先后在华中科技大学和芬兰赫尔辛基大学获得医学学士、硕士和博士学位。2012年-2017年在芬兰科学院和芬兰奥博大学任研究员和助理教授。2017年以“百人计划”学术带头人加入中山大学，入选深圳市海外高层次人才，现任中山大学药学院（深圳）副教授、临床药学与管理药学教研室副主任。目前担任广东省消化系统恶性肿瘤防治研究重点实验室核心成员；深圳市药学会药理学专业委员会常务委员；深圳市生物医药促进会细胞外囊泡专委会副主任委员；广东省免疫学会移植免疫分会委员、广东省精准医学应用学会疾病模型分会类器官学组学术委员；广州市外泌体产学研技术创新联盟副理事长；甘肃省生物工程学会智库专家；芬兰华人科技协会特聘专家。
长期致力肿瘤与炎症免疫性疾病的靶点发现和分子机制研究，并在研究中运用了高通量高内涵筛选、CRISPR遗传文库药物靶点筛选、蛋白质组学筛选、单细胞转录组学等多种新技术新方法。近年聚焦于细胞外囊泡免疫调控领域研究，搭建了完善的动植物和微生物细胞外囊泡（外泌体）提取纯化、鉴定技术平台以及质量控制平台，并探索外泌体修饰和载药技术在自身免疫病、器官移植免疫排斥、组织损伤修复等适应症中的应用，取得了一系列原创性成果。近年来在Journal of Extracellular Vesicles, ACS Nano, EMBO Mol Med, PLOS Biology, PNAS, Cell, Cell Host Microbe, PloS Pathogens, Cell Death and Differentiation，Cell Death and Disease，Acta Biomaterialia, Advanced Science等杂志发表SCI论文50多篇，影响因子累计500多点，被引次数超2000次。申报获批国家发明专利和PCT专利14项，主持包括芬兰科学院基金、国家自然科学基金、广东省国际科技合作项目、深圳市基础研究重点项目、呼吸疾病国家重点实验室基金、中央高校重点项目培育基金等在内20余项科研项目。
近年来，主编《药物发展史》和《干细胞与再生医学（英文）》教材2部；编译《外泌体的生物学功能》专著1部；主持录制《医学生物学》慕课1项，获中山大学药学院（深圳）第一届师德师风先进典型，2021年中山大学优秀班主任，2021年第九届中山大学教学竞赛初赛一等奖、决赛优胜奖等荣誉和称号。培养的研究生连续三年获得省级优秀学生、校级优秀毕业生和优秀博士毕业论文等荣誉。被国际知名杂志如Cancer Research, Advance Science, Small, Biomaterials等邀请为审稿人，并任国际细胞外囊泡协会会刊JEV和FiCDB编委。
代表论著
# co-first author; * co-correspondence author.
1. Rufan Huang, Bo Jia, Dandan Su, Manchun Li, , Zhanxue Xu, Chao He, Yisheng Huang, Hang Fan, Hongbo Chen*, Fang Cheng*, Plant exosomes fused with engineered mesenchymal stem cell-derived nanovesicles for synergistic therapy of autoimmune skin disorders, Journal of Extracellular Vesicles, online (IF=25.8)
2. Lifang Xi, Linglu Wang, Manqi Zhang, Chao He, Xinrui Yang, Yuxin Pang, Hongbo Chen*, Fang Cheng*, TNF-R1 Cellular Nanovesicles Loaded on the Thermosensitive F-127 Hydrogel Enhance the Repair of Scalded Skin, ACS Biomater Sci Eng. [published online ahead of print, 2023 Apr 12] (IF=5.8)
3. Yu Zhang, Manqi Zhang, Amin Yao, Yalin Xie, Jingxiong Lin, Farooqi Sharifullah, Yixin Hong, Hongbo Chen, Fang Cheng*, Wei Lai*，Circ_0011129 Encapsulated by the Small Extracellular Vesicles Derived from Human Stem Cells Ameliorate Skin Photoaging，Int J Mol Sci. 2022 Dec; 23(23): 15390. (IF= 6.2)
