【Title】Multifunctional nanoreactors with nutrient consumption and ROS generation capabilities for antibacterial and skin repair

【Abstract】Bacterial wound infection has brought a serious threat to human health and caused huge economic losses. Attempts to develop biomaterials with excellent antibacterial effects are meaningful to promote wound healing. Herein, we reported a multifunctional nanoreactor with nutrient consumption and reactive oxygen species (ROS) generation capabilities for antibacterial and skin wound repair. The nanoreactor was constructed by the encapsulation of glucose oxidase (GOx) into the Cu²⁺-doped zeolite-based imidazole framework (ZIF-8) through a one-pot synthesis method. The nanoreactor not only consumes the nutrients of bacteria by the GOx-driven oxidation reaction, but also generates highly toxic hydroxyl radicals (·OH) to kill bacteria via a Cu⁺-mediated Fenton-like reaction. Moreover, Zn²⁺ released from the nanoreactor is also capable of synergistic antibacterial activity. In addition to mediating Fenton-like reaction, Cu²⁺ also promotes angiogenesis to accelerate wound healing. Thus, the multifunctional nanoreactor has the ability to cut off the nutrient supply and starve the bacteria, produce ROS to kill bacteria, and promote angiogenesis to accelerate wound healing, so it is promising for the treatment of wound infection.

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