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成果及论文

2024

17."Application of monoamine oxidase in organic synthesis" Shao, Y.; Gao, Y.-D.; He, Z.-L.; Yang, L.-C. Chem Catal. 202410.1016/j.checat.2024.101068.

16."Application of Imine Reductase in Bioactive Chiral Amine Synthesis" Wang, Z.; Gao, G.-S.; Gao, Y.-D.; Yang, L.-C. Org. Process Res. Dev. 202410.1021/acs.oprd.4c00147.

15."Harnessing transaminases to construct azacyclic non-canonical amino acids" Chao, T.-H.; Wu, X.; Fu, Y.; Yang, L.; Renata, H. Nat. Synth. 202410.1038/s44160-024-00514.

     


14. “Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients" Cui,Y.; Gao, Y.; Yang, L.Green Synth. catal. 202410.1016/j.gresc.2024.03.003.  


13. "Biocatalytic Hydrogen-Borrowing Cascade in Organic Synthesis" Liu, Z.-X.; Gao, Y.-D., Yang, L.-C.* JACS Au, 2024, 4, 877-892.

Figure 1


Before IMM

12. “Recent Progress and Developments in Chemoenzymatic and Biocatalytic Dynamic Kinetic ResolutionYang, L.-C.; Deng, H.; Renata, H. Org. Process Res. Dev. 2022, 26, 1925-1943. (Invited Review) 


11. “Diastereoselective Synthesis of β-Branched α-Amino Acids via Biocatalytic Dynamic Kinetic Resolution,” Li, F.;# Yang, L.-C.;# Zhang, J.; Chen, J. S.; Renata, H.* Angew. Chem., Int. Ed. 2021, 60, 17680-17685. (Co-first author; Featured in Synfacts)

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10. “Ligand Coordination/Dissociation-Induced Divergent Allylic Alkylations Using Alkynes," Huang, Y.; Ma, C.; Liu, S.; Yang, L.-C.; Lan, Y.;* Zhao, Y.* Chem. 20217, 812-826.


9. “Divergent Synthesis of Complex ent-Kauranes, ent-Atisanes and ent-Trachylobanes via a Hybrid Oxidative Approach,” Zhang, X.; King-Smith, E.; Dong, L.-B.; Yang, L.-C.; Rudolf, J. D.; Shen, B.; Renata, H.* Science2020369, 799-806.

C&EN’s 2021 Talented 12: Hans Renata


8. “Stereoselective Access to [5.5.0] and [4.4.1] Bicyclic Compounds through Pd-Catalysed Divergent Higher-Order Cycloadditions,” Yang L.-C.;# Wang, Y.-N.;# Liu, R.; Luo, Y.; Ng, X. Q.; Yang, B.; Rong, Z.-Q.; Lan, Y.;* Shao, Z.;* Zhao, Y.* Nat. Chem. 2020, 12, 860-868.


7. “Dynamic Kinetic Asymmetric Amination of Alcohols Assisted by Microwave: Stereo-convergent Access to Tetralin- and Indane-Derived Chiral Amines," Rong, Z.-Q.; Yu, Z.; Weng, C.; Yang, L.-C.; Lu, S.; Lan, Y.;* Zhao, Y.* ACS Catal. 202010, 9464-9475.

Figure 1


6. “Pd-Titanium Relay Catalysis Enables Switch of Alkoxide-π-Allyl to Dienolate Reactivity for Spiro-Heterocycle Synthesis," Yang, L.-C.; Tan, Z. Y.; Rong, Z.-Q.; Liu, R.; Wang, Y.-N.; Zhao, Y.* Angew. Chem. Int. Ed. 2018, 57, 7860-7864. (Featured in Synfacts)

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5. “Pd-Catalyzed Enantioselective [6+4] Cycloaddition of Vinyl Oxetanes with Azadienes to Access Ten-Membered Heterocycles,” Wang, Y.-N.;# Yang L.-C.;# Rong, Z.-Q.; Liu, T.-L.; Liu, R.; Zhao, Y.* Angew. Chem., Int. Ed. 2018, 57, 1596-1600. (Co-first author; featured in Synfacts)

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4. “Nine-membered Benzofuran-Fused Heterocycles: Enantioselective Synthesis by Pd-Catalysis and Rearrangement via Transannular Bond Formation” Rong, Z.-Q.;# Yang, L.-C.;# Liu, S.; Yu, Z.; Wang, Y.-N.; Tan, Z. Y.; Huang, R.-Z.; Lan, Y.;* Zhao, Y.* J. Am. Chem. Soc. 2017, 139, 15304-15307. (Co-first author; featured in Synfacts)

Figure 1


3. “Construction of Nine-Membered Heterocycles through Palladium-Catalyzed Formal [5+4] Cycloaddition,” Yang, L.-C.;# Rong, Z.-Q.;# Wang, Y.-N.; Tan, Z. Y.; Wang, M.; Zhao, Y.* Angew. Chem. Int. Ed. 2017, 56, 2927-2931. (Featured in Synfacts; ESI highly cited paper)

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2. “Acid-Assisted Ru-Catalyzed Enantioselective Amination of 1,2-Diols through Borrowing Hydrogen,” Yang, L.-C.; Wang, Y.-N.; Zhang, Y.;* Zhao, Y.* ACS Catal., 2017, 7, 93-97. (Featured in Synfacts)

Figure 1


1. “Practical, Highly Stereoselective Allyl- and Crotylsilylation of Aldehydes Catalyzed by Readily Available Cinchona Alkaloid Amide," Huang, Y.; Yang, L.; Shao, P.; Zhao, Y.* Chem. Sci. 20134, 3275-3281.

Graphical abstract: Practical, highly stereoselective allyl- and crotylsilylation of aldehydes catalyzed by readily available Cinchona alkaloid amide