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张翼 教授(Co-PI，电子科大国家青年人才)    

研究致力于通过研发微纳医疗系统来弥合技术和医学之间的鸿沟，长期从事3D打印及其在生物传感和微器件制造领域应用的研究，在复合材料3D打印、生物3D打印、3D打印新型微纳生物传感器件及诊断设备、3D打印柔性器件与微机器人等重要前沿方向上开展了深入的研究工作，并取得了一系列创新科研成果，在Advanced Materials, Advanced Functional Materials, ACS Nano及Virtual and Rapid Prototyping等增材制造、微纳工程及生物医学领域内的重要期刊上发表了70篇论文。共申请中国及国际专利50项，其中8项获得授权。3项技术共16项相关专利实现或正在进行转让/转化。其中，基于微纳多级二氧化硅膜的固液双相大分子量DNA萃取技术已完成技术转换，并被第三代测序领跑企业Pacific Biosciences收购，相关技术产品目前已成为第三代长读测序的样本制备标准方法。

  1. A. Zhou, C. Xu, P. Kanittamniyom, C.S.X. Ng, G.J. Lim, W.S. Lew, S. Vasoo, X. Zhang, G.Z. Lum, and Y. Zhang*, Magnetic Soft Millirobots 3D-Printed by Circulating Vat Photopolymerization to Manipulate Droplets Containing Hazardous Agents for in Vitro Diagnostics, Advanced Materials, 2022, 2200061, DOI: 10.1002/adma.202200061

  2. Y. Zhang*#, A. Zhou#, S. Chen, G.Z. Lum, and X. Zhang*, A Perspective on Magnetic Microfluidics – Towards An Intelligent Future, Biomicrofluidics, 2022, 16, 011301

  3. B. Xu, Y. Zhang, L. Chen, L. Yu, L. Li, and Q. Wang, The influence of social network on COVID-19 vaccine hesitancy among healthcare workers: a cross-sectional survey, Human Vaccines & Immunotherapeutics, 2021, DOI: 10.1080/21645515.2021.2004837

  4. J. W. Koo, J. S. Ho, Y. Z. Tan, W. S. Tan, J. An, Y. Zhang, C. K. Chua, and T. H. Chong, Fouling Mitigation in Reverse Osmosis Processes with 3D Printed Sinusoidal Spacers, Water Research, 2021, 207, 117818

  5. Y. Zhang#, Y. Yu#, and J. Y. Ying*, Multi-Color Au/Ag Nanoparticles for Multiplexed Lateral Flow Assay based on Spatial Separation and Color Co-Localization, Advanced Functional Materials, 2021, 2109553

  6. Y. Zhang*, A. Rogers, K. Nadeau, J. Gu, S. Yang*, A Perspective on the Role of Point-of-Care "Immuno-Triaging" to Optimize COVID-19 Vaccination Distribution in a Time of Scarcity, Frontiers in Public Health, 2021, 9, 638316

  7. Y. Shi*, K.T. Nguyen, L.K. Chin, Z. Li, L. Xiao, H. Cai, R. Yu, W. Huang, S. Feng, P. H. Yap, J. Liu*, Y. Zhang*, A.Q. Liu*, Trapping and Detection of Single Viruses in An Optofluidic Chip, ACS Sensors, 2021, 6, 3445-3450

  8. A. Y. Lee, A. Pant, P. Kanitthamniyom, C. P. Lee, J. An, M. Hashimoto, U-X. Tan, C. H. Leo, G. Wong, C.K. Chua, Y. Zhang*, Three-Dimensional Printing of Food Foams Stabilized by Hydrocolloids for Hydration in Dysphagia, International Journal of Bioprinting, 2021, 7, 4, 393

  9. S. Luo, Y. Shi, L.K. Chin, P.E. Hutchinson, Y. Zhang, G. Chierchia, H. Talbot, X. Jiang, T. Bourouina, A.-Q. Liu, Machine-Learning-Assisted Intelligent Imaging Flow Cytometry: A Review, Advanced Intelligent System, 2021, 2100073.

