代表性论文

1. Chuanbin Shen, Daniel T Mackeigan, Aron A Shoara, Runjia Xu, Preeti Bhoria, Danielle Karakas, Wenjing Ma, Eric Cerenzia, ZiYan Chen, Brock Hoard, Lisha Lin, Xi Lei, Guangheng Zhu, Pingguo Chen, Philip E Johnson, Heyu Ni. Dual roles of fucoidan-GPIbα interaction in thrombosis and hemostasis: implications for drug development targeting GPIbα. Journal of Thrombosis and Haemostasis 2023, 21(5):1274-1288. (IF= 10.40)

2. Meiquan Li, Xiaopeng Tang, Zhiyi Liao, Chuanbin Shen, Ruomei Cheng, Mingqian Fang, Gan Wang, Ya Li, Shuzhen Tang, Li Xie, Zhiye Zhang, Peter Muiruri Kamau, James Mwangi, Qiumin Lu, Yaxiong Li, Yuming Wang, Daniel Thomas Mackeigan, Eric G. Cerenzia, Heyu Ni, Ren Lai. Hypoxia and low temperature up-regulate transferrin to induce hypercoagulability at high altitude. Blood 2022, 140 (19), 2063-2075. (IF= 25.476)

3. Zhiye Zhang, Chuanbin Shen(co-first author), Mingqian Fang, Yajun Han, Chengbo Long, Weihui Liu, Min Yang, Ming Liu, Dengdeng Zhang, Qiqi Cao, Xue Chen, Yaqun Fang, Qiumin Lu, Zongliu Hou, Yaxiong Li, Zhenze Liu, Xi Lei, Heyu Ni, Ren Lai. Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke. Cellular and Molecular Life Sciences 2022, 79(5):240. (IF= 9.207)

4. Chuanbin Shen, Ming Liu, Daniel Mackeigan, Ziyan Chen, Pingguo Chen, Danielle Karakas, June Li, Peter Norris, Jiayao Li, Yanling Deng, Chengbo Long, Ren Lai, Heyu Ni. Viper venoms drive the macrophages and hepatocytes to sequester and clear platelets: Novel mechanism and therapeutic strategy for venom-induced thrombocytopenia. Archives of Toxicology 2021, 95(11): 3589-3599. (IF= 6.168)

5. Ming Liu, Gan Wang, Runjia Xu, Chuanbin Shen, Heyu Ni, Ren Lai. Soy isoflavones inhibit both GPIb-IX signaling and αIIbβ3 outside-in signaling via 14-3-3ζ in platelet. Molecules 2021, 26(16): 4911. (IF= 4.927)

6. Chuanbin Shen, Ming Liu, Runjia Xu, Gan Wang, June Li, Pingguo Chen, Wenjing Ma, James Mwangi, Qiumin Lu, Zilei Duan, Zhiye Zhang, Fatima Dahmani, Daniel Mackeigan, Heyu Ni, Ren Lai. The 14-3-3ζ-c-Src-integrin-β3 complex is vital for platelet activation. Blood 2020, 136(8): 974-988. (IF= 23.629)

7. Chuanbin Shen, Ming Liu, Huiwen Tian, Jiameng Li, Runjia Xu, James Mwangi, Qiumin Lu, Xue Hao, Ren Lai. Conformation-specific blockade of αIIbβ3 by a non-RGD peptide to inhibit platelet activation without causing significant bleeding and thrombocytopenia. Thrombosis and Haemostasis 2020, 120(10): 1432-1441. (IF= 6.681)

8. Chengbo Long, Ming Liu, Huiwen Tian, Ya Li, Feilong Wu, James Mwangi, Qiumin Lu, Abd El-Aziz Tarek Mohamed, Ren Lai, Chuanbin Shen (Corresponding author). Potential role of platelet-activating c-type lectin-like proteins in viper envenomation induced thrombotic microangiopathy symptom. Toxins 2020, 12(12):749. (IF= 5.075)

