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顾月清 二级教授    

顾月清教授,中国药科大学工学院院长,二级教授,江苏省“333”第一层次培养对象,江苏省青蓝工程”学科带头人。多个国家级学术团体的常务理事、理事。《激光生物学报》、《生物技术通讯》、国际影像学杂志AJNMMI、《中国药科大学学报》等编委。先后江苏省科技进步奖教育部自然科学奖中国产学研创新奖等。近年来一直致力于肿瘤早期诊断探针及靶向前药的研究,将分子影像技术、生物信息学等融合到药物研究各领域,开发了多种活细胞、活体检测分子探针,并自行研制相关仪器,结合各种抗癌药物及纳米载体研究靶向抗肿瘤前药。近几年,主持多项国家级重点项目,包括973 课题、国家重大科研仪器研制项目、国家自然科学基金重大研发计划、国自然重点项目、重大国际合作基金、重大研究计划、海外及港澳合作研究项目等。已申请多项国家发明专利、国际专利( PCT ),体外HPV宫颈癌筛查诊断试剂、手术导航荧光探针等正进行临床转化。5年在国际权威杂志发表了SCI收录论文100多篇,包括Angew. Chem. Int. Ed , ACS NanoCancer ResearchAdvanced Material, Biomaterials,TheranoticsJ. Controlled Release, Advanced Science等高水平论文。


近年代表论文:

  1. Yi Ma, Zhaohui Wang, Yuxuan Ma, Zhihao Han, Min Zhang, Haiyan Chen* and Yueqing Gu* A Telomerase Responsive DNA-icosahedron for Precise Delivery of Platinum-nanodrug to Cisplatin-resistance Cancer, Angewandte chemie, 2018, DIO: 10.1002/anie.201801195. IF= 11.994

  2. Ma Y, Wang ZH, Zhang M, Han ZH, Chen D, Zhu QY, Gao WD, Qian ZY* and Gu YQ*. A TelomeraseSpecific DoxorubicinReleasing Molecular Beacon for Cancer Theranostics. Angewandte Chemie International Edition, 2016, 55(10): 3304-3308. IF= 11.994

  3. Liu Y, Wang S, Ma Y, Gu Y*, Chen XY*, Huang P*, et al. Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Living Subjects [J]. Advanced Materials, 2017, 29(17).  IF=18.96

  4. Cui S, Yin D, Chen Y, Gu Y*, et al. In vivo targeted deep-tissue photodynamic therapy based on near-infrared light triggered upconversion nanoconstruct[J]. ACS nano, 2012, 7(1): 676-688. IF=12.0

  5. Cao J, Cui S, Li S, Gu Y*, et al. Targeted Cancer Therapy with a 2-Deoxyglucose–Based Adriamycin Complex[J]. Cancer research, 2013, 73(4): 1362-1373.IF=9.2

  6. Gao W, Wang Z, Lv L, Gu Y*, et al. Photodynamic Therapy Induced Enhancement of Tumor Vasculature Permeability Using an Upconversion Nanoconstruct for Improved Intratumoral Nanoparticle Delivery in Deep Tissues[J]. Theranostics, 2016, 6(8): 1131. IF=8.8

  7. Deng D, Chen Y, Cao J, Gu Y*, et al. High-quality CuInS2/ZnS quantum dots for in vitro and in vivo bioimaging[J]. Chemistry of Materials, 2012, 24(15): 3029-3037. IF=8.2

  8. Wang ZH, Li SW, Zhang M, Ma Y, Liu YX, Gao WD, Zhang JQ and Gu YQ*. LaserTriggered Small Interfering RNA Releasing Gold Nanoshells against Heat Shock Protein for Sensitized Photothermal Therapy. Advanced Science, 2017, 4(2). IF= 9.034

  9. Ma Y, Ai GH, Zhang CY, Zhao ML, Dong X, Han ZH, Wang ZH, Zhang M, Liu YX, Li SW and Gu YQ*. Novel linear peptides with high affinity to αvβ3 integrin for precise tumor identification. Theranostics, 2017, 7(6): 1511. IF= 8.712

  10. Zhou QM, Ma Y, Wang ZH, Wang K, Liu RN, Han ZH, Zhang M, Li SW and Gu YQ*. Optimized Ultrasound Conditions for Enhanced Sensitivity of Molecular Beacons in the Detection of MDR1 mRNA in Living Cells. Analytical chemistry, 2016, 88(5): 2808-2816. IF= 6.32