张文成，男，1986年6月生，再生医学博士，上海市卫生系统副研究员，上海市东方医院（同济大学附属东方医院）再生医学研究所副研究员，同济大学生科院硕士生导师，上海市浦江人才。国际学术期刊Life Research编委、Frontiers in Cell and Developmental Biology杂志客座副主编；Hepatology、Tissue Engineering、International Journal of Molecular Sciences、International Immunopharmacology特邀审稿人，上海干细胞转化医学工程技术研究中心科研秘书，中国整形美容协会干细胞研究与应用分会青年工作委员会委员，同济大学东方临床医学院生物技术教研室教学团队成员。
2007年毕业于西北农林科技大学生物科学专业，同年考入军事医学科学院，从事体细胞重编程和组织再生研究。2012年获得再生医学博士学位，以助理研究员继续从事基于干细胞的肝再生的研究。2014年11月赴美国北卡罗来纳大学教堂山分校（UNC-Chapel Hill）医学院Lola M. Reid教授实验室开展博士后训练，主要从事胆管树干细胞体外扩增、干细胞向实体脏器高效移植、纤维板层型肝癌研究。2019年2月以研究助理在UNC-Chapel Hill医学院Lola M. Reid教授实验室和药学院Jian Liu教授的实验室，开展合成硫酸乙酰肝素在胆管树干细胞和纤维板层型肝癌中应用的研究。回国后主持国家级和省部级项目4项，近年来在Cell Stem Cell、Journal of Hepatology、Hepatology、Biomaterials等本领域国际核心期刊SCI收录论文18篇，发表文章总影响因子178.838，其中第一、通讯（含共同）文章总影响因子122.61，发表文章被引次数：300次。参编（译）书籍中文、英文4部；获批中国和美国国家发明专利8项，其中PCT专利3项。多次参加国际会议次，受邀在2018年的Proteoglycan GRC会议、2021年的第四界世界细胞治疗大会（WRC-CHINA ）中进行大会报告。
二、研究方向
1、补片移植治疗终末期肝病
2、基于糖胺聚糖的胆管树干细胞体外扩增和肝向分化成熟
3、纤维板层型肝癌模型建立和机制探讨
三、 基金项目
1、国家自然科学基金面上项目，82270638，透明质酸调节MMP2-TIMP3平衡实现补片移植胆管树干细胞救治肝衰竭，2023.01-2026.12，52万，项目负责人，在研。
2、上海市浦江人才计划，21PJD059，胆管树干细胞补片移植治疗终末期肝病的应用研究，2021.10-2023.09，30万，项目负责人，在研。
3、上海市2022年度“科技创新行动计划”自然科学基金项目，22ZR1451100，3-O硫酸乙酰肝素促进胆管树干细胞肝向分化成熟的机制和应用研究，2022.04-2025.03，20万，项目负责人，在研。
4、国家重点研发计划“干细胞及转化研究”重点专项，2020YFA0112603，基于微载体的肝前体细胞的规模化扩增，2020.10-2024.12，56.87万元，子课题负责人，在研。
四、 近期发表文章
(1) Wencheng Zhang1#, Yongmei Xu2#, Xicheng Wang3#, Tsunekazu Oikawa, Guowei Su, Eliane Wauthier, Guoxiu Wu2-4, Praveen Sethupathy, Zhiying He3*, Jian Liu2*, and Lola M. Reid1*. Fibrolamellar Carcinomas can be regulated by Paracrine Signals complexed with synthetic Heparan Sulfate Oligosaccharides. Implications for synthetic Glycosaminoglycans in Chemotherapy. Submitted. First or corresponding senior authors on 1stem cell biology and matrix biology and chemistry. 2glycosaminoglycan chemistry; 3bioinformatics analyses. Matrix Biology. Accepted June 29th https://doi.org/10.1016/j.matbio.2023.06.008 (Impact factor 6.9/Q1)
(2) Wencheng Zhang#, Xicheng Wang#, Giacomo Lanzoni, Eliane Wauthier, Sean Simpson, Jennifer Ashley Ezzell, Amanda Allen, Caroline Suitt, Jonah Krolik, Alexander Jhirad, Juan Dominguez-Bendala, Vincenzo Cardinale, Domenico Alvaro, Diletta Overi, Eugenio Gaudio, Praveen Sethupathy*, Guido Carpino*, Christopher Adin*, Jorge Piedrahita*, Kyle Mathews*, Zhiying He*, and Lola M. Reid*. A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans. 2023. npj Regenerative Medicine. Accepted March27th, 2023. DOI : 10.1038/s41536-023-00303-5 (Impact factor 7.2/Q1)
(3) Wencheng Zhang#, Yangyang Cui#, Yuan Du#, Yong Yang#, Ting Fang#, Fengfeng Lu, Weixia Kong, Canjun Xiao, Jun Shi, Lola M. Reid* and Zhiying He*. Liver cell therapies: cellular sources and grafting strategies. 2023. Frontiers of Medicine. Accepted April 27th, 2023. https://doi.org/10.1007/s11684-023-1002-1 (Impact factor 8.1/Q1)