9. Xiaopeng Tang, Mingqian Fang, Ruomei Cheng, Zhiye Zhang, Yuming Wang, Chuanbin Shen (co-first author), Yajun Han, Qiumin Lu, Yingrong Du, Yingying Liu, Zhaohui Sun, Liping Zhu, James Mwangi, Min Xue, Chengbo Long, Ren Lai. Iron-deficiency and estrogen are associated with ischemic stroke by up-regulating transferrin to induce hypercoagulability. Circulation Research 2020, 127(5): 651-663. (IF= 17.367)

10. Huiwen Tian, Ming Liu, Jiameng Li, Runjia Xu, Chengbo Long, Hao Li, James Mwangi, Qiumin Lu, Ren Lai, Chuanbin Shen (Corresponding author). Snake c-type lectins potentially contribute to the prey immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri venoms. Toxins 2020, 12(2): 105. (IF= 5.075)

11. Runjia Xu, Shuohan Fei, Linyan Chen, Gan Wang, Ming Liu, Wensheng Zhang, Xiuwen Yan, Ren Lai, Chuanbin Shen (Corresponding author). 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels. Chinese Journal of Natural Medicines 2019, 17(6): 413-423. (IF= 3.887)

12. Lin Jin, Xiaomin Guo, Chuanbin Shen (co-first author), Xue Hao, Peng Sun, Pengpeng Li, Tao Xu, Chunmiao Hu, Ombati Rose, Hongning Zhou, Mingdong Yang, Cheng-Feng Qin, Jingya Guo, Hua Peng, Mingzhao Zhu, Gong Cheng, Xiaopeng Qi, Ren Lai. Salivary factor LTRIN from Aedes Aegypti facilitates the transmission of zika virus by interfering with the lymphotoxin-β receptor. Nature Immunology 2018, 19(4):342-353. (IF= 31.250)

13. Xiaoqin He, Chuanbin Shen (co-first author), Qiumin Lu, Jiong Li, Yuquan Wei, Li He, Ruizhen Bai, Jie Zheng, Ning Luan, Zhiye Zhang, Mingqiang Rong, Ren Lai. Prokineticin 2 plays a pivotal role in psoriasis. EBioMedicine 2016, 13: 248-261. (IF= 11.205)

14. Zhiye Zhang, Ping Meng, Yajun Han, Chuanbin Shen, Bowen Li, Md Abdul Hakim, Xuguang Zhang, Qiumin Lu, Mingqiang Rong, Ren Lai. Mitochondrial DNA-LL-37 complex promotes atherosclerosis by escaping from autophagic recognition. Immunity 2015, 43(6): 1137-1147. (IF= 24.082)

15. Zhiye Zhang, Lan Gao, Chuanbin Shen, Mingqiang Rong, Xiuwen Yan, Ren Lai. A potent anti-thrombosis peptide (vasotab TY) from horsefly salivary glands. The international journal of biochemistry & cell biology 2014, 54: 83-88. (IF= 5.652)

学术报告及摘要

1. 申传斌，血小板膜糖蛋白Ib（GPIb）阻断剂在防治血栓性心脑血管疾病中的研究。2023年全国心血管药理学术会议，特邀报告。

2. 申传斌，靶向血小板膜糖蛋白Ib（GPIb）防治血栓性心脑血管疾病的研究。山东药理学会暨山东省药学会药理专业委员会2023年学术年会，口头汇报。

3. Chuanbin Shen, Daniel Mackeigan, Guangheng Zhu, Miguel Neves, Wenjing Ma, Eric Cerenzia, Heyu Ni. Snake Venom Botrocetin Induces GPIb-Independent Platelet Aggregation. Blood 2021, 138: 4203.（美国血液学年会摘要）

4. Chuanbin Shen. Two Birds One Stone: 14-3-3ζ blocker inhibits both GPIb signaling and αIIbβ3 outside-in signaling in platelets. International Conference on Cardiovascular Sciences 2021, oral talk.

授权发明专利

1. 十八烷基化修饰的多肽在制备血小板聚集的药物中的应用，专利号：202010805686.7

2. 3,4,7‑三羟基异黄酮或3‑甲氧基大豆素在制备抑制血小板聚集和血栓药物中的应用，专利号：201710070868.2

3. 十八烷基化修饰的R18-7AA多肽及其衍生多肽的应用，专利号：202010805688.6