    P. Kanitthamniyom, P.Y. Hon, A. Zhou, M.Y. Abdad, Z.Y. Leow, N.B.M. Yazid, V. W.X Lim, S. Vasoo* and Y. Zhang*, A 3D-Printed Magnetic Digital Microfluidic Diagnostic Platform for Rapid Colorimetric Sensing of Carbapenemase-Producing Enterobacteriaceae, Microsystems and Nanoengineering, 2021, 7, 47

  10. S. Luo, Y. Shi, L.K. Chin, Y. Zhang, B. Wen, Y. Sun, B.T. Nguyen, G. Chierchia, H. Talbot, T. Bourouina, X. Jiang, A.Q. Liu, Rare Bioparticle Detection via Deep Metric Learning, RSC Advances, 2021, 11, 17603-17610fo

  11. H. Zhang, J. Thompson, M. Gu, X.D. Jiang, H. Cai, P. Y. Liu, Y. Shi, Y. Zhang, M.F. Karim, G.Q. Lo, X. Luo, B. Dong, L.C. Kwek, and A.Q. Liu, Efficient On-Chip Training of Optical Neural Networks Using Genetic Algorithm, ACS Photonics, 2021, 2021, 8, 6, 1662–1672

  12. S. Luo, K.T. Nguyen, B.T.T. Nguyen, S. Feng. Y. Shi, A. Elsayed, Y. Zhang*, X. Zhou, B. Wen, G. Chierchia, H. Talbot, T. Bourouina*, X. Jiang*, A.Q. Liu*, Deep Learning‐Enabled Imaging Flow Cytometry for High‐Speed Cryptosporidium and Giardia Detection, Cytometry Part A, 2021, 99, 1123-1133

  13. Z. Li, H. Zhang, B. Nguyen, S. Luo, P. Y. Liu, J. Zou, Y. Shi, H. Cai, Z. Yang, Y. Jin, Y. Hao, Yi Zhang*, and A.-Q. Liu*, Smart Ring Resonator-based Sensor for Multicomponent Chemical Analysis via Machine Learning, Photonics Research, 2021, 9, B38-B44

  14. H. Zhang, M. Gu, X. Jiang, J. Thompson, H. Cai, S. Paesani, R. Santogati, A. Laing, Y. Zhang, M-H. Yung, Y. Shi, M. Karim, G. Lo, X. Luo, B. Dong, D-L. Kwong, L.C. Kwek, A.Q. Liu, An Optical Neural Chip for Implementing Complex-valued Neural Network, Nature Communication, 2021, 12, 457

  15. A. Pant, A. Y. Lee, R. Karyappa, C.P. Lee, J. An, M. Hashimoto, U-X. Tan, G. Wong, C.K. Chua*, and Y. Zhang*, 3D food printing of fresh vegetables using food hydrocolloids for dysphagic patients, Food Hydrocolloids, 2021, 114, 106546

  16. H. Zhao, L.K. Chin, Y. Shi, P. Y. Liu, Y. Zhang, H. Cai, E.P.H. Yap, W. Ser, and A.Q. Liu, Continuous optical sorting of nanoscale biomolecules in integrated microfluidic-nanophotonic chips, Sensors and Actuators B: Chemical, 2021, 129428

  17. J.W. Koo, J.S. Ho, J. An, Y. Zhang, C.K. Chua, T.H. Chong, A review on spacers and membranes: Conventional or hybrid additive manufacturing? Water Research, 2021, 116497

  18. Y. Zhang*, Magnetic Digital Microfluidics for Point of Care Testing: Where Are We Now? Current Medicinal Chemistry, 2021, 28, 6323-6336

  19. S. Luo, Y. Zhang*, K.T. Nguyen, S. Feng, Y. Shi, Y. Liu, P. Hutchison, G. Chierchia, H. Talbot, T. Bourouina*, X. Jiang* and A.Q. Liu*, Machine Learning-Based Pipeline for High Accuracy Bioparticle Sizing, Micromachines, 2020, 11, 1084

  20. A. Y. Lee, A.W. Zhou, J. An, C. K. Chua*, Y. Zhang*, Contactless reversible 4D-printing for 3D-to-3D shape morphing, Virtual and Physical Prototyping, 2020, 15, 481-495

  21. Y. Shi, H. Zhao, L.K. Chin, Y. Zhang, P.H. Yap, W. Ser, C.-W. Qiu, and A.Q. Liu, Optical potential-well array for high-selectivity, massive trapping and sorting at nanoscale, Nano Letters, 2020, 20, 7, 5193–5200

  22. S.Y. Chin, V. Dikshit, B.M. Priyadarshini, and Y. Zhang*, Powder-Based 3D Printing for the Fabrication of Device with Micro and Mesoscale Features, Micromachine, 2020, 11, 658

  23. B. M. Priyadarshini, V. Dikshit, and Y. Zhang*, 3D-Printed Bioreactors for in vitro Modeling and Analysis, International Journal of Bioprinting, 2020, 6, 267

