张小朋，博士研究生，北京化工大学材料科学与工程学院。2016年9月加入本实验室，主要研究方向为高分子可溶性微针药物控释的研究。截止目前，已发表学术论文19篇，其中第一作者（含共同第一作者）4篇；申请中国发明专利1项。

• Bo Zhi Chen, Wen Xuan Li, Yun Hao Feng, Xiao Peng Zhang, Jie Jiao, Zhuo Lin Li, Vahideh Nosrati-Siahmazgi, Mohammad-Ali Shahbazi, Xin Dong Guo, Functional insulin aspart/insulin degludec-based microneedles for promoting postprandial glycemic control. Acta Biomaterialia, 2023, 171, 350-360.
• Bo Zhi Chen, Meng Chan He, Xiao Peng Zhang, Wen Min Fei , Yong Cui, Xin Dong Guo, A novel method for fabrication of coated microneedles with homogeneous and controllable drug dosage for transdermal drug delivery. Drug Delivery and Translational Research, 2022, 12, 2730-2739.
• Wen Xuan Li, Xiao Peng Zhang, Bo Zhi Chen, Wen Min Fei, Yong Cui, Can Yang Zhang, Xin Dong Guo, An update on microneedle based systems for diabetes. Drug Delivery and Translational Research, 2022, 12, 2275–2286.
• Xiao Peng Zhang, Yu Ting He, Wen Xuan Li, Bo Zhi Chen, Can Yang Zhang, Yong Cui, Xin Dong Guo, An update on biomaterials as microneedle matrixes for biomedical applications. Journal of Materials Chemistry B, 2022, 10: 6059.
• Xiao Peng Zhang, Bao Li Zhang, Bo Zhi Chen, Ze Qiang Zhao, Wen Min Fei, Yong Cui, Xin Dong Guo, Dissolving microneedle rollers for rapid transdermal drug delivery. Drug Delivery and Translational Research, 2022, 12(2): 459-471.
• Yun Hao Feng, Xiao Peng Zhang, Liu Fu Hu, Bo Zhi Chen, Xin Dong Guo, Mesoscopic Simulation for the Effect of Cross-Linking Reactions on the Drug Diffusion Properties in Microneedles. Journal of Chemical Information and Modeling, 2021, 61(8): 4000-4010.
• Yun Hao Feng, Xiao Peng Zhang, Wen Xuan Li, Xin Dong Guo, Stability and diffusion properties of insulin in dissolvable microneedles: A multiscale simulation study. Langmuir, 2021, 37(30): 9244-9252.
• Xiao Peng Zhang, Bei Bei Wang, Liu Fu Hu, Wen Min Fei, Yong Cui, Xin Dong Guo, Safety evaluation of 3-month effects of microneedle patches prepared from hyaluronic acid in mice. Biochemical Engineering Journal, 2021, 176: 108157.
• Ze Qiang Zhao, Bo Zhi Chen, Xiao Peng Zhang, Hui Zheng, Xin Dong Guo, An update on the routes for the delivery of donepezil. Molecular Pharmaceutics, 2021, 18(7): 2482-2494.
• Xiao Peng Zhang, Bei Bei Wang, Wen Xuan Li, Wen Min Fei, Yong Cui, Xin Dong Guo, In vivo safety assessment, biodistribution and toxicology of polyvinyl alcohol microneedles with 160-day uninterruptedly applications in mice. European Journal of Pharmaceutics and Biopharmaceutics, 2021, 160: 1-8.
• Bao Li Zhang, Xiao Peng Zhang, Bo Zhi Chen, Wen Min Fei, Yong Cui, Xin Dong Guo, Microneedle-assisted technology for minimally invasive medical sensing. Microchemical Journal, 2021, 162: 105830.
• Yu Ying Hao, Yuan Yang, Qiu Yu Li, Xiao Peng Zhang, Chang Bing Shen, Chao Zhang, Yong Cui, Xin Dong Guo, Effect of polymer microneedle pre-treatment on drug distributions in the skin in vivo. Journal of Drug Targeting, 2020, 28(7-8): 811-817.
• Bo Zhi Chen, Li Qin Zhang, Yi Yun Xia, Xiao Peng Zhang, Xin Dong Guo, A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control. Science Advances, 2020, 6(28): eaba7260.
• Dan Dan Zhu, Xiao Peng Zhang, Bao Li Zhang, Yu Ying Hao, Xin Dong Guo, Safety Assessment of Microneedle Technology for Transdermal Drug Delivery: A Review. Advanced Therapeutics, 2020, 3(8): 2000033.
