张达，理学博士，中共党员，福建医科大学孟超肝胆医院，副研究员、支部副书记，硕士生导师。研究专注于肝癌靶向治疗，涉及肝癌微环境、肝癌细胞和肝癌突变基因这三个方面，主要工作包括开发药物靶向递送载体、肿瘤新抗原肽疫苗、肿瘤全细胞疫苗、靶向修饰NK细胞以及I型疱疹病毒等不同尺度的药物靶向递送和肿瘤免疫治疗研究。主持包括国家自然科学基金和福建省杰出青年基金在内的14项研究项目。在Journal for ImmunoTherapy of Cancer, Communications biology (Nature Journal), iScience (Cell press), Advanced Science (6篇), Angew. Chem. Int. Ed, Nano Letters, ACS Nano, Small (4篇), Theranostics（3篇）, Chemical Engineering Journal, Chemical Science, ACS Applied Materials&Interfaces (3篇)等主流期刊上，作为第一作者或共同通讯作者发表35篇研究性SCI论文，3篇ESI高引论文。拥有11项国家发明专利，成功转让了1项专利（120万），获得了福建省高层次人才C类、福建省杰出青年基金、福建省科学技术一等奖、福建医学科技二等奖、福建省优秀学术论文一等奖以及福州市医学科技突出贡献工作者等多项荣誉。担任第八届中国抗癌协会抗癌药物专业委员会委员、中国药理学会第八届肿瘤药理学专业委员会委员，参与3个企业合作项目。毕业8名，其中1名获得2022年福建省优秀学位论文奖。
二、获得荣誉
2022.07获得福建省杰出青年基金；
2021.10评为福建省高层次人才C类；
2022.12福建省科学技术奖一等奖（4/10）;
2021.08 福建医学科技奖二等奖（4/7）；
2022.12福建省自然科学优秀学术论文一等奖（1/7）；
2022.11. 福州市自然科学优秀学术论文一等奖（1/7）；
2023.12 福州市医学科技突出贡献工作者（4/5）；
2023年任中国抗癌协会抗癌药物专业委员会委员；
2023年任中国药理学会第八届肿瘤药理学专业委员会委员
2014.04年福州市十佳创新能手
三、主持及参与科研项目：
1. 2019.01-2021.12，国家自然科学基金青年项目：智能核壳型金属有机配位聚合物用于磁共振引导的肿瘤近红外二区光热协同治疗，61805041，25万元，主持，结题；
2. 2023.08-2025.08，中国博士后科学基金第73批面上项目：小窝蛋白介导胞质递送增强类病毒硅新抗原纳米疫苗抗肿瘤免疫治疗，2023M730610，8万元，主持，在研；
3. 2022.08-2025.08，福建省自然科学基金杰青项目：新生抗原疫苗递送载体设计及其应用， 2022J06034，30万，主持，在研；
4. 2022.10-2025.10，福建省科技创新联合资金项目：新型放疗增敏纳米材料提高肿瘤放射治疗效应的研究（交叉学科项目）, 2021Y9216，200万，主持，在研；
5. 2022.06-2024.06，福州市科技创新创业人才培育计划项目：增强新抗原疫苗免疫应答的类病毒硅仿生递送载体的制备与生物医学应用，2022-R-005, 15万，主持，在研；
6. 2022.08-2024.08福建省卫健委中青年骨干项目：新生抗原疫苗胞质递送增强肝癌个性化免疫治疗，2021GGB020，5万，主持，在研；
7. 2020.11-2023.11，福建省自然科学基金面上项目：基于光敏配位聚合物调控肿瘤微环境增强肝癌光化学-免疫治疗研究(2020J011154)，7万元，主持，结题；
8. 2016.04-2019.04，福建省自然科学基金面上项目：还原性敏感光敏化DNA-AQ4N适配体用于靶向肝癌监测及光动力诱导乏氧性化疗联合治疗，2016J01174，4万元，主持，结题；
9. 2015.04-2018.03，福州市科技计划项目：半导体聚合物纳米胶束用于肝癌光声-核磁共振成像及光学协同治疗的研究(2015-S-143-11)，5万元，主持，结题；
10. 2014.07-2017.06，福州市卫生系统科技计划项目：Gd/Au杂化脂质体作为肝癌靶向的CT/MRI双模态影像及热疗探针的应用研究，2014-S-w25，4万元，主持，结题；
11. 2016.01-2019.12，国家自然科学基金面上项目： 肿瘤特异靶向的长循环多功能纳米胶束用于肝癌的光声成像及光热/光动力协同治疗研究，61575044，60万元，参与，结题；
12. 2016.01-2019.12，国家自然科学基金“促进海峡两岸科技合作联合基金”：光声/MRI/CT多模态成像监测原发性肝癌靶向微创治疗，U1505221，215万元，参与，结题；
13. 2018.01-2022.12，国家自然科学基金“国家重大科研仪器研制项目”基于波前整形的高光谱成像引导的肿瘤光热/光动力双模治疗手术系统，61727823，780万元，参与，结题；
14. 2020.01-2023.12, 国家自然科学基金重大研究计划“基于核酸适体的膀胱癌相关标志物发现和可视化分析”，91959102，80万，参与，结题；
四、发表SCI论文35篇：(共同通讯14篇，一作或共一作者21篇)
[1] Han Zhou#, Lei Wang#, Zhiwen Lin#, Chenwei Jiang, Xingte Chen, Kai Wang, Libin Liu, Lingdong Shao, Jianji Pan, Jinluan Li*, Da Zhang*, Junxin Wu*, Methylglyoxal from Gut Microbes Boosts Radiosensitivity and Radioimmunotherapy in Rectal Cancer by Triggering Endoplasmic Reticulum Stress and cGAS-STING Activation, Journal of immunoTherapy of Cancer, 2023, 11(11), e007840. (IF = 10.6, 一区)
[2] Lei Wang#, Han Zhou#, Qingjing Chen#, Zhiwen Lin, Chenwei Jiang, Xingte Chen, Mingdong Chen, Libin Liu, Lingdong Shao, Xiaolong Liu, Jianji Pan, Jingcheng Wu, Jibin Song, Junxin Wu*, Da Zhang* . STING Agonist-Loaded Nanoparticles Promotes Positive Regulation of Type I Interferon-Dependent Radio-Immunotherapy in Rectal Cancer, Advanced Science, 2023, 2307858. (IF: 15.1, 一区)