4. Ponnuswamy Mohanasundaram, Leila S Coelho Rato, Mayank Modi, Marta Urbanska, Franziska Lautenschläger, Fang Cheng, John E Eriksson*, Cytoskeletal vimentin regulates cell size and autophagy through mTORC1 signaling, Plos Biology 2022,13;20(9):e3001737 (IF= 9.593)
5. Yury Brusentsev, Peiru Yang, Alistair W. T. King, Fang Cheng, Maria F. Cortes Ruiz, John E. Eriksson, Ilkka Kilpeläinen, Stefan Willför, Chunlin Xu*, Lars Wågberg, and Xiaoju Wang*, Photocross-Linkable and Shape-Memory Biomaterial Hydrogel Based on Methacrylated Cellulose Nanofibres, Biomacromolecules, 2023 Aug 14;24(8):3835-3845. (IF=6.2)
6. Hualian Zha#, Zhanxue Xu#, Xichao Xu#, Xingyu Lu, Peilin Shi, Youmei Xiao, Hsiang-I Tsai, Dandan Su, Fang Cheng*, Xiaoli Cheng*,* Hongbo Chen*，PD-1 Cellular Nanovesicles Carrying Gemcitabine to Inhibit the Proliferation of Triple Negative Breast Cancer Cell，Pharmaceutics 2022, 14(6), 1263 (IF= 6.525)
7. Youmei Xiao, Zhanxue Xu, Yuan Cheng, Rufan Huang, Yuan Xie, Hsiang-i Tsai, Hualian Zha, Lifang Xi, Kai Wang, Xiaoli Cheng, Yanfeng Gao, Changhua Zhang*, Fang Cheng*, Hongbo Chen*, Fe3+-binding transferrin nanovesicles encapsulating sorafenib induce ferroptosis in hepatocellular carcinoma, Biomaterials research, Biomater Res. 2023 Jul 1;27(1):63. (IF=11.27)
8. Linglu Wang#, Ponnuswamy Mohanasundaram, Michelle Lindström, Muhammad Nadeem Asghar, Giulia Sultana, Julia O Misiorek, Yaming Jiu, Hongbo Chen, Zhi Chen, Diana M Toivola, Fang Cheng*, John E Eriksson*,Vimentin suppresses inflammation and tumorigenesis in the mouse intestine, Frontiers in Cell and Developmental Biology 2022, doi: 10.3389/fcell.2022.862237 (IF= 6.684)
9. Weixian Zhang#, Jingxiong Lin, Peilin Shi, Dandan Su, Xiaoli Cheng, Wenkai Yi, Jian Yan, Hongbo Chen*, Fang Cheng*, Small extracellular vesicles derived from MSCs have immunomodulatory effects to enhance delivery of ASO-210 for psoriasis treatment, Frontiers in Cell and Developmental Biology 2022, doi: 10.3389/fcell.2022.842813 (IF= 6.684).