  24. L. Cao, W. Luo, Y. X. Wang, J. Zou, R. D. Yan, H. Cai, Y. Zhang, X. L. Hu, C. Jiang, W. J. Fan, X. Q. Zhou, B. Dong, X. S. Luo, G. Q. Lo, Y. X. Wang, Z. W. Xu, S. H. Sun, X. B. Wang, Y. L. Hao, Y. F. Jin, D. L. Kwong, L. C. Kwek and A. Q. Liu, Chip-Based Measurement-Device-Independent Quantum Key Distribution Using Integrated Silicon Photonic Systems, Physical Review Applied, 2020, 14, 011001

  25. Y. Shi, T. Zhu, K.T. Nguyen, Y. Zhang, S. Xiong, P.H. Yap, W. Ser, S. Wang, C.-W. Qiu, C.T. Chan, and A.Q. Liu, Optofluidic Microengine in A Dynamic Flow Environment via Self-Induced Back-Action, ACS Photonics, 2020, 7, 6, 1500–1507

  26. P. Kanitthamniyom, A. Zhou, S. Feng, A.-Q. Liu, S. Vasoo, Y. Zhang*, A 3D-Printed Modular Magnetic Digital Microfluidic Architecture for On-Demand Bioanalysis, Microsystems & Nanoengineering, 2020, 6, 48 (Featured Article)

  27. H. Zhao, L. K. Chin, Y. Shi, K.T. Nguyen, P. Y. Liu, Y. Zhang, M. Zhang, J. Zhang, H. Cai, P.H. Yap, W. Ser, A.-Q. Liu, Massive nanophotonic trapping and alignment of rod-shaped bacteria for parallel single-cell studies, Sensors and Actuators B: Chemical, 2020, 306, 127562

  28. R. Wang, Q. Zhang, Y. Zhang, Shi H., Nguyen K.T., Zhou X., Unconventional Split Aptamers Cleaved at Functionally Essential Sites Preserve Biorecognition Capability, Analytical Chemistry, 2019, 91, 15811-15817

  29. Y.Z. Shi, H.T. Zhao, K.T. Nguyen, Y. Zhang*, L.K. Chin, T.T. Zhu, Y.F. Yu, H. Cai, P.H. Yap, P.Y. Liu, S. Xiong, J.B. Zhang, C.-W. Chen, C.T. Chan, A.Q. Liu*, Nanophotonic Array-Induced Dynamic Behavior for Label-Free Shape-Selective Bacteria Sieving, ACS Nano, 2019,13,12070-12080

  30. Y. Zhang* and Tza-Huei Wang*, Rapid Generation of Chemical Combinations on A Magnetic Digital Microfluidic Array, RSC Advances, 2019, 9, 21741 – 21747

  31. Y. Zhang*, Three-Dimensional-Printing for Microfluidics or the Other Way Round, International Journal of Bioprinting, 2019, 5, 192

  32. A. Y. Lee*, J. An, C.K. Chua*, Y. Zhang, Preliminary investigation of reversible 4D printing of dual layer component, Engineering, 2019, 5, 1159-1170

  33. S.L. Voon, J. An, G. Wong, Y. Zhang and C.K. Chua, 3D Food Printing: A Categorised Review of Inks and Their Development, Virtual and Physical Prototyping, 2019, 14, 203-218

  34. Y. Zhang*, A. Hu, N. Andini, and S. Yang*, A 'Culture' Shift: Application of Molecular Techniques for Diagnosing Polymicrobial Infections, Biotechnology Advances, 2019, 37, 476-490

  35. P. Kanitthamniyom and Y. Zhang*, Magnetic Digital Microfluidics on A Bioinspired Surface for Point-of-Care Diagnostics of Infectious Disease, Electrophoresis, 2019, 40, 1178-1185 (Cover Page Article)

  36. Y. Zhang, D.Y.S. Lee, A. Farwin, J.Y.Ying, Sieve-Through Vertical Flow Platform for Efficient Liquid Exchange in Particle-Based Assays, Analytica Chimica Acta, 2019, 1051, 94-102

  37. H.T. Zhao, Y. Zhang*, P.Y. Liu, P.H. Yap, W. Ser*, and A. Q. Liu*, Chemical Reaction Monitoring via the Light Focusing in Optofluidic Waveguides. Sensors and Actuators B: Chemical, 2019, 280, 16-23