[3] Zhuang, Qiuyu#., Zhao, Binyu#., Lin, Zhiwen., Liang, Yuzhi., Zhao, Qingfu., Wang, Yunhao.,Liao Naishun, Tu Haibin, Zheng Youshi, Chen Hengkai, Zeng Yongyi, Zhang Da*, Liu, Xiaolong*.. Navoximod modulates local HSV-1 replication to reshape tumor immune microenvironment for enhanced immunotherapy via an injectable hydrogel. Communications Biology, 2023, 6(1), 621. (IF: 6.1, 生物学小类一区)
[4] Liang, Yuzhi#., Wang, Bing#., Chen, Qingjing#., Fu, Xingyue., Jiang, Chenwei., Lin, Zhiwen., Zhuang Qiuyu, Zeng, Yongyi*, Liu Xiaolong*, Zhang, Da*. Systemic delivery of glycosylated- PEG-masked oncolytic virus enhances targeting of antitumor immuno-virotherapy and modulates T and NK cell infiltration. Theranostics, 2023, 13(15), 5452. (IF: 12.4, 一区)
[5] Lin, Zhiwen#., Jiang, Chenwei#., Wang, Peiyuan#., Chen, Qingjing., Wang, Bing., Fu, Xinyue., Liang Yuzhi, Zhang, Da*, Zeng Yongyi* & Liu, Xiaolong*. Caveolin-mediated cytosolic delivery of spike nanoparticle enhances antitumor immunity of neoantigen vaccine for hepatocellular carcinoma. Theranostics, 2023, 13(12), 4166. (IF: 12.4, 一区)
[6] Zhang, Da*#., Jiang, Chenwei#., Zheng, Xiaoyuan#., Lin, Zhiwen#., Zhuang, Qiuyu., Xie, Huanzhang., Liang Yuzhi, Xu Yu, Cui Linsheng, Liu Xiaolong*, Zeng, Yongyi*. Normalization of Tumor Vessels by Lenvatinib‐Based Metallo‐Nanodrugs Alleviates Hypoxia and Enhances Calreticulin‐Mediated Immune Responses in Orthotopic HCC and Organoids. Small, 2023, 2207786. (IF: 13.3, 一区)
[7] Ming Wu*, Hao Li*, Cao Zhang*, Yingchao Wang*, Cuilin Zhang, Yuting Zhang, Aoxue Zhong, Da Zhang*, Xiaolong Liu*. Silk-Gel Powered Adenoviral Vector Enables Robust Genome Editing of PD-L1 to Augment Immunotherapy across Multiple Tumor Models. Advanced Science, 2023, 10(12), 2206399. (IF: 15.1, 一区)
[8] Qingfu Zhao#, Yunhao Wang#, Binyu Zhao#, Hengkai Chen, Zhixiong Cai, Youshi Zheng, Yongyi Zeng, Da Zhang*, and Xiaolong Liu* Neoantigen Immunotherapeutic-Gel Combined with TIM-3 Blockade Effectively Restrains Orthotopic Hepatocellular Carcinoma Progression. Nano Letters. 2022. 9;22(5):2048-2058. (IF: 11.189, 一区, TOP)
[9] Yunhao Wang#, Qingfu Zhao#, Binyu Zhao, Youshi Zheng, Qiuyu Zhuang, Naishun Liao, Peiyuan Wang, Zhixiong Cai, Da Zhang*, Yongyi Zeng*, Xiaolong Liu*. Remodeling Tumor-Associated Neutrophils to Enhance Dendritic Cell-Based HCC Neoantigen Nano-Vaccine Efficiency. Advanced Science. 2022, 2105631. (IF: 15.1, 一区)
[10]. Zhijin Fan, Cheng Jiang, Yichao Wang, Kaiyuan Wang, Jade Marsh, Da Zhang*, Xin Chen*, Liming Nie* Engineered Extracellular Vesicles as Intelligent Nanosystem for Next-Generation of Nanomedicine, Nanoscale Horiz, 2022,7, 682-714. (IF: 11.684, 一区)
[11] Da Zhang#, Tianhong Teng#, Qingfu Zhao#, Zhiwen Lin, Junrong Zhang, Xiaolong Liu, and Yongyi Zeng* Nanoparticles for Near-Infrared Light-Driven Singlet Oxygen and CO Gas Cogeneration for Pancreatic Adenocarcinoma Therapy, ACS Appl. Nano Mater. 2022, 5, 11, 16741–16752 (IF: 6.1, 二区)