10. Chao He, Manqi Zhang, Lingling Liu, Yuhang Han, Zhanxue Xu, Yue Xiong, Fuxia Yan, Dandan Su, Hongbo Chen*, Yongjiang Zheng*, Fang Cheng*.Cellular membrane-based vesicles displaying a reconstructed B cell maturation antigen for multiple myeloma therapy by dual targeting APRIL and BAFF. Acta Biomater, 2022, doi: 10.1016/j.actbio.2022.02.028 (IF= 10.633)
11. Hsiang-i Tsai#, Yingyi Wu#, Xiaoyan Liu#, Zhanxue Xu, Longshan Liu, Yisheng Huang, Linglu Wang, Weixian Zhang, Huanxi Zhang, Dandan Su, Fahim Ullah Khan, Changxi Wang, John E. Eriksson, Bo Jia*, Fang Cheng*, Hongbo Chen*, Engineered small extracellular vesicles as a FGL1/PD-L1 dual-targeting delivery system for alleviating immune rejection, Advanced Science 2021, doi:10.1002/advs.202102634 (IF= 15.444)
12. Hsiang-i Tsai#, Yanping Wu#, Rui Huang#, Dandan Su, Yingyi Wu, Xiaoyan Liu, Linglu Wang, Zhanxue Xu, Fang Cheng*, Laiqiang Huang*, Hongbo Chen*， PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 and repressing rDNA transcription, Acta Pharmaceutica Sinica B 2021，https://doi.org/10.1016/j.apsb.2021.10.025 (IF= 11.413)
13. Hao Wang#, Dandan Su#, Rufan Huang, Fan Shu, Fang Cheng*, Gang Zheng*. Cellular nanovesicles with bioorthogonal targeting enhance photodynamic/photothermal therapy in psoriasis. Acta BioMaterialia. 2021, S1742-7061(21)00506-7. (IF= 10.633)
14. Sepideh Parvanian#, Hualian Zha#, Dandan Su, Lifang Xi, Yaming Jiu, Hongbo Chen, John. E. Eriksson, Fang Cheng*. Exosomal Vimentin from Adipocyte Progenitors Protects Fibroblasts against Osmotic Stress and Inhibits Apoptosis to Enhance Wound Healing.Int. J. Mol. Sci. 2021, 22(9), 4678; https://doi.org/10.3390/ijms22094678（IF=5.923）
15. Hsiang-i Tsai#, Xiaobin Zeng#, Longshan Liu#, Shengchang Xin, Yingyi Wu, Zhanxue Xu, Gan Liu, Zirong Bi, Dandan Su, Min Yang, Changxi Wang, Jing Zhao, John E. Eriksson, Wenbin Deng*, Fang Cheng*, Hongbo Chen*. NF45/NF90-mediated rDNA transcription provides a novel target for immunosuppressant development.EMBO Molecular Medicine, 2021（13）:e12834（IF=12.137）
16. Min Yang#, Zhanxue Xu#, Hailan Yan#, Hsiang-i Tsai, Dandan Su, Fuxia Yan, Qiumei Lu, Jianhua Feng, Weiwei Zeng, Lifang Xi, Hualian Zha, Yunzhi Ling, Chao He, Yingyi Wu, Xiaowei Xu, Gang Zheng, Gan Liu*, Hongbo Chen*, and Fang Cheng*. PD-L1 cellular nanovesicles carrying rapamycin inhibit alloimmune responses in transplantation. Biomaterials Science. 2021. 9(4):1246-1255. (IF= 6.843)
17. Kang Wang#, Zhengyang Zhang#, Tsai Hsiang-i#, Yanfang Liu, Ming Wang, Lian Song, Xiongfeng Cao, Zhanxue Xu, Hongbo Chen, Aihua Gong, Dongqing Wang*, Fang Cheng*, Haitao Zhu*. BCAT2 Regulates Ferroptotic Cell Death in Cancer Cells. Cell Death and Differentiation, 2020, 28(4):1222-1236 （IF=15.828)
18. Zhanxue Xu#, Hsiang-i Tsai#, Youmei Xiao, Yingyi Wu, Dandan Su, Min Yang, Hualian Zha, Fuxia Yan, Xiaoyan Liu, Fang Cheng*, Hongbo Chen*, Engineering PD-L1/CTLA-4 dual-targeting nanovesicles for immunosuppressive therapy in transplantation. ACS Nano. 2020, 14(7):7959-7969. （IF=15.881）
19. Dandan Su#, Hsiang-i Tsai#, Zhanxue Xu#, Fuxia Yan, Yingyi Wu, Youmei Xiao, Xiaoyan Liu, Yanping Wu, Sepideh Parvanian, Wangshu Zhu, John E. Eriksson, Dongqing Wang, Haitao Zhu*, Hongbo Chen*, Fang Cheng*. Exosomal PD-L1 functions as an immunosuppressant to promote wound healing, Journal of Extracellular Vesicles, 2019, 9(1): 1709262 (IF=25.841)
