研究方向集中在生物纳米功能材料（纳米酶）的理性设计及其在生物医学领域的应用。已在Nature Communications、Chemical Society Reviews、Analytical Chemistry、Theranostics等杂志发表SCI论文20余篇（10篇一作/共同一作），以第一作者出版英文专著一本，申请专利1项，并受邀担任ACS Symposium Series eBook编辑。所发表论文累计被引2000余次，其中两篇第一作者论文被选为ESI高被引论文。参加多次国内外学术会议，并作英文口头报告或墙报展示。
科研经历
2014.09——至今 纳米酶的理性设计及其在生物医学领域的应用
Ø 以生物分析领域广泛应用的过氧化物酶为目标，选用结构和性能易于调节的钙钛矿氧化物作为研究对象，将实验与理论计算相结合，系统研究了金属氧化物纳米材料的电子结构对其过氧化物酶活性的影响，阐明了金属氧化物纳米酶的催化机理，首次获得了指导纳米酶设计的描述符；并将优化的镍基钙钛矿纳米酶成功地应用到生物分析领域，实现了对葡萄糖和肌氨酸的灵敏检测。
Ø 成功建立了基于纳米酶的生物分析新方法。通过构建纳米酶传感器阵列，实现了对非特异性靶向物质如生物硫醇，蛋白质，肿瘤细胞的检测，并实现了对这些非特异性靶向物质的选择性区分；利用C3N4基纳米酶成功构建了比率型荧光检测平台，提高了纳米酶传感器输出信号的稳定性和可靠性。
Ø 利用纳米酶有效调控活性氧物种（ROS）水平，发展了抗炎症和抗肿瘤治疗新策略。
期刊论文（#, 共同第一作者）
1. Xiaoyu Wang, # Xuejiao Gao, # Li Qin, Changda Wang, Li Song, Yong-Ning Zhou, Guoyin Zhu, Wen Cao, Shichao Lin, Liqi Zhou, Kang Wang, Huigang Zhang, Zhong Jin, Peng Wang, Xingfa Gao, Hui Wei,* “eg occupancy as an effective descriptor for the catalytic activity of perovskite oxide-based peroxidase mimics”, Nature Communications, 2019, 10, 704.
2. Xiaoyu Wang, Li Qin, Hui Wei,* “Fluorescent Graphitic Carbon Nitride-Based Nanozymes with Peroxidase-like Activities for Ratiometric Biosensing” Analytical Chemistry, 2019, 91, 10648-10656.
3. Xiaoyu Wang,# Li Qin,# Min Zhou, Zhangping Lou, Hui Wei,* “Nanozyme Sensor Arrays for Detecting Versatile Analytes from Small Molecules to Proteins and Cells” Analytical Chemistry, 2018, 90, 11696-11702.
4. Xiaoyu Wang, Wen Cao, Li Qin, Tingsheng Lin, Wei Chen, Shichao Lin, Jia Yao, Xiaozhi Zhao, Min Zhou, Cheng Hang, Hui Wei,* “Boosting the Peroxidase-Like Activity of Nanostructured Nickel by Inducing Its 3+ Oxidation State in LaNiO3 Perovskite and Its Application for Biomedical Assays” Theranostics, 2017, 7, 2277-2286.
5. Xiaoyu Wang, Xiaoqian Jiang, Hui Wei,* “Phosphates-responsive 2D-Metal−Organic-Framework-Nanozyme for Colorimetric Detection of Alkaline Phosphatase” Journal of Materials Chemistry B, 2020, 8, 6905-6911.
6. Xiaoqian Jiang,# Xiaoyu Wang,# Anqi Lin, Hui Wei,* “In situ exsolution of noble metal nanoparticles on perovskites as enhanced peroxidase mimics for bioanalysis” Analytical Chemistry, 2021, 93, 5954-5962.
7. Xiaoyu Wang, Shaojun Dong,* Hui Wei,* “Recent advances on nanozyme-based electrochemical biosensors” Electroanalysis, in press.
8. Xiaoyu Wang, Yihui Hu, Hui Wei,* “Nanozymes in bionanotechnology: from sensing to therapeutics and beyond” Inorganic Chemistry Frontiers, 2016, 3, 41-60.
9. Li Qin,# Xiaoyu Wang,# Yufeng Liu, Hui Wei,* “2D-Metal–Organic-Framework-Nanozyme Sensor Arrays for Probing Phosphates and Their Enzymatic Hydrolysis” Analytical Chemistry, 2018, 90, 9983-9989.
