Construction of Porous Organic Polymer Coordinated Palladium Nanoparticle Catalysts for Catalytic Synthesis of Coumarin Derivatives 

Coumarins are the backbone of numerous drugs for rare diseases, and efficient multiphase catalytic synthesis of coumarins remains a great challenge. In this paper, a dicarboxyl porous organic polymer coordinated palladium catalyst, Pd-PV-MS, was synthesized by a free radical copolymerization method. The catalyst was characterized and used in the electrophilic addition reaction of phenols and alkynoates for the synthesis of coumarin derivatives. The results demonstrated that, in most cases, high product yields could be obtained with only a small amount of the catalyst (below 2.4 mol%). The catalyst is applicable to a broad range of substrates with high catalytic performance. Moreover, the catalyst can be reused for several times without loss of catalytic activity.

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