吴名,理学博士,福建医科大学孟超肝胆医院,研究员。针对肝癌精准诊疗的瓶颈问题,开展以新型生物材料为基础的基础与转化医学研究,旨在为肝癌防治提供重要科技支撑。相关成果在EMBO Molecular Medicine, Advanced Science, Molecular Therapy, Nano-Micro Letters,Angewandte Chemie,ACS Nano等一流期刊发表SCI论文60余篇,其中第一或通讯作者(含并列)37篇,影响因子20以上2篇,影响因子10以上论文11篇,授权发明专利11项;荣获福建省青年拔尖人才(2018年),福建省高层次人才(2021年),福州市第一届闽都英才,英国物理学会“China Top Cited Author Award” ,福建省科技进步一等奖,福建省自然科学优秀学术论文二等奖等科研奖励和荣誉称号;兼任福州大学和武汉工程大学硕士生导师,中国抗癌协会抗癌药物专业委员会委员,中国药理学会肿瘤药理学专业委员会委员等。
个人研究方向:
肿瘤分子影像、抗肿瘤纳米药物、肿瘤免疫治疗
获得荣誉称号及奖励:
1. China Top Cited Author Award(1/1),英国物理学会,2018年
2. 福建省科技进步一等奖(7/10),福建省人民政府,2022年
3. 福建省医学科技二等奖(3/7),福建省医学会,2020年
4. 福建省自然科学优秀学术论文二等奖(1/1),福建省科协、福建省科技厅、福建省教育厅,2018年
5. 福建省自然科学优秀学术论文三等奖(1/2),福建省科协、福建省科技厅、福建省教育厅,2022年
主持承担的科研项目:
6. 国家自然科学基金青年基金,81601538,肿瘤信号分子触发化学发光/超声双模成像和光动力治疗的新型纳米探针研究,2017/01-2019/12,17万元。
7. 中国博士后面上二等资助,2015M571959,双重响应性纳米药物载体用于靶向治疗肝癌的研究,2015/06-2016/12,5万元。
8. 福建省科技创新联合资金项目(攀登项目),2019Y9046,细胞源性微囊泡协同增强抗肿瘤免疫效应,2020.9-2023.8,50万元。
9. 福建省科技创新联合资金项目(引领项目),2016Y9061,肿瘤信号分子触发“诊疗一体化”纳米探针的研究,2016/09-2019/09,15万元。
10. 福建省自然科学基金面上项目,2022J011282,拮抗VEGF和PD-L1的仿生纳米囊泡用于肝癌免疫治疗的研究,2022.8-2025.8,10万元。
11. 福建省自然科学基金青年创新项目,2015J05175,肿瘤微环境触发靶向定位的磁共振影像纳米探针的研究,2015/04-2018/04,8万元。
12. 福建省卫生教育联合攻关计划项目,2019-WJ-20,生物来源纳米囊泡在肿瘤免疫治疗中的研究,2019/12-2022/12,20万元。
13. 福建省卫计委青年科研课题,2014-1-75,基于智能电荷翻转和还原响应性双功能聚合物纳米粒输送化疗药物的研究,2015/01-2017/01,3万元。
14. 福建省卫计委中青年骨干人才培养项目,2017-ZQN-75,化学发光用于肿瘤光动力治疗的研究,2017/09-2020/08,20万元。
15. 福州市科技创新创业人才培育计划项目,2021-R-105,基于细胞膜囊泡的肝癌免疫治疗新策略研究,2021.6-2023.5,50万元。
16. 福州市对外科技合作项目, 2022-Y-007,靶向PD-L1的CRISPR/Cas9腺病毒系统在肿瘤免疫治疗中的应用,2022.6-2024.6,30万元。
17. 福州市科技计划项目,2014-S-139-6,新型聚乙二醇衍生物用于化疗药物的肝癌靶向可控输送研究,2014/07-2017/07,5万元。
18. 福州市卫生健康中青年人才科研项目,2022-S-rc1,红细胞-聚氨酯载体系统用于肝癌新抗原疫苗研发,2023.6-2026.5,50万元。
19. 福州市卫健委创新团队项目,2020-S-wt7,细胞膜材料在肿瘤免疫抑制性微环境调控中的研究,2020.10-2023.10,16万元。
代表性论文:
1. Ming Wu#, Zijin Luo#, Zhixiong Cai#, Qianqian Mao, Zhenli Li, Hao Li, Cao Zhang, Yuting Zhang, Aoxue Zhong, Liming Wu*, Xiaolong Liu*, Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma, EMBO Molecular Medicine, 2023, 15, e16836. 中科院一区,IF: 11.1,第一作者
2. Lei Ding#, Xiaolong Zhang#, Peiwen Yu, Fang Peng, Yupeng Sun, Yanni Wu, Zijin Luo, Hongsheng Li, Yongyi Zeng, Ming Wu*, Xiaolong Liu*, Genetically Engineered Nanovesicles Mobilize Synergistic Antitumor Immunity by ADAR1 Silence and PDL1 Blockade, Molecular Therapy, 2023, 31, 2489-2506. 中科院一区,IF: 12.4,共同通讯作者
3. Ming Wu#, Hao Li#, Cao Zhang#, Yingchao Wang#, Cuilin Zhang, Yuting Zhang, Aoxue Zhong, Da Zhang*, Xiaolong Liu*, Silk-gel powered adenoviral vector enables robust genome editing of PD-L1 to augment immunotherapy across multiple tumor models, Advanced Science, 2023, 10, 2206399. 中科院一区,IF: 15.1,第一作者
4. Da Zhang#, Ziguo Lin#, Ming Wu#, Zhixiong Cai, Youshi Zheng, Lei He, Zhenli Li, Jie Zhou,
Liqin Sun, Geng Chen, Yongyi Zeng, Juan Li, Jingfeng Liu*, Huanghao Yang*, Xiaolong Liu*, Cytosolic Delivery of Thiolated Neoantigen Nano-Vaccine Combined with Immune Checkpoint Blockade to Boost Anti-Cancer T Cell Immunity, Advanced Science, 2021, 8, 2003504. 中科院一区,IF: 15.1,共同第一作者
5. Jiong Li#, Sijia Wang#, Xinyi Lin, Yanbing Cao, Zhixiong Cai, Jing Wang, Zhenxi Zhang, Xiaolong Liu, Ming Wu*, Cuiping Yao*, Red blood cell‑mimic nanocatalyst triggering radical storm to augment cancer immunotherapy, Nano-Micro Letters, 2022, 14, 57. 中科院一区,IF: 26.6,共同通讯作者
6. Dongye Zheng#, Peiwen Yu#, Zuwu Wei, Cheng Zhong, Ming Wu*, Xiaolong Liu*, RBC membrane camoufaged semiconducting polymer nanoