Zahra Nozhat（Ph.D.）

Education:

PhD Degree: Shahied Beheshti University of Medical Sciences, Tehran, Iran.

January 2013-July 2018

I studied for PhD of Molecular Medicine in Cell and Molecular Biology. Title of thesis was:  Assessment of metformin effects on genes and proteins expression involved in PI3K/AKT/FoxO1 pathway, an AMPK-independent pathway, in anaplastic and medullary thyroid carcinoma cell lines. My total score for the thesis was 19.98 (from 0-20), and my total score for MS degree was 19.58 (from 0-20).

MS Degree: University of Mohaghegh Ardabili, Ardabil, Iran. September 2008-September 2010.I studied for Master of Science in Cell and Molecular Biology. Title of thesis was:  Preparation and characterization of polypeptide containing nanoparticles and their biological effects. My total score for the thesis was 19.87 (from 0-20), and my total score for MS degree was 17.61 (from 0-20).

Bachelor Degree: University of Shahrekord, Shahrekord, Iran. September 2003- Jun 2007. I studied for bachelor in Genetic. My total score for bachelor degree was 16.27 (from 0-20).

Publications(partial):

[1] Nozhat Zahra,Heydarzadeh Shabnam,Memariani Zahra,Ahmadi Amirhossein. Chemoprotective and chemosensitizing effects of apigenin on cancer therapy[J]. Cancer Cell International,2021,21(1):

[2] Maryam Zarkesh,Mina Shahriari-Khalaji,Zahra Nozhat. Application of Bacterial Nanocellulose in Cancer Drug Delivery: A Review[J]. Current Pharmaceutical Design,2021,27(34):

[3] Nozhat Zahra,Zarkesh Maryam , Baldini Enke,Mohammadi-Yeganeh Samira , Azizi Feridoun,Hedayati Mehdi, “Antineoplastic Activity of an Old Natural Antidiabetic Biguanide on the Human Thyroid Carcinoma Cell Line”, Anti-Cancer Agents in Medicinal Chemistry 2021; 21() . https://doi.org/10.2174/1871520621666210118093532

[4] Nozhat Zahra ,Khalaji S. Mina ,Hedayati Mehdi ,Kia K. Sima, “Different Methods for Cell Viability and Proliferation Assay: Essential Tools in Pharmaceutical Studies”, Anti-Cancer Agents in Medicinal Chemistry 2021; 21() . https://doi.org/10.2174/1871520621999201230202614

[5] Maryam Zarkesh,Azita Zadeh-Vakili,Mahdi Akbarzadeh,Zahra Nozhat,S. Ahmad Fanaei,Mehdi Hedayati,Fereidoun Azizi. BRAF V600E mutation and microRNAs are helpful in distinguishing papillary thyroid malignant lesions: Tissues and fine needle aspiration cytology cases[J]. Life Sciences,2019,223:

[6] Zahra Nozhat,Mehdi Hedayati,Hoda Pourhassan. Signaling pathways in medullary thyroid carcinoma: therapeutic implications[J]. Int. J. Endo. Oncol.,2016,3(4):

Research Projects:

1.Assessment of metformin effects on genes and proteins expression involved in PI3K/AKT/FoxO1 pathway, an AMPK-independent pathway, in anaplastic and medullary thyroid carcinoma cell lines

2.Assessment of the effect of PI3k/AKT/mTOR and Wnt/beta catenin pathway inhibitors coadministration on different thyroid cancer cell lines

3. The Assessment of Thyroid Cancer Cell Lines Metabolome by NMR Method

4. Metabolomics Study of Thyroid Cancer Cell Lines by GC/MS

5. Development and Production of an ELISA Kit for Human Insulin Assay

6. Development and Production of an ELISA Kit for Human Anti Thyroid Peroxidase (TPO) Assay