  38. Y.Z. Shi, S. Xiong, Y. Zhang, L.K. Chin, Y.-Y. Chen, J.B. Zhang, T.H. Zhang, W. Ser, A. Larson, L.S. Hoi, J.H. Wu, T.N. Chen, Z. C. Yang, Y. L. Hao, B. Liedberg, P.H. Yap, D.P. Tsai, C.-W. Qiu and A.Q. Liu, Sculpting Nanoparticle Dynamics for Single Bacteria-Level Screening and Direct Binding Efficiency Measurement, Nature Communications, 2018, 9, 815

  39. P. Kanitthamniyom and Y. Zhang*, Application of Polydopamine in Biomedical Microfluidic Devices, Microfluidics and Nanofluidics, 2018, 22:24

  40. Y. Shi, S. Xiong*, L.K. Chin, Y. Yang, J. Zhang, W. Ser, J.H. Wu, T. Chen, Z. Yang, Y. Hao, B. Liedberg, P.H. Yap, Y. Zhang* and A.Q. Liu*, High-Resolution and Multi-Range Particle Separation by Microscopic Vibration in An Optofluidic Chip, Lab on a Chip, 2017, 17, 2443-2450 (Cover Page Article)  

  41. Y. Zhang*, Post-Printing Surface Modification and Functionalization of 3D-printed Biomedical Device, International Journal of Bioprinting, 2017, 3, 1-7

  42. Y. Zhang* and N.T. Nguyen, Magnetic Digital Microfluidics–A Review, Lab on a Chip, 2017,17, 994-1008 (Cover Article)

  43. Y. Zhang#, Y. Zhang#, J.M. Burke, K. Gleitsman, S.M. Friedrich, K.J. Liu and T.H. Wang, A Simple Thermoplastic Substrate Containing Hierarchical Silica Lamellae for High-Molecular-Weight DNA Extraction, Advanced Materials, 2016, 28, 10630-10636 (#Equal Contribution) (Cover Page Article)

  44. Y. Zhang and J.Y. Ying, Homogeneous Immunochemical Assay on the Lateral Flow Strip for Measurement of DNase I Activity, Analytical Chemistry, 2015, 87, 10193-10198

  45. Y. Zhang, J. Bai, H. Wu, and J.Y. Ying, Trapping Cells in Paper for White Blood Cell Count, Biosensors and Bioelectronics, 2015, 69, 121-127

  46. Y. Zhang, J. Bai and J.Y. Ying, Stacking Flow Immunoassay for the Detection of Dengue Specific Immunoglobulins in Salivary Fluid, Lab on a Chip, 2015,15, 1465-1471

  47. Y. Zhang and T.H. Wang, High-resolution quantification by charge-dominant electrophoretic mobility shift of quantum dots, Electrophoresis, 2015, 36,1011-1015

  48. D.J. Shin#, Y. Zhang# and T.H. Wang, A droplet microfluidic approach to single-stream nucleic acid isolation and mutation detection, Microfluidics and Nanofluidics, 2014, 17, 425-440 (#Equal Contribution)

  49. Y. Zhang, D.J. Shin, and T.H. Wang, Serial Dilution via Surface Energy Trap-Assisted Magnetic Droplet Manipulation, Lab on a Chip, 2013,13, 4827-4831

  50. B. Keeley, A. Stark, T.R. Pisanic II, R. Kwak, Y. Zhang, J. Wrangle, S.B. Baylin, J.G. Herman, N. Ahuja, M.V. Brock, T.H. Wang, Extraction and Processing of Circulating DNA from Large Sample Volumes Using Methylation on Beads for The Detection of Rare Epigenetic Events, Clinica Chimica Acta, 2013, 425, 169-175

  51. C.H. Chiou, D.J. Shin, Y. Zhang and T.H. Wang, Topography-Assisted Electromagnetic Platform for Blood-to-PCR in a Droplet, Biosensors and Bioelectronics, 2013, 50, 91-99

  52. Y. Song, Y. Zhang, and T.H. Wang, Single Quantum Dot Analysis Enables Multiplexed Point Mutation Detection by Gap Ligase Chain Reaction, Small, 2013, 9, 1096-1105

  53. Y. Zhang and T.H. Wang, Full-Range Magnetic Manipulation of Droplets via Surface Energy Traps Enables Complex Bioassay, Advanced Materials, 2013, 25, 2903-2908 (Featured as Art in Science Award winner on the cover page of Lab on a Chip)