10. Hanjun Cheng,# Xiaoyu Wang,# Hui Wei,* “Ratiometric electrochemical sensor for effective and reliable detection of ascorbic acid in living brains” Analytical Chemistry, 2015, 87, 8889-8895.
11. Xiaoyu Wang, Hui Wei,* “Peroxidase-like nanozyme sensing arrays for versatile analytes” Journal of Nanoparticle Research, 2020, 22, 22.
12. Jiangjiexing Wu, Xiaoyu Wang, Quan Wang,# Zhangping Lou,# Sirong Li,# Yunyao Zhu,# Li Qin, Hui Wei,* “Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)” Chemical Society Reviews, 2019, 48, 1004-1079.
13. Rui Zhong, Xiaoyu Wang, Qianqian Tao, Jianhua Zhang, Chu-Hong Lin,* Hui Wei,* Yige Zhou,* “From Ensemble Electrochemistry to Nano-Impact Electrochemistry: Altered Reaction Selectivity” Angewandte Chemie International Edition, 2022, in revision.
15. Yufeng Liu, Xiaoyu Wang, Quan Wang, Yihong Zhang, Quanyi Liu, Shujie Liu, Sirong Li, Yan Du, Hui Wei,* “Structurally engineered light-responsive nanozymes for enhanced substrate specificity” Analytical Chemistry, 2021, 93, 15150.
16. Min Zhou, Xiaoyu Wang, Shichao Lin, Yufeng Liu, Junshu Lin, Bo Jiang, Xiaozhi Zhao and Hui Wei,* “Combining photothermal therapy-induced immunogenic cell death and hypoxia relief-benefited M1-phenotype macrophage polarization for cancer immunotherapy” Advanced Therapeutics, 2021, 4, 2000191.
17. Yufeng Liu, Xiaoyu Wang, Hui Wei,* “Light-responsive nanozymes for biosensing” Analyst, 2020, 145, 4388-4397.
18. Chong-Bo Ma, Yaping Xu, Lixin Wu, Quan Wang, Jia-Jia Zheng, Guoxi Ren, Xiaoyu Wang, Xingfa Gao, Ming Zhou,* Ming Wang,* Hui Wei,* “Guided Synthesis of a Mo/Zn Dual Single-Atom Nanozyme with Synergistic Effect and Peroxidase-like Activity” Angewandte Chemie International Edition, 2022, in press.
19. Shichao Lin,# Yuan Cheng,# He Zhang,# Xiaoyu Wang, Yuye Zhang, Yuanjian Zhang, Leiying Miao, Xiaozhi Zhao, Hui Wei,* “Copper tannic acid coordination nanosheet: a potent nanozyme for scavenging ROS from cigarette smoke” Small, 2020, 16, 1902123.
20. Yunyao Zhu,# Jiangjiexing Wu,# Lijun Han, Xiaoyu Wang, Hongchao Guo, Hui Wei,* “Nanozyme sensor arrays based on heteroatom-doped graphene for detecting pesticides” Analytical Chemistry, 2020, 92, 7444-7452.
21. Junshu Lin, Quan Wang, Xiaoyu Wang, Yunyao Zhu, Xi Zhou, Hui Wei,* “Gold Alloy-Based Nanozyme Sensor Arrays for Biothiols Detection” Analyst, 2020, 145, 3916-3921.
22. Yufeng Liu, Min Zhou, Wen Cao, Xiaoyu Wang, Quan Wang, Sirong Li, Hui Wei,* “Light-Responsive Metal-Organic-Framework as an Oxidase Mimic for Cellular Glutathione Detection” Analytical Chemistry, 2019, 91, 8170-8175.
23. Shichao Lin, Yihong Zhang, Wen Cao, Xiaoyu Wang, Li Qin, Min Zhou, Hui Wei,* “Nucleobase-mediated synthesis of nitrogen-doped carbon nanozymes as efficient peroxidase mimics” Dalton Transactions, 2019, 48, 1993-1999.
24. Shuangshuang Ren, Yi Zhou, Kai Zhang, Xuanwen Xu, Jie Yang, Xiaoyu Wang, Leiying Miao,* Hui Wei,* Yan Xu,* “Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering”, Bioactive Materials, 2022, 7, 242.
