董建树
郑州大学药学院直聘副教授，硕士生导师。2013年中国科学院大学获博士学位，获中国科学院院长优秀奖。2014-2017年在利物浦大学生物化学系兼整合生物学研究所任Research Associate。主要研究方向：蛋白质晶体学，结构生物学，酶催化机制，开展药物靶标蛋白质等生物大分子的结构与功能研究，以及基于多种疾病相关蛋白结构的药学研究。研究成果在Angewandte Chemie International Edition，IUCrJ，Journal of Molecular Biology, European Journal of Medicinal Chemistry等高水平SCI杂志发表论文11篇；其中一作或通讯作者8篇。获得发明专利授权一项。现作为项目负责人主持国家自然科学基金项目1项。参编“十三五”国家重点图书出版规划项目《Medical Microbiology》英文教材1部。现为英国生物物理学会会员，中国生物物理学会会员。
联系方式：jdongATzzu.edu.cn
工作及教育经历
2017.7-至今 郑州大学药学院
2014.8-2017.7 利物浦大学 Research Associate
2013.7-2014.6 中国科学院 助理研究员
2008.9-2013.7 中国科学院大学 理学博士
荣誉及奖励
2013年获中国科学院院长优秀奖
2021年获河南省第五届自然科学学术奖二等奖
2022年获河南省教育厅优秀科技论文奖一等奖
指导学生情况
多次被学生评为网评优秀教师。指导大学生在“挑战杯”大学生课外学术科技作品竞赛中获奖。所指导学生分别赴武汉大学、中国药科大学、西安交通大学、兰州大学、中南大学、东南大学、中国海洋大学、UCLA(USA)、UoG(UK)等国内外著名高校继续深造。
代表性学术论文：
1. Js Dong *; Li, Fahui; Gao, Feng; Wei, Jia; Lin, Yajing; Zhang, Yong; Lou, Jizhong; Liu, Guangfeng; Dong, Yuhui; Liu, Lin; Liu, Hongmin; Wang, Jiangyun; Gong, Weimin*; Structure of tRNA Modifying Enzyme TiaS and Motions of its Substrate Binding Zinc Ribbon, Journal of Molecular Biology, 2018, 430(21): 4183-4194.
2. Js Dong; On Catalytic Kinetics of Enzymes, Processes, 2021, 9(2): 271.
3. Js Dong; Sasaki, Daisuke; Eady, Robert R; Antonyuk, Svetlana V; Hasnain, S Samar*; Identification of a tyrosine switch in copper-haem nitrite reductases, IUCrJ, 2018, 5(Part 4): 510-518.
4. Agboyibor; Clement#; Js Dong #; Effah; Clement Y; Drokow; Emmanuel K; Pervaiz; Waqar; Li; Dié; Kang; Lei; Ma; Xinli; Li; Jian; Liu; Zhenzhen; Liu; Hong-Min; Systematic Review and Meta-Analysis of Lysine-Specific Demethylase 1 Expression as a Prognostic Biomarker of Cancer Survival and Disease Progression, Cancer Control, 2021, 28: 10732748211051557.
5. A Covalent Approach for Site-Specific RNA Labeling in Mammalian Cells, F Li 1, Js Dong 1, X Hu1, W Gong, J Li, J Shen, H Tian, J Wang*, Angewandte Chemie International Edition, 2015 Feb, (1 first authors, VIPaper)
6. Genetic Incorporation of a Metal-Chelating Amino Acid as a Probe for Protein Electron Transfer, X Liu1, J Li1, Js Dong1, C Hu, W Gong, and J Wang, Angewandte Chemie International Edition, 2012 Oct , (1 first authors, cover story)
7. Crystal Structure of E. coli Arginyl-tRNA Synthetase and Ligand Binding Studies Revealed Key Residues in Arginine Recognition, K Bi, Y Zheng, F Gao, Js Dong, J Wang, Y Wang, W Gong, Protein & Cell , 2014 Feb
8. Significant Improvement of Oxidase Activity through the Genetic Incorporation of Redox-active Unnatural Amino Acids, Y Yu, Q Zhou, L Wang, X Liu, W Zhang, M Hu, Js Dong, J Li, X Lv, H Ouyang, H Li, F Gao,W Gong, Y Lu*, J Wang*, Chem. Sci., 2015
9. EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon-anticodon duplex. G Liu, G Song, D Zhang, Z Li, Z Lyu, Js Dong, J Achenbach, W Gong, XS Zhao, KH Nierhaus, Y Qin. Nat Struct Mol Biol. 2014 Sep
10. Dong Js*#, Pervaiz W#, Tayyab B, Li D, Kang L, Zhang H, Gong H, Ma X, Li J, Agboyibor C, Bi Y*, Liu H*, A comprehensive comparative study on LSD1 in different cancers and tumor specific LSD1 inhibitors, European Journal of Medicinal Chemistry, Volume 240, 2022, 114564, ISSN 0223-5234, https://doi.org/10.1016/j.ejmech.2022.114564.
11. Hussain S #, Dong Js#*, Ma X, Li J, Chen S, Agboybor C, Liu H *, F-Box Only Protein 9 and its role in Cancer, Molecular Biology Reports, 2022;49:1537-44. (#Co-first authors, *Correspondence)
会议报告:
Crystal structures of NO, nitrite complexed RpNiR provide insight into nitrite reduction mechanism catalysed by haem-c-CuNiRs，Js Dong, British Biophysical Society 2016 Biennial Meeting
国家发明专利
3-吡唑基酪氨酸翻译系统及其应用, 第四发明人，2014-02-12, 中国专利, CN201210285659.7.