Pathogenic wound infections remain a major global health challenge. When skin tissue is wounded, some colonizing pathogenic bacteria secrete large amounts of hyaluronidase (HAase) to degrade the extracellular matrix (ECM), enabling their diffusion and proliferation. Current clinical techniques for detecting infection rely on basic visual cues or analysis of wound fluids, enabling only reactive treatment once severe signs manifest. Herein, we present the use of a closed-loop patch (CLP) for advanced wound management. The patch contains a bio-inspired sensor based on an engineered hyaluronic acid (HA) hydrogel that detects HAase secreted by invading pathogens. This detection triggers a quantifiable change in the capacitance of the interdigital electrode and achieving in-time detection of () infection in a murine wound model before obvious visual signs appear. In response, the release of titanium hydride (TiH) nanodots from hydrogel decomposition can eradicate pathogens under ultrasound (US) irradiation. Concurrently, the product, HA fragments further promoted cell migration and angiogenesis to significantly improve wound healing by ∼14.6-fold rates in 12 days. Overall, the CLP provides a sensory act-treat effect according to the wound status, which facilitate the closed-loop integration of monitoring and rehabilitation. This strategy may provide additional possibilities for the design of future wound management systems.
链接：https://www.sciencedirect.com/science/article/pii/S1748013224002561?via%3Dihub