(4) Yong Yang#, Wencheng Zhang#, Xicheng Wang, Jingxian Yang, Yangyang Cui, Haimeng Song, Weiping Li, Wei Li, Le Wu, Yao Du, Zhiying He*, Jun Shi*, Jiangnan Zhang*. A passage-dependent network for estimating the in vitro senescence of mesenchymal stromal/stem cells using microarray, bulk and single cell RNA sequencing. 2023. Frontiers in Cell and Developmental Biology. DOI: 10.3389/fcell.2023.998666 Accpeted on 1/26/2023 (Impact factor 5.5/Q1)
(5) Vincenzo Cardinale#, Guido Carpino#, Diletta Overi, Samira Safarikia, Wencheng Zhang, Matt Kanke, Antonio Franchitto, Daniele Costantini, Olga Riccioni, Lorenzo Nevi, Michele Chiappetta, Paolo Onori, Yu-Han Hung, Quirino Lai, Ilaria Zizzari, Marianna Nuti, Massimo Rossi, Praveen Sethupathy, Lola M. Reid, Domenico Alvaro, Eugenio Gaudio. Human duodenal submucosal glands contain a defined stem/progenitor subpopulation with liver-specific regenerative potential. Journal of Hepatology 2022 Sep 8;S0168-8278(22)03068-9. http://doi:org/10.1016/j.jhep.2022.08.037 . (Impact factor 30.083)
(6) Wencheng Zhang, Eliane Wauthier, Giacomo Lanzoni, Homayoun Hani, Xianwen Yi, Diletta Overi, Lei Shi, Sean Simpson, Amanda Allen, Carolyn Suitt, Jennifer Ashley Ezzell, Domenico Alvaro, Vincenzo Cardinale, Eugenio Gaudio, Guido Carpino, Glenn Prestwich, Juan Dominguez-Bendala, David Gerber, Kyle Mathews, Jorge Piedrahita, Christopher Adin, Praveen Sethupathy, Zhiying He, and Lola M. Reid. Patch Grafting of Organoids of Stem/progenitors into Solid Organs Can Correct Genetic-Based Disease States. Biomaterials, 2022; 121647. http://doi.org/10.1016/j.biomaterials.2022.121647 . Available online 7 August 2022. (Impact factor 14/Q1)
(7) Wenjian Chen#, Wencheng Zhang#, Miaomiao Chen, Chao Yang, Ting Fang, Haifeng Wang, Lola M. Reid, He Zhiying. Applications and Mechanisms of CDK4/6 Inhibitor PD-0332991. Cell Oncol (Dordr). 2022 Sep 10， https://doi.org/10.1007/s13402-022-00714-4. (Impact factor 6.6/Q2)
(8) Wencheng Zhang, Guido Carpino, Kirk J. Wangensteen, Hexin Yan and Zhiying He. Editorial: Cell Therapy, Liver Diseases, and Regeneration. Frontiers in Cell and Developmental Biology 2022 Sep 5;10:999305. http://doi:10.3389/fcell.2022.999305. (Impact factor 5.5/Q1)
(9) Wencheng Zhang, Yan-Ru Lou, Jianjun Zhou, Zhiying He. Editorial: Stem cells in Tissue Homeostasis and Disease. Frontiers in Cell and Developmental Biology 2022; 876060. http://doi:10.3389/fcell.2022.876060 . eCollection 2022. Mar 9. (Impact factor 5.5/Q1)
(10) Yuan Du#, Wencheng Zhang#, Hua Qiu#, Canjun Xiao, Jun Shi*, Lola M Reid*, Zhiying He*. Mouse Models of Liver Parenchyma Injuries and Regeneration. Frontiers in Cell and Developmental Biology, 2022; 3: 903740. http://doi:10.3389/fcell.2022.903740 eCollection 2022. May 3. (Impact factor 5.5/Q1)
(11) Wencheng Zhang, Giacomo Lanzoni, Homayoun Hani, Diletta Overi, Vincenzo Cardinale, Sean Simpson, Wendy Pitman, Amanda Allen, Xianwen Yi, Xicheng Wang, David Gerber, Glenn Prestwich, Oswaldo Lozoya, Eugenio Gaudio, Domenico Alvaro, Debra Tokaz, Juan Dominguez-Bendala, Christopher Adin, Jorge Piedrahita, Kyle Matthews, Praveen Sethupathy, Guido Carpino, Zhiying He, Eliane Wauthier and Lola M Reid. Patch Grafting, Strategies for Transplantation of Organoids into Solid Organs such as Liver. Biomaterials, 2021;121067. http://doi:10.1016/j.biomaterials.2021.121067 Epub 2021 Aug 25. (Impact factor 15.304)
