)
2006.10-2007.01：美国 Fred Hutchinson Cancer Research Center，访问学者(导师:Linial Maxine)
2006.07-2008.09：安徽省体育局，助理研究员
代表论文
（*第一作者，#通讯作者）
1. Zhao R*, … Zhou XY#, Cao J#, Sun K#, Zhao JY#. Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease. Cell Reports Medicine 2023; 4(3):100953. (IF: 16.99)
2. Zhao R*, … Tao H#, Zhao SM#, Zhao JY#. Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response. Cell Reports 2023; 42(4):112400. (IF: 9.99)
3. Tang L*, … Zhao JY#, Jin L#. Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage. Cell Reports Medicine 2023; doi:10.1016/j.xcrm.2023.101026. (IF: 16.99)
4. Hu S*, … Zhao JY#, Xu W#, Zhao SM#. Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle. Nature Metabolism 2023;5(4):626-641. (IF: 19.74)
5. Wang Y*, … Zhang X#, Zhao JY#, Hou Y#, Ding C#. Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms. Nature Communications 2023;14(1):505. (IF: 17.69)
6. Li L*, … Zhao JY#, Hou Y#, Ding C#. Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes. Nature Communications 2023;14(1):1751. (IF: 17.69)
7. Li L*, … Zhou P#, Zhao JY#, Hou Y#, Ding C#. Integrative proteogenomic characterization of early esophageal cancer. Nature Communications 2023;14(1):1666. (IF: 17.69)
8. Deng M*, … Xu C#, Shi G#, Ji Y#, Zhao JY#, Zhou J#, Fan J#, Hou Y#, Ding C#. Proteogenomic Characterization of Cholangiocarcinoma. Hepatology 2023.;77(2):411-429. (IF: 17.3)
9. Zhang X*, … Gui YH#, Zhao JY#. Gestational Leucylation Suppresses Embryonic T-Box Transcription Factor 5 Signal and Causes Congenital Heart Disease. Advanced Science. 2022; 9(15):e2201034. (IF: 17.52)
10. Cai K*, … Gui YH#, Zhao JY#. Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-CoA Hydratase 1 Deficiency. JACC-Basic to Translational Science 2022;7(4):348-362. (IF: 9.53)
11. Zhou WJ*, … Zhao JY#, Jin LP#, Li MQ#. Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2+ macrophage differentiation. Science Advances 2022;8(8):eabj2488. (IF: 14.96)
12. Li C*, … Zhao JY#, Wang H#. Master MicroRNA-222 Regulates Cardiac MicroRNA Maturation and Triggers Tetralogy of Fallot. Signal Transduction and Targeted Therapy 2022;7:165. (IF: 38.1)
13. Hu SH*, … Zhao JY#, Xu W#, Zhao SM#. Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake. Cell Reports 2022;38(11):110509. (IF: 9.99)
14. Li Y*, … Liu T#, Shen K#, Zhao JY#, Hou Y#, Ding C#. Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies. Nature Communications 2022; 29;13(1):5723. (IF: 17.69)
15. Qu Y*, … Zhang H#, Zhao JY#, Ye D#, Ding C#. A Proteogenomic Analysis of Clear Cell Renal Cell Carcinoma in a Chinese Population. Nature Communications 2022;13(1):2052. (IF: 17.69)
16. Qu Y*, … Zhao JY#, Zhang H#, Ye D#, Ding C#. Proteogenomic characterization of MiT family translocation renal cell carcinoma. Nature Communications 2022;13(1):7494. (IF: 17.69)
17. Shen Y, … Zhao JY#, Cheng L#. Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α. Cell Death & Disease 2022;13(7):643. (IF: 9.69)
18. Zhang Y*, … Jin L#, Zhao JY#, Zhou X#. Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice. Cell Death & Disease 2022;13(3):279. (IF: 9.69)
19. Zhou Y*, … Zhang Y#, Zhao JY#, Tao H#. METTL3 boosts glycolysis and cardiac fibroblast proliferation by increasing AR methylation. International Journal of Biological Macromolecules 2022;223(A):899-915. (IF: 8.03)
20. Sun H*, … Zhao JY#, Zhang Y#, Tao H#. MTHFR epigenetic derepression protects against diabetes cardiac fibrosis. Free Radical Biology and Medicine 2022;193(1):330-341. (IF: 8.1)
21. Zhang X, … Zhao JY#. Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation. Cell Reports 2021;37(2):109821. (IF: 9.99)
22. Wang XH*, … Jin LP#, Zhao JY#. Low embryonic villous succinate accumulation increases recurrent spontaneous abortion risk. Nature Communications 2021;12(1):3428. (IF: 17.69)
23. Xu S, … Zhao JY#. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduction and Targeted Therapy 2021;6(1):54. (IF: 38.1)
24. Zhang Y*, … Zhao JY#, Zhou XY#. Two sides of NNMT in alcoholic and nonalcoholic fatty liver development. Journal of Hepatology 2021;74(5):1250-1253. (IF: 30.08)
25. Xu W*, … Zhao JY#, Zhang H#, Ye D#. Adenylate cyclase-activating polypeptide 1 gene methylation predicts prognosis and the immune microenvironment of bladder cancer. Clinical and Translational Medicine 2021;11:e597. (IF: 8.55)
26. Qu YY*, … Ye DW#, Zhao SM#, Zhao JY#. Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth. Cancer Research 2020; 80(2):319-333. (IF: 13.31)
27. Mei X*, … Wang H#, Zhao JY#, Zhao S#, Xu W#. Inhibiting MARSs reduces hyperhomocysteinemia-associated neural tube and congenital heart defects. EMBO Molecular Medicine 2020; 12(3):e9469. (IF: 14.26)
28. Li Y*, … Zhao SM#, Zhao JY#. APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression. Nature Communications 2019; 10(1):2502. (IF: 17.69)
29. Wang D*, … Zhao SM#, Zhao JY#. Colonic lysine homocysteinylation induced by high-fat diet suppresses DNA damage repair. Cell Reports 2018; 25:398-412. (IF: 9.99)
30. Wang D*, … Zhao SM#, Wang H#, Zhao JY#. Lower circulating folate induced by a Fidgetin intronic variant is associated with reduced congenital heart disease Susceptibility. Circulation 2017; 135(18):1733-1748. (IF: 39.92)
31. Xu S*, … Zhao JY#, Zhao SM#. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal Transduction and Targeted Therapy 2017; 2, e16035. (IF: 38.1)
32. Zhao JY*, Liang L*, Gu X*, …Tao YX#. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nature Communications 2017; 8:14712. (IF: 17.69)
33. Xu JT*, Zhao JY*, Zhao X*, … Tao YX#. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. Journal of Clinical Investigation 2014; 124(2):592-603. (IF: 19.46)
34. Zhao JY*, Qiao B*, Duan WY*, … Huang GY#, Jin L#, Wang HY#. Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations. European Heart Journal 2014; 35(11):733-42. (IF: 35.86)
35. Zhao X*, Tang Z*, Zhang H*, Atianjoh FE*, Zhao JY*, … Tao YX#. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nature Neuroscience 2013; 16(8):1024-31. (IF: 28.77)
36. Zhao JY*, Yang XY*, Shi KH*, … Wang HY#. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population. Cell Research 2013, 23:242-253. (IF: 46.3)
37. Zhao JY*, Yang XY*, Gong XH*, … Qiao B#, Wang HY#. Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population. Circulation 2012; 125(3):482-90. (IF: 39.92)