  54. Y. Zhang, K.J. Liu, T.L. Wang, I.M. Shih, and T.H. Wang, Mapping DNA Quantity into Electrophoretic Mobility through Quantum Dot Nanotethers for High Resolution Genetic and Epigenetic Analysis, ACS Nano, 2012, 6, 858–864 (Highlighted in ACS Nano Podcast, Featured in BioTechniques, 2012, 52, 127-127)

  55. Y. Zhang and T.H. Wang, Micro Magnetic Gyromixer for Speeding up Reactions in Droplets, Microfluidics and Nanofluidics, 2013, 12, 787-794. (Featured as Art in Science Award winner on the cover page of Lab on a Chip)

  56. Y. Zhang and T.H. Wang, Quantum Dot for Molecular Sensing and Diagnostics, Theranostics, 2012, 2, 631-654  

  57. S. Park, Y. Zhang, S. Lin, T.H. Wang and S. Yang, Advances in Microfluidic PCR for Point-of-Care Infectious Disease Diagnostics, Biotechnology Advances, 2011, 29, 830-900

  58. Y. Zhang, S. Park, K.J. Liu, J. Tsuan, S. Yang and T.H. Wang, A Surface Topography Assisted Droplet Manipulation Platform for Biomarker Detection and Pathogen Identification, Lab on a Chip, 2011, 11, 398-406 (Cover Page Article)

  59. K.J. Liu, T.D. Rane, Y. Zhang and T.H. Wang, Single-Molecule Analysis Enables Free Solution Hydrodynamic Separation Using Yoctomole Levels of DNA, Journal of the American Chemical Society, 2011, 133, 6898–6901)

  60. S. Park, Y. Zhang, T.H. Wang and S. Yang, Continuous Dielectrophoretic Bacterial Separation and Concentration from Physiological Media of High Conductivity, Lab on a Chip, 2011, 11, 2893-2900

  61. Y. Zhang, S. Park, S. Yang and T.H. Wang, An All-in-one Microfluidic Device for Parallel DNA Extraction and Gene Analysis, Biomedical Microdevices, 2010, 12, 1043-1049

  62. V.J. Bailey, # Y. Zhang, # B.P. Keeley, C. Yin, K.L. Pelosky, M. Brock, S.B. Baylin, J.G. Herman, and T.H. Wang, Single-Tube Analysis of DNA Methylation with Silica Superparamagnetic Beads, Clinical Chemistry, 2010, 6, 1022-1025 (#Equal Contribution)

  63. T. D. Rane, C. M. Puleo, K. J. Liu, Y. Zhang, A. P. Lee and T. H. Wang, Counting Single Molecules in Sub-Nanolitre Droplets, Lab on a Chip, 2010, 10, 161 - 164

  64. Y. Zhang, V.J. Bailey, C.M. Puleo, H. Easwaran, E. Griffiths, J.G. Herman, S.B. Baylin and T.H. Wang, DNA Methylation Analysis on A Droplet-in-oil PCR Array, Lab on a Chip, 2009, 9, 1059 – 1064 (Cover page article)

  65. V.J. Bailey, B.P. Keeley, Y. Zhang, Y.P. Ho, H. Easwaran, M.V. Brock, K.L. Pelosky, H.E. Carraway, S.B. Baylin, J.G. Herman, T.H. Wang, Enzymatic Incorporation of Multiple Dyes for Increased Sensitivity in QD-FRET Sensing for DNA Methylation Detection, ChemBioChem, 2009, 11, 71-74

  66. V.J. Bailey, H. Easwaran, Y. Zhang, E. Griffiths, S.A. Belinsky, J.G. Herman, S.B. Baylin, H.E. Carraway, and T.H. Wang. MS-qFRET: A Quantum Dot-Based Method for Analysis of DNA Methylation, Genome Research. 2009, 9,1455-1461

  67. J. Pipper, Y. Zhang, P. Neuzil, and T.M. Hsieh, Clockwork PCR Including Sample Preparation. Angewandte Chemie International Edition in English, 2008, 47, 3900-3904

  68. J. Pipper, L. Ng, M. Inoue, P. Neuzil, Y. Zhang, L. Novak, and T.M. Hsieh, Catching Bird Flu in A Droplet, Nature Medicine, 2007, 13, 1259 - 1263. (Featured in Nature Nanotechnology, Top down bottom up: Connecting people, Nat. Nanotech, 2007, 2, 669)

  69. L. Novak, P. Neuzil, J. Pipper, Y. Zhang, and S. Lee, An Integrated Fluorescence Detection System for Lab-On-A-Chip Applications, Lab on a Chip, 2007, 7, 27 - 29