[12] Da Zhang#, Youshi Zheng#, Ziguo Lin, Xiaolong Liu, Juan Li*, Huanghao Yang*, Weihong Tan. Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking for Enhanced Adoptive Immunotherapy in Solid Tumors. Angew Chem Int Ed Engl.2020.59,12022-12028. (IF: 16.823, 一区, TOP)
[13] Da Zhang#, Ziguo Lin#, Ming Wu#, Zhixiong Cai, Youshi Zheng, Lei He, Zhenli Li, Jie Zhou, Liqin Sun, Geng Chen, Yongyi Zeng, Juan Li, Jingfeng Liu*, Huanghao Yang*, Xiaolong Liu*.Cytosolic Delivery of Thiolated Neoantigen Nano-vaccine Combined with Immune Checkpoint Blockade to Boost Anti-cancer T Cell Immunity. Advanced Science. 2021. 8, 2003504. (IF: 15.1, 一区)
[14] Da Zhang#, Ziguo Lin#, Youshi Zheng, Jibin Song, Juan Li, Yongyi Zeng,* and Xiaolong Liu*. Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition. ACS Nano, 2020. 14, 8985-8999. (IF: 18.027, 一区)
[15] Chengyun Chen, Yuhong Tong, Youshi Zheng, Yingjun Shi, Zhaowei Chen, Juan Li, Xiaolong Liu, Da Zhang*, Huanghao Yang*. Cytosolic Delivery of Thiolated Mn-cGAMP Nanovaccine to Enhance the Antitumor Immune Responses. Small. 2021.2006970. (IF: 13.3, 一区)
[16] Xianglian Liao, Youshi Zheng, Ziguo Lin, Yi Shen, Huiyun Lin, Xiaolong Liu, Da Zhang*, Buhong Li*. Self-assembled metallo-supramolecular nanoflowers for NIR / acidic-triggered multidrug release, long-term tumor retention and NIR-II fluorescence imaging-guided photo-chemotherapy. Chemical Engineering Journal. 2020. 400, 125882. (IF: 16.8, 一区)
[17] Da Zhang, Youshi Zheng, Ziguo Lin, Shanyou Lan, Xiaolong Zhang, Aixian Zheng, Juan Li, Gang Liu, Huanghao Yang, Xiaolong Liu*, Jingfeng Liu*. Artificial Engineered Natural Killer Cells Combined with Antiheat Endurance as Powerful Strategy for Enhancing Photothermal- Immunotherapy Efficiency of Solid Tumors. Small. 2019. 15, 1970228. (IF: 13.3, 一区)
[18] Da Zhang# , Cuilin Zhang# , Shanyou Lan, Yanbing Huang, Jingfeng Liu, Juan Li*, Xiaolong Liu*, Huanghao Yang* Near-Infrared Light Activated Thermosensitive Ion Channel to Remotely Control Transgene System for Thrombolysis Therapy. Small. 2019. 15, 1901176. (IF: 13.3, 一区)
[19]. Da Zhang, Ming. Wu, Zhixiong Cai, Naishun Liao, Kun Ke, Hongzhi Liu, Ming Li, Gang Liu, Huanghao Yang, Xiaolong Liu* , Jingfeng Liu*. Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle-Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy. Advanced Science, 2018. 5, 1700648. (IF: 15.1, 一区)
[20]. Da Zhang, Aixian Zheng, Juan Li, Ming Wu, Zhixiong Cai, Lingjie Wu, Zuwu Wei, Huanghao Yang, Gang Liu, Xiaolong Liu* , Jingfeng Liu*. Tumor Microenvironment Activable Self-Assembled DNA Hybrids for pH and Redox Dual-Responsive Chemotherapy / PDT Treatment of Hepatocellular Carcinoma, Advanced Science, 2017. 4, 1600460. (IF: 15.1, 一区)
