联系邮箱：yuqs@mail.buct.edu.cn

教育背景

2008.09-2014.06 中国科学院化学研究所，理学博士（高分子化学与物理专业）

2004.09-2008.06 北京化工大学材料学院，工学学士 （生物功能材料专业）

工作经历

2017.07 至今      北京化工大学生命学院，副教授

2014.07-2017.06 北京化工大学生命学院，博士后

学术兼职

《Biomaterials》、《ACS Applied Materials & Interfaces》、《Theranostics》等多本学术期刊审稿人，国家自然科学基金函评专家，教育部学位论文评审专家。

主要研究领域

1.新型抗肿瘤纳米药物设计与制备；

2.纳米药物纳米特性与体内递送过程相关性；

3.基于肿瘤微环境调控的肿瘤免疫治疗；

4.抗肿瘤纳米药物转化医学研究。

获奖及荣誉

2019年 北京化工大学青年英才“百人计划”

科研项目

2016年 国家自然科学基金青年项目；

2018年 国家自然科学基金面上项目；

2018年 教育部ZBYY联合基金；

2020年 国家自然科学基金面上项目。

代表性文章

1.Li, Y.; Jiang, Y.; Zheng, Z.; Du, N.; Guan, S.; Guo, W.; Tang, X.; Cui, J.; Zhang, L.; Liu, K.; Yu, Q.*; Gan, Z.*; Co-delivery of precisely prescribed multi-prodrug combination by an engineered nanocarrier enables efficient individualized cancer chemotherapy, Advanced Materials, 2022, 34: 2110490.

2.Zhu, X.; Li, L.; Tang, J.; Yang, C.; Yu, H.; Liu, K.; Zheng, Z.; Gu, X.*; Yu, Q.*; Xu, F.; Gan, Z.; Cascade-responsive nano-assembly for efficient photothermal-chemo synergistic inhibition of tumor metastasis by targeting cancer stem cells, Biomaterials, 2022, 280: 121305

3.Yu, Y.; Xiang, K.; Xu, M.; Li, Y.; Cui, J.; Zhang, L.; Tang, X.; Zhu, X.; Qian, L.; Zhang, M.; Yang, Y.; Yu, Q.*; Shen, Y.; Gan, Z., Prodrug Nanomedicine Inhibits Chemotherapy-Induced Proliferative Burst by Altering the Deleterious Intercellular Communication. ACS Nano 2021, 15 (1), 781-796.

4.Shi, R.; Zhang, J.; Niu, K.; Li, W.; Jiang, N.; Li, J.; Yu, Q.*; Wu, C.*, Electrospun artificial periosteum loaded with DFO contributes to osteogenesis via the TGF-β1/Smad2 pathway. Biomaterials Science 2021, 9, 2090-2102.

5.Xu, X.; Liu, K.; Jiao, B.; Luo, K.; Ren, J.; Zhang, G.*; Yu, Q.*; Gan, Z*., Mucoadhesive nanoparticles based on ROS activated gambogic acid prodrug for safe and efficient intravesical instillation chemotherapy of bladder cancer. Journal of Controlled Release 2020, 324, 493-504.

6.Qin, M.; Cao, Z.; Wen, J.; Yu, Q.; Liu, C.; Wang, F.; Zhang, J.; Yang, F.; Li, Y.; Fishbein, G.; Yan, S.; Xu, B.; Hou, Y.; Ning, Z.; Nie, K.; Jiang, N.; Liu, Z.; Wu, J.; Yu, Y.; Li, H.; Zheng, H.; Li, J.; Jin, W.; Pang, S.; Wang, S.; Chen, J.*; Gan, Z.*; He, Z.*; Lu, Y.*, An Antioxidant Enzyme Therapeutic for COVID-19. Advanced Materials 2020, 32 (43).

7.Luo, K.; Guo, W.; Yu, Y.; Xu, S.; Zhou, M.; Xiang, K.; Niu, K.; Zhu, X.; Zhu, G.; An, Z.; Yu, Q.*; Gan, Z.*, Reduction-sensitive platinum (IV)-prodrug nano-sensitizer with an ultra-high drug loading for efficient chemo-radiotherapy of Pt-resistant cervical cancer in vivo. Journal of Controlled Release 2020, 326, 25-37.

8.Guo, D.; Li, L.; Zhu, X.; Heeney, M.; Li, J.; Dong, L.; Yu, Q.; Gan, Z.; Gu, X.*; Tan, L.*, Naphthalene diimide based near-infrared luminogens with aggregation-induced emission characteristics for biological imaging and high mobility ambipolar transistors. Science China-Chemistry 2020, 63 (9), 1198-1207.

9.Zhou, Q.; Shao, S.; Wang, J.; Xu, C.; Xiang, J.; Piao, Y.; Zhou, Z.; Yu, Q.; Tang, J.; Liu, X.; Gan, Z.; Mo, R.; Gu, Z.; Shen, Y., Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy. Nature Nanotechnology 2019, 14 (8), 799-809.