20. Lirong Zhang#, Hui Shi#, Hongbo Chen#, Aihua Gong, Yanfang Liu, Lian Song, Xuewen Xu, Tao You, Xin Fan, Dongqing Wang*, Fang Cheng* & Haitao Zhu* Dedifferentiation process driven by radiotherapy-induced HMGB1/TLR2/YAP/HIF-1α signaling enhances pancreatic cancer stemness. Cell Death & Disease, 10 (10)：1-16 (IF=9.685)
21. Wenyang Xu, Xue Zhang, Peiru Yang, Otto Långvik, Xiaoju Wang*, Yongchao Zhang, Fang Cheng, Monika Österberg, Stefan Willför, Chunlin Xu*. (2019) Surface engineered biomimetic inks based on UV cross-linkable wood biopolymers for 3D printing. ACS Applied Materials & Interfaces, 11 (13): 12389–12400 (IF= 10.383)
22. Xu W, Zhang B, Cheng F, Milonio P, Yue Z, Wang X*, Willfor S, Xu C*, Wallace G. (2019) On Low-Concentration Inks Formulated by Nanocellulose Assisted with Gelatin Methacrylate (GelMA) for 3D Printing toward Wound Healing Application. ACS Applied Materials & Interfaces. 11(9): 8838-8848. (IF= 10.383)
23. Xuelian Chen#, Fang Cheng#, Dongqing Wang*, Yanfang Liu, Lirong Zhang, Lian Song, Xiaojie Cai, Tao You, Xin Fan, Aihua Gong*, Haitao Zhu*. (2019) TLR2 and TLR4 exhibit distinct regulation of cancer cell stemness mediated by cell death-induced HMGB1. EBioMedicine. 2019, 40, 135-150. (IF= 11.1)
24. Yongchao Zhang, Singhi Wang, Wenyang Xu, Fang Cheng, Andrey Pranovich, Annika Smeds, Stefan Willför, Chunlin Xu. (2019) Valorization of lignin-carbohydrate complexes from hydrolysates of Norway spruce: Efficient separation, structural characterization, and antioxidant activity. ACS Sustainable Chem. Eng., 7 (1): 1447–1456. (IF=9.224)
25. Xu C*, Zhang B, Wang X, Cheng F*, Xu W, Molino P, Bacher M, Rosenau T, Willför S, Wallace G*. (2018) 3D printing of nanocellulose hydrogel scaffold with tuneable mechanical strength towards wound healing application. Journal of Materials Chemistry B, 6: 7066-7075. (IF=7.0)
26. Chen X, Zhang L, Jiang Y, Song L, Liu Y, Cheng F, Fan X, Cao X, Gong A, Wang D*, Zhu H*. (2018) Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis. Journal of experimental & clinical cancer research, 37: 77-91. (IF=11.161)
27. Mohammad I, Nousiainen K, Bhosale S, Starskaia I, Moulder R, Rokka A, Cheng F, Mohanasundaram P, Eriksson J, Goodlett D, Lähdesmäki H, Chen Z*. (2018) Quantitative proteomic characterization and comparison of T helper 17 and induced regulatory T cells. PLOS Biology, 16(5): e2004194. (IF=9. 593)
28. Sjöqvist M.#, Antfolk D.#, Cheng F., Isoniemi K., Duran C., Rivero-Muller A., Antila C., Niemi R., Landor S., Bouten C., Bayless K., Eriksson J.E. and Sahlgren C. (2017) Selective regulation of Notch ligands during angiogenesis is mediated by vimentin. PNAS, 114(23): E4574- E4581. (IF=11. 205)
29. Sahlgren C., Meinander A., Zhang H., Cheng F., Preis M., Xu C., Salminen T., Toivola D, Abankwa D., Rosling A, Karaman D. Salo-Ahen O., Österbacka R., Eriksson J., Willför S., Petre I., Peltonen J., Leino R., Johnson M., Rosenholm J., and Sandler N. (2017) Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems. Advanced Healthcare Materials, 6(21) DOI: 10.1002/adhm.201700258. (IF=11.092)
