In recent years, there has been a notable surge in the prominence of enantioenriched sulfur(VI) compounds within the chemical science. However, the synthesis of these enantioenriched sulfur(VI) compounds has posed significant challenges, necessitating the exploration of diverse synthetic methods. This review aims to provide an in-depth analysis of the latest advancements in the synthesis of sulfoximines, sulfonimidate esters, sulfonimidamides, and sulfonimidoyl halides. This fantastic research field of chemistry will usher in a period of rapid development in the near future.

We have developed a diversity-oriented, substrate-controlled, chemoselective synthetic method for a variety of structurally diverse 1-sulfonylquinazoline-2,4(1H,3H)-diones and 2-sulfonamidobenzonitriles. This substrate-controlled synthesis is accomplished through the condensation reaction of 2-(sulfonamido)benzamides with or without an N-methyl group on the amides. The reactions are fulfilled within half an hour at room temperature with solid triphosgene as a convenient condensing agent and pyridine as an acid acceptor. This protocol features easily available starting materials, mild reaction conditions, easy experimental operation, and moderate to excellent yields of products.