• Yun Hao Feng, Xiao Peng Zhang, Yu Ying Hao, Gui Yao Ren, Xin Dong Guo, Simulation study of the pH sensitive directed self-assembly of rheins for sustained drug release hydrogel. Colloids and Surfaces B: Biointerfaces, 2020, 194: 111260.
• Yun Hao Feng, Xiao Peng Zhang, Jun You Li, Xin Dong Guo, How is a micelle formed from amphiphilic polymers in a dialysis process: Insight from mesoscopic studies. Chemical Physics Letters, 2020, 754: 137711.
• Li Qin Zhang, Xiao Peng Zhang, Yu Ying Hao, Bao Li Zhang, Xin Dong Guo, Codelivery of hydrophilic and hydrophobic drugs in a microneedle patch for the treatment of skin pigmentation. Journal of Industrial and Engineering Chemistry, 2020, 88(25): 241-250.
• Yun Hao Feng, Xiao Peng Zhang, Ze Qiang Zhao, Xin Dong Guo, Dissipative particle dynamics aided design of drug delivery systems: A review. Molecular Pharmaceutics, 2020, 17(6): 1778-1799.
• Jing Ling Liu, Yun Hao Feng, Xiao Peng Zhang, Dan Dan Zhu, Li Qin Zhang, Xin Dong Guo, Experimental and theoretical studies of drug-polymer interactions to control the drug distributions in dissolving microneedles. Journal of Industrial and Engineering Chemistry, 2020, 84: 280-289.
• Ling Liang, Yang Chen, Bao Li Zhang, Xiao Peng Zhang, Jing Ling Liu, Chang Bing Shen, Yong Cui, Xin Dong Guo, Optimization of dip-coating methods for the fabrication of coated microneedles for drug delivery. Journal of Drug Delivery Science and Technology, 2020, 55: 101464.
• Bo Zhi Chen, Jing Ling Liu, Qiu Yu Li, Ze Nan Wang, Xiao Peng Zhang, Chang Bing Shen, Yong Cui, Xin Dong Guo, Safety evaluation of solid polymer microneedles in human volunteers at different application sites. ACS Applied Bio Material, 2019, 2(12): 5616-5625.
• Dan Dan Zhu, Xiao Peng Zhang, Chang Bing Shen, Yong Cui, Xin Dong Guo, The maximum possible amount of drug in rapidly separating microneedles. Drug Delivery and Translational Research, 2019, 9(6): 1133-1142.
• Dan Dan Zhu, Xiaoli Wang, Xiao Peng Zhang, Jing Jing Ma, Deling Kong, Mingming Zhang, Xin Dong Guo, Chun Wang, A Dissolvable Microneedle Formulation of B. Pertussis Subunit Vaccine: Translational Development and Immunological Evaluation in Mice. ACS Applied Bio Materials, 2019, 2(11): 5053-5061.
• Dan Dan Zhu, Xiao Peng Zhang, Hong Li Yu, Rui Xuan Liu, Chang Bing Shen, Wei Fen Zhang, Yong Cui, Xin Dong Guo, Kinetic stability studies of HBV vaccine in a microneedle patch. International Journal of Pharmaceutics, 2019, 567: 118489.
• Bo Zhi Chen, Mohammad Ashfaq, Dan Dan Zhu, Xiao Peng Zhang, Xin Dong Guo, Controlled delivery of insulin using rapidly separating microneedles fabricated from genipin-crosslinked gelatin. Macromolecular Rapid Communications, 2018, 39(20): 1800075.
• Jia Nan Zhang, Bo Zhi Chen, Mohammad Ashfaq, Xiao Peng Zhang, Xin Dong Guo, Development of a BDDE-crosslinked hyaluronic acid based microneedles patch as a dermal fillers for anti-ageing treatment. Journal of Industrial and Engineering Chemistry, 2018, 65: 363-369.
• Bo Zhi Chen, Mohammad Ashfaq, Xiao Peng Zhang, Jia Nan Zhang, Xin Dong Guo, In vitro and in vivo assessment of polymer microneedles for controlled transdermal drug delivery. Journal of Drug Targeting, 2018, 26(8): 720-729.
• Qi Lei Wang, Xiao Peng Zhang, Bo Zhi Chen, Xin Dong Guo, Dissolvable layered microneedles with core-shell Structures for transdermal drug delivery. Materials Science and Engineering C, 2018, 83: 143-147.
• 郭新东, 张小朋, 一种可溶性滚轮微针装置, 2019. 中国实用新型专利, 201920815695.7, 申请日期: 2019.6.1.