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孙宇鹏 助理研究员    

孙宇鹏:理学博士,福建医科大学孟超肝胆医院,副研究员,硕士生导师。主要从事单细胞原位成像、肿瘤免疫微环境演进的可视化、肿瘤免疫治疗等方面的研究工作。主持国家自然科学基金、福建省自然科学基金、福建省科技创新联合资金项目等多个国家/省部级项目,其中国家级3项、省部级2项、市人才项目1项、厅局级2项,科研经费总计200多万元。申请人在国际化学顶级期刊如ChemChemical ScienceACS Central ScienceJournal of the American Chemical SocietyAngewandte Chemie International Edition上发表学术论文20多篇,申请国家发明专利2项,荣获福建省高层次人才(B类)及闽都英才称号。

 

研究方向

单细胞原位成像、肿瘤免疫微环境演进的可视化、肿瘤免疫治疗

 

主持承担的科研项目:

1)国家自然科学基金委员会,青年科学基金项目,21904021,基于滚环扩增的肿瘤浸润CD8+T细胞免疫状态的可视化研究,2020.01-2022.1225.00万元,结题,主持;

2)国家自然科学基金委员会,面上项目,22274023,多功能仿生纳米载体构建及其协同增强肝癌免疫检查点阻断治疗研究,2023.01-2026.1254.00万元,在研,主持;

3)福建省科技厅,自然科学基金项目(面上项目),2020J011153,基于流式细胞术和滚环扩增的miRNA高通量检测方法研究,2020.11-2023.117.00万元,结题,主持;

4)福建省科技厅,科技创新联合资金项目,2020Y9045,基于单细胞原位成像和逻辑编码技术的CD8+T细胞免疫状态的原位可视化研究,2021.08-2024.0815.00万元,在研,主持;

5)福建省卫健委,中青年科研重大项目,2021ZQNZD013,近红外二区光学成像介导的肝癌活体肿瘤微环境调控,2022.07-2026.06300.00万元,在研,参与;

6福州市科技厅,科技创新创业人才培育计划项目,2021-R-096,基于miRNA表达谱的肝癌早期预警模型构建及其临床应用研究,2021/06-2023/0630万元,在研,主持。


 

代表性论文:

1.     Sun Yupeng; Liu Yan; Li Rui; Zhang Cuilin; Wu Ming; Zhang Xiaolong; Xu Haipo; Zeng Rui; Zeng Yongyi*; Xiaolong Liu*; Direct Visualization of Immune Status for Tumor-Infiltrating Lymphocytes by Rolling Circle Amplification, Journal of Biophotonics, 2024, 17(2), e202300374.

2.     Ding Lei; Zhang Xiaolong; Yu Peiwen; Peng Fang; Sun Yupeng; Wu Yanni; Luo Zijin; Li Hongsheng; Zeng Yongyi; Wu Ming*; Liu Xiaolong*; Genetically engineered nanovesicles mobilize synergistic antitumor immunity by ADAR1 silence and PDL1 blockade, Molecular Therapy, 2023, 31: 2489-2506.

3.     Yupeng Sun, Ruijie Deng, Xiaojun Ren, Kaixiang Zhang, and Jinghong Li, 2D Gelatin Methacrylate Hydrogels with Tunable Stiffness for Investigating Cell Behaviors, ACS Applied Bio Materials, 2019, 2, 570–576.

4.     Yupeng Sun; Ruijie Deng; Kaixiang Zhang; Xiaojun Ren; Ling Zhang; Jinghong Li*, Single-cell study of extracellular matrix effect on cell growth by in situ imaging of gene expression, Chemical Science, 2017, 8 (12): 8019-8024.

5.     Yupeng Sun; Kaixiang Zhang; Ruijie Deng; Xiaojun Ren; Can Wu;Jinghong Li*, Tunable stiffness of graphene oxide/polyacrylamide composite scaffolds regulates cytoskeleton assembly, Chemical Science, 2018, 9 (31) : 6516-6522.

6.     Ruijie Deng; Kaixiang Zhang; Lida Wang; Xiaojun Ren; Yupeng Sun; Jinghong Li*, DNA-Sequence-Encoded Rolling Circle Amplicon for Single-Cell RNA Imaging, Chem, 2018, 4 (6), 1373-1386.

7.     Xiaojun Ren; Ruijie Deng; Kaixiang Zhang; Yupeng Sun; Xucong Teng; Jinghong Li*, SpliceRCA: in situ single-cell analysis of mRNA splicing variants, ACS central science, 2018, 4 (6), 680-687.

8.     Kaixiang Zhang, Ruijie Deng, Xucong Teng, Yue Li, Yupeng Sun, Xiaojun Ren, and Jinghong Li, Direct Visualization of Single-Nucleotide Variation in mtDNA using a CRISPR/Cas9-Mediated Proximity Ligation Assay (CasPLA), Journal of the American Chemical Society, 2018, 140, 11293–11301.