(12) Xicheng Wang#, Wencheng Zhang#, Yong Yang, Jiansong Wang, Hua Qiu, Lijun Liao, Tsunekazu Oikawa, Eliane Wauthier, Praveen Sethupathy*, Lola M Reid*, Zhongmin Liu *, Zhiying He*. A MicroRNA-Based Network Highlights the Crucial Role of PI3K/AKT Signaling for Human Hepatic Lineage Maturation. Frontiers in Cell and Developmental Biology, 2021; 9: 670059. Http://doi:10.3389/fcell.2021.670059. eCollection 2021. Jun 1. (Impact factor 6.081)
(13) Fengfeng Lu#, Xin Pan#, Wencheng Zhang#, Xin Su, Yuying Gu, Hua Qiu, Shengwei Shen, Changcheng Liu, Wei Liu, Zhenzhen Zhan, Zhongmin Liu*, Zhiying He*. A Three-dimensional Imaging Method of Quantification and Localization for Dynamic Cell Tracking Post-transplantation. Frontiers in Cell and Developmental Biology, 2021 /fcell.2021.698795 http://doi:10.3389/fcell.2021.698795 . eCollection 2021 Sep 7. (Impact factor 6.081)
(14) Yunfang Wang#*, Jinhua Qin#, Shuyong Wang #, Wencheng Zhang #, Jialei Duan, Jing Zhang, Xin Wang, Fang Yan, Mingyang Chang, Xiaofang Liu, Bo Feng, Jiang Liu, Xuetao Pei*. Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules. Cell Stem Cell, 2016; 6;19(4):449-461. Http://doi:10.1016/j.stem.2016.06.006 . Epub 2016 Jul 21. (Impact factor 22.387)
(15) Wencheng Zhang, Hailei Yao, Sihan Wang, Shuangshuang Shi, Yang Lv, Lijuan He, Xue Nan, Wen Yue, Yanhua Li*, Xuetao Pei*. Wnt3a is involved in the early stage of miPSC and mESC haemopoietic differentiation. Cell Biol International, 2012; 36(3): 267-71. Http://doi:10.1042/CBI20100766 . 2012 Mar 1. (Impact factor 1.747)
(16) Fang Yan#, Yi Wang#, Wencheng Zhang, Mingyang Chang, Zhiying He, Jinbo Xu, Changzhen Shang, Tao Chen, Jiang Liu, Xin Wang, Xuetao Pei, Yunfang Wang. Human ES Cell-derived Hepatoblasts are an Optimal Lineage Stage for HCV Infection. Hepatology, 2017; 66(3):717-735. http://doi:10.1002/hep.29134 Epub 2017 Jul 27. (Impact factor 13.246)
(17) Haiyun Pei #, Chao Zhai #, Huilin Li, Fang Yan, Jinhua Qin, Hongfeng Yuan, Rui Zhang, Sihan Wang, Wencheng Zhang, Mingyang Chang, Yunfang Wang*, Xuetao Pei*. Connexin 32 and connexin 43 are involved in lineage restriction of hepatic progenitor cells to hepatocytes. Stem Cell Res Ther, 2017; 7;8(1):252. http://doi:10.1186/s13287-017-0703-2 . 2017 Nov 7. (Impact factor 4.963)
(18) Jing Wang #, Shang Wang #, Wencheng Zhang, Tao Wang, Peiyao Li, Xiaoling Zhao, Chao Niu, Ying Liu, Xinxing Wang, Qiang Ma *. Proteomic profiling of heat acclimation in cerebrospinal fluid of rabbit. J Proteomics, 2016; 20; 144:113-122. http://doi:10.1016/j.jprot.2016.04.028 . Epub 2016 May 18. (Impact factor 3.941)
五、 编写专著
(1) Lou, Y.-R., Zhang, W., Zhou, J., He, Z., eds. (2022). Stem cells in Tissues. Homeostasis and Disease. Lausanne: Frontiers Media SA. Http://doi:10.3389/978-2-88974-801-3 ; ISSN 1664-8714; ISBN 978-2-88974-801-3.