10.Zhang, Y.; Fang, Q.; Niu, K.; Gan, Z.; Yu, Q.*; Gu, T.*, Time-dependently slow-released multiple-drug eluting external sheath for efficient long-term inhibition of saphenous vein graft failure. Journal of Controlled Release 2019, 293, 172-182.

11.Zhou, D.-H.; Zhang, G.; Yu, Q.-S.*; Gan, Z.-H.*, Folic Acid Modified Polymeric Micelles for Intravesical Instilled Chemotherapy. Chinese Journal of Polymer Science 2018, 36 (4), 479-487.

12.Zhang, X.; He, F.; Xiang, K.; Zhang, J.; Xu, M.; Long, P.; Su, H.; Gan, Z.*; Yu, Q.*, CD44-Targeted Facile Enzymatic Activatable Chitosan Nanoparticles for Efficient Antitumor Therapy and Reversal of Multidrug Resistance. Biomacromolecules 2018, 19 (3), 883-895.

13.Zhang, J.; Tang, H.; Shen, Y.; Yu, Q.*; Gan, Z.*, Shell-Sheddable Poly(N-2-hydroxypropyl methacrylamide) Polymeric Micelles for Dual-Sensitive Release of Doxorubicin. Macromolecular Rapid Communications 2018, 39 (20).

14.Tang, H.; Zhang, J.; Tang, J.; Shen, Y.; Guo, W.; Zhou, M.; Wang, R.; Jiang, N.; Gan, Z.*; Yu, Q.*, Tumor Specific and Renal Excretable Star-like Triblock Polymer-Doxorubicin Conjugates for Safe and Efficient Anticancer Therapy. Biomacromolecules 2018, 19 (7), 2849-2862.

15.Tang, H.; Tang, J.; Shen, Y.; Guo, W.-X.; Zhou, M.; Wang, R.-H.; Jiang, N.; Gan, Z.-H.*; Yu, Q.-S.*, Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties. Chinese Journal of Polymer Science 2018, 36 (11), 1225-1238.

16.Yan, X.; Yu, Q.*; Guo, L.; Guo, W.; Guan, S.; Tang, H.; Lin, S.; Gan, Z.*, Positively Charged Combinatory Drug Delivery Systems against Multi-Drug-Resistant Breast Cancer: Beyond the Drug Combination. ACS Applied Materials & Interfaces 2017, 9 (8), 6804-6815.

17.Shen, T.; Xu, X.; Guo, L.; Tang, H.; Diao, T.; Gan, Z.; Zhang, G.*; Yu, Q.*, Efficient Tumor Accumulation, Penetration and Tumor Growth Inhibition Achieved by Polymer Therapeutics: The Effect of Polymer Architectures. Biomacromolecules 2017, 18 (1), 217-230.

18.Shen, T.; Guan, S.; Gan, Z.; Zhang, G.*; Yu, Q.*, Polymeric Micelles with Uniform Surface Properties and Tunable Size and Charge: Positive Charges Improve Tumor Accumulation. Biomacromolecules 2016, 17 (5), 1801-1810.

19.Du, N.; Guo, W.; Yu, Q.*; Guan, S.; Guo, L.; Shen, T.; Tang, H.; Gan, Z.*, Poly(D,L-lactic acid)-block-poly(N-(2-hydroxypropyl) methacrylamide) nanoparticles for overcoming accelerated blood clearance and achieving efficient anti-tumor therapy. Polymer Chemistry 2016, 7 (36), 5719-5729.

20.Yu, Q.; Zhang, J.; Zhang, G.; Gan, Z., Synthesis and Functions of Well-defined Polymer-drug Conjugates as Efficient Nanocarriers for Intravesical Chemotherapy of Bladder Cancer. Macromolecular Bioscience 2015, 15 (4), 509-520.

21.Yu, Q.#; Wei, Z.#; Shi, J.; Guan, S.; Du, N.; Shen, T.; Tang, H.; Jia, B.; Wang, F.; Gan, Z., Polymer-Doxorubicin Conjugate Micelles Based on Poly(ethylene glycol) and Poly(N-(2-hydroxypropyl) methacrylamide): Effect of Negative Charge and Molecular Weight on Biodistribution and Blood Clearance. Biomacromolecules 2015, 16 (9), 2645-2655.

22.Yu, Q.#; Dong, C.#; Zhang, J.; Shi, J.; Jia, B.; Wang, F.; Gan, Z., Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution. Polymer Chemistry 2014, 5 (19), 5617-5627.

23.Wei, Z.; Yu, Q.; Gan, Z., Thermosensitive block copolymers PEG-b-PBEMAGG containing functional pendant amino groups. Macromolecular Research 2012, 20 (3), 313-318.