30. Jiu Y., Peranen J., Schaible N., Cheng F., Eriksson J., Krishnan R., and Lappalainen P. (2017) Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA. J Cell Sci, 130: 892-902 (IF=5. 285)
31. Cheng F., Shen Y., Mohanasundaram P., Lindström M., Ivaska J., Ny T., and Eriksson J.E. (2016) Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGFb-Slug signaling. PNAS 113(30):4320-4327 (IF= 11. 205)
32. Wang X.*, Cheng F.*, Liu J., Smått J., Gepperth D., Lastusaari M., Xu C. and Hupa L. (2016) Biocomposites of copper-containing mesoporous bioactive glass and nanofibrillated cellulose for chronic wound healing. Acta Biomater 46:286-298 (IF=10.633)
33. Liu J., Cheng F., Grénman H., Spoljaric S.,, Seppälä J., Eriksson J.E., Willför S., and Xu C. (2016) Development of nanocellulose scaffolds with tunable structures to support 3D cell culture. Carbohydrate Polymers, 148:259-271. (IF=10. 723)
34. Liu J., Chinga-Carrasco G., Cheng F., Xu W., Willför S., Syverud K. *and Xu C. * (2016) Hemicellulose-reinforced nanocellulose hydrogels for wound healing applications. Cellulose: 4320-4327 (IF=5. 7)
35. Shen Y., Cheng F., Sharma M., Merkulova Y., Raithatha S.A., Parkinson L.G., Zhao H., Westendorf K., Bohunek L., Bozin T., Hsu I., Ang L.S., Williams S.J., Bleackley R.C., Eriksson J.E., Seidman M.A., McManus B.M., and Granville D.J. (2016). Granzyme B Deficiency Protects against Angiotensin II-Induced Cardiac Fibrosis. American Journal of Pathology 186(1):87-100. (IF=6. 0)
36. Virtakoivu R., Mai A., Mattila E., De Franceschi N., Imanishi S. Y., Corthals G., Kaukonen R., Saari M., Cheng F., Torvaldson E., Kosma V. M., Mannermaa A., Muharram G., Gilles C., Eriksson J., Soini Y., Lorens J. B., and Ivaska J. (2015) Vimentin-ERK signaling uncouples Slug gene regulatory function. Cancer Res. 75(11):2349-2362 (IF= 12. 701)
37. Björk J.K. #, Åkerfelt M#., Joutsen J., Puustinen M.C., Cheng F., Sistonen L., Nees M. (2015). Heat shock factor 2 is a suppressor of prostate cancer invasion. Oncogene 35: 1770–1784 (IF= 9. 867)
38. Jiu Y., Lehtimäki J., Tojkander S., Cheng F., Jäälinoja H., Liu X., Varjosalo M., Eriksson J., Lappalainen P. (2015). Bidirectional interplay between vimentin intermediate filaments and contractile actin stress fibers. Cell Reports 11: 1511–1518 (IF= 9. 995)
39. Seltmann K., Cheng F., Wiche G., Eriksson J. E., and Magin T. M. (2015) Keratins stabilize hemidesmosomes through regulation of beta4-Integrin turnover. J Invest Dermatol. 135:1609-1620 (IF= 8.551)
40. Cheng F. #, Pekkonen P. #, Laurinavicius S., Sugiyama N., Henderson S., Gunther T., Rantanen V., Kaivanto E., Aavikko M., Sarek G., Hautaniemi S., Biberfeld P., Aaltonen L., Grundhoff A., Boshoff C., Alitalo K., Lehti K., and Ojala P.M. (2011). KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition. Cell Host Microbe 10, 577-590. (IF= 30.3)
41. Cheng F., Weidner-Glunde M., Varjosalo M., Rainio E. M., Lehtonen A., Schulz T. F., Koskinen P. J., Taipale J., and Ojala P. M. (2009). KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. PloS Pathogens 5, e1000324. (IF= 7.464)
42. Varjosalo M#., Bjorklund M#., Cheng F., Syvanen H., Kivioja T., Kilpinen S., Sun Z., Kallioniemi O., Stunnenberg H. G., He W. W., Ojala P., and Taipale J. (2008). Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell 133, 537-548. (IF =66.85)