Abstract: Metal, as an active participant in life activities, has always been at the forefront of research. Recent studies have revealed the crucial role of metal ions in activating the anti-tumor immune response; thus, developing nanomedicines based on bioactive metals for enhanced cancer immunotherapy has become an emerging and thriving field. This review aims to provide the latest advances and comprehensively discusses the biological effects and applications of these bioactive metal-based nanomedicines in boosting anti-tumor immunity, mainly including typical main-group metals (e.g., Na, K, Ca, Mg, and Al), transition metals (e.g., Fe, Cu, Mn, and Zn), and rare-earth metals (e.g., Ce, La, Gd, and Eu). Finally, we present our perspective on this rapidly developing field to address the potential future challenges.
链接：https://www.sciencedirect.com/science/article/pii/S0010854524003151?via%3Dihub