[21]. Da Zhang, Aixian Zheng, Juan Li, Ming Wu, Lingjie Wu, Zuwu Wei, Naishun Liao, Xiaolong Zhang, Zhixiong Cai, Huanghao Yang, Gang Liu, Xiaolong Liu* , Jingfeng Liu*.Smart Cu(II)-aptamer complexes based gold nanoplatform for tumor micro-environment triggered programmable intracellular prodrug release, photodynamic treatment and aggregation induced photothermal therapy of hepatocellular carcinoma. Theranostics, 2017, 7,164-179. (IF: 12.4, 一区)
[22]. Da Zhang, Zhixiong Cai, Naishun Liao, Shanyou Lan, Ming Wu, Haiyan Sun, Zuwu Wei,Juan Li*, Xiaolong Liu*.pH / hypoxia programmable triggered cancer photo-chemotherapy based on a semiconducting polymer dot hybridized mesoporous silica framework. Chemical science, 2018. 9, 7390-7399. (IF: 9.825, 一区)
[23]. Ming Wu#, Dongye Zheng#, Da Zhang#, Peiwen Yu, Lianli Peng, Feng Chen, Ziguo Lin,Zhixiong Cai, Jiong Li, Zuwu Wei, Xinyi Lin, Jingfeng Liu*, Xiaolong Liu*. Converting Immune Cold into Hot by Biosynthetic Functional Vesicles to Boost Systematic Antitumor Immunity. iScience, 2020. 23, 101341. (IF: 5, Cell press二区)
[24]. Da Zhang, Ming Wu., Yongyi Zeng, Lingjie Wu, Qingtang Wang, Xiao Han, Xiaolong Liu*, Jingfeng Liu*.Chlorin e6 conjugated poly (dopamine) nanospheres as PDT / PTT dual-modal therapeutic agents for enhanced cancer therapy, ACS applied materials & interfaces, 2015. 7, 8176- 8187. (IF: 10.383, 二区)
[25]. Da Zhang, Hao Xu, Xiaolong Zhang, Yubin Liu, Ming Wu, Juan Li, Huanghao Yang, Gang Liu, Xiaolong Liu*, Jingfeng Liu*, Zhen Yuan. Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy. ACS applied materials & interfaces, 2018. 10, 25203-25212. (IF: 10.383, 二区)
[26] Shanyou Lan, Ziguo Lin, Da Zhang*, Yongyi Zeng*, Xiaolong Liu. Photocatalysis Enhancement for Programmable Killing of Hepatocellular Carcinoma through Self-Compensation Mechanisms based on Black Phosphorus Quantum Dot hybridized Nanocatalysts, ACS applied materials & interfaces, 2019. 11, 9804-9813. (IF: 10.383, 二区)
[27] Yanlin Du#, Da Zhang#, Yiru Wang, Ming Wu, Cuilin Zhang, Youshi Zheng, Aixian Zheng*, Xiaolong Liu* . A highly stable multifunctional aptamer for enhancing antitumor immunity against hepatocellular carcinoma by blocking dual immune checkpoints Biomaterials Science. 2021. 9, 4159-4168. (IF: 7.590, 二区)
[28] Youshi. Zheng, Cuilin. Zhang, Zishen. Lai, Yongyi. Zeng, Juan. Li, Da. Zhang* and Xiaolong. Liu*, Redirecting natural killer cells to potentiate adoptive immunotherapy in solid tumors through
stabilized Y-type bispecifific aptamer. Nanoscale, 2021.13,11279. (IF: 8.307, 二区)
[29] Liao, Naishun#, Da Zhang#, Ming Wu, Huanghao Yang, Xiaolong Liu*, and Jibin Song*. Enhancing therapeutic effects and in vivo tracking of adipose tissue-derived mesenchymal stem cells for liver injury using bioorthogonal click chemistry. Nanoscale. 2021.13,1813-1822. (IF: 8.307, 二区)
[30] Tianhong Teng#, Ronggui Lin#, Ziguo Lin, Kun Ke, Xianchao Lin, Maoen Pan, Da Zhang*, Heguang Huang*, Photothermal augment stromal disrupting effects for enhanced Abraxane synergy chemotherapy in pancreatic cancer PDX mode. Biomaterials Science. 2020. 21, 8: 3278-3285. (IF: 7.590, 二区)