25. Wen Cao#, Junshu Lin#, Faheem Muhammad#, Quan Wang, Xiaoyu Wang, Zhangping Lou, and Hui Wei,* “Porous ruthenium selenide nanoparticle as a peroxidase mimic for glucose bioassay” Journal of Analysis and Testing, 2019, 2019, 3, 253-259.
26. Jia Yao, Yuan Cheng, Min Zhou, Sheng Zhao, Shichao Lin, Xiaoyu Wang, Jiangjiexing Wu, Sirong Li, Hui Wei,* “ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation” Chemical Science, 2018, 9, 2927-2933.
27. Yuming Dai, Shaochun Tang, Xiaoyu Wang, Xiang Huang, Chao Zhu, Zusheng Hang, Xiangkang Meng,* “MnO2–Au Composite Electrodes for Supercapacitors” Chemistry Letters, 2013, 43, 122-124.
专著
1. Xiaoyu Wang, Wenjing Guo, Yihui Hu, Jiangjiexing Wu, Hui Wei,* Nanozymes: next wave of artificial enzymes, 2016, Springer.
2. Xiaoyu Wang,* Hui Wei.* “Rational Design of Peroxidase Nanozymes” in Nanozymes: Advances and Applications, Edited by Sundaram Gunasekaran, 2021, CRC press/Tylor & Francis. Invited chapter, in press.
3. Hanjun Cheng, Xiaoyu Wang, Hui Wei,* “Artificial Enzymes: The Next Wave (Chapter 16)” in “Encyclopedia of Physical Organic Chemistry”, Edited by Zerong Wang, 2017, John Wiley and Sons.
获得专利
1. 基于过渡金属氧化物及其衍生物的高活性纳米酶及其获得方法和应用【已授权】
魏辉、王小宇、秦溧
申请日期：2019.01.23 专利号：201910065792.3
会议
1. Rational design of transition metal oxides-based peroxidase mimics
Xiaoyu Wang, Xuejiao J. Gao, Xingfa Gao, Hui Wei，Poster展示
NJU-Wiley Joint Conference on Microstructured Materials and Advanced Applications, 南京，2019.11.29 – 12.1
2. Design principles for perovskite oxide-based peroxidase mimics
Xiaoyu Wang, Xuejiao J. Gao, Xingfa Gao, Hui Wei，15分钟英文口头报告
The Seventeenth International Symposium on Electroanalytical Chemistry (17th ISEAC), 长春，2019.8.23 – 8.25
3. eg occupancy as an effective descriptor for the catalytic activity of perovskite oxide-based peroxidase mimics
Xiaoyu Wang, Xuejiao J. Gao, Xingfa Gao, Hui Wei，15分钟英文口头报告，获得学生旅费奖
The 6th Nano Today Conference，里斯本，2019.6.16 - 6.20
4. Universal nanozyme sensor arrays for detecting analytes from small molecules to proteins and cells
Xiaoyu Wang, Hui Wei，Poster展示
第13届中美华人纳米论坛（The 13th Sino-US Forum on Nanoscale Science and Technology），成都，2018.6.29 - 7.3
5. Nanozymes for Bioanalytical and Biomedical Applications
Xiaoyu Wang, Hui Wei，Poster展示
The Sixteenth International Symposium on Electroanalytical Chemistry (16th ISEAC)，长春，2017.8.17 - 8.20
6. Ratiometric electrochemical sensor for effective and reliable detection of ascorbic acid in living brains
Xiaoyu Wang, Hanjun Cheng, Hui Wei，15分钟英文口头报告
第六届纳米生物国际会议（NANOBIO CHINA 2016），南京，2016.10.17 - 10.19
科研项目
1. 国家自然科学基金青年项目，22104055，eg电子占有率指导设计基于尖晶石氧化物的高效类过氧化物酶及其生物分析应用，2022-01至2024-12，30万元，在研，主持。
2. 中国博士后科学基金特别资助（站前），2019TQ0144，可用于ROS调控的纳米酶：理性设计及其生物治疗应用，2019-07至2021-06，18万元，在研，主持。
3. 中国博士后科学基金面上项目，2019M661786，MXene基抗氧化纳米酶的构建及其生物治疗应用研究，2019-09至2021-07，8万元，在研，主持。
4. 国家重点研发计划“变革性技术关键科学问题”重点专项，2019YFA0709202，纳米界面高效酶催化及传感体系，2020-06至2025-05，2176万元，在研，参加。