(2) Wencheng Zhang, Amanda Allen, Eliane Wauthier, Xianwen Yi, Homayoun Hani, Praveen Sethupathy, David Gerber, Vincenzo Cardinale, Guido Carpino, Juan Dominguez‐Bendala, Giacomo Lanzoni, Domenico Alvaro, Eugenio Gaudio, Lola Reid. Stem Cell‐Fueled Maturational Lineages in Hepatic and Pancreatic Organogenesis. In The Liver (eds I.M. Arias, H.J. Alter, J.L. Boyer, D.E. Cohen, D.A. Shafritz, S.S. Thorgeirsson and A.W. Wolkoff).2020; 521-538. ISBN: 978-1-119-43682-9.
(3) Jing Zhang, Yanhua Li, Xiaoyan Xie, Wencheng Zhang, Xuetao Pei. Regulation of Transcription Factors in Stem Cell Totipotency: The Role of Transcription Factors in iPS Cells, In Regenerative Medicine - Theory and Technology Science Press, 72-79 2010. ISBN 978-7-03-027266-9.
(4) Computational Epigenetics in Human Diseases, Cell Differentiation, and Cell Reprogramming, Volume II. Zuo, Y., Zhou, M., Su, J., Zhang, X., eds. (2022). Today’s Nutrition and Tomorrow’s Public Health: Challenges and Opportunities. Lausanne: Frontiers Media SA. Http://doi:10.3389/978-2-88974-777-1 .
六、 专利
（1）王韫芳，王术勇，张文成，覃金华。将消化道来源上皮细胞重编程为内胚层干/祖细胞的小分子化合物组合、重编程试剂盒（申请日：2017-08-29，申请号：CN107099499A，授权日：2021-02-02，专利号：ZL201710389705.0；失效日 2037-05-27）。
（2）王韫芳，王术勇，张文成，覃金华，王璇，常铭洋，闫舫，裴雪涛。将消化道来源上皮细胞重编程为内胚层干/祖细胞的方法及应用（申请日：2014-09-08，申请号：CN107142240A；授权日：2021-01-29，专利号：ZL201710389711.6；失效日 2037-05-27）。
（3）王韫芳，王术勇，张文成，覃金华，王璇，常铭洋，闫舫，裴雪涛。由消化道来源上皮细胞重编程获得的内胚层干/祖细胞的传代方法及应用（申请日：2021-07-23，申请号：CN113151157A；授权日：2022-06-28；失效日 2037-05-27）。
（4）Lola M. Reid, Wencheng Zhang, Eliane Wauthier. Patch graft compositions for cell engraftment. （申请日：2018-06-12，申请号US16006464；授权日：2021-09-28，公开号: US11129923B2；失效日 2038-06-12）。
（5）何志颖，刘中民，王喜城，张文成。评估肝谱系细胞成熟度的标志物、双组学试剂盒及构建方法（申请日：2021-03-24，申请号：CN113106160A，授权日：2022-09-05）。
（6）国际PCT专利：Wencheng Zhang, Eliane Wauthier, Lola M. Reid. Patch graft compositions for cell engraftment（申请日：2018-06-11，申请号：PCT/US2018/036960；公开日：2018-12-20，公开号: PCT: WO2018231726A1；失效日 2038-06-11）。已获美国、中国、日本、澳大利亚、欧洲等国家和地区授权。
（7）国际PCT专利：Lola M. Reid, Wencheng Zhang, Eliane Wauthier. Patch grafting of stem/progenitors into solid organs. （申请日：2020-05-22，申请号：PCT/US2020/034250；公开日：2020-12-03，公开号：WO2020242952A1；失效日：2040-05-22）。
（8）国际PCT专利：Yunfang Wang, Shuyong Wang, Wencheng Zhang, Jinhua Qin,Xuan Wang, Mingyang Chang, Fang Yan, Xuetao Pei. Small molecule compound combination for reprogramming digestive tract derived epithelial cells to endodermal stem/progenitor cells, reprogramming method and application（申请日：2017-05-27，申请号：PCT/CN2017/086336; 公开日：2017-12-07；公开号：WO2017206837A1，失效日：2023-05-27）。已获美国（US11149253B2）、日本、欧洲（EP2017805782）等国家或地区授权。
（9）张文成，何志颖，崔洋洋。胆管树干细胞的扩增或传代体系及其应用（申请日：2023-04-07，申请号：202310369365.0）
（10）何志颖，刘中民，王喜城，张文成，吴国秀，崔洋洋。一种生物样本信息的处理方法、系统以及存储介质（申请日：2023-04-18，申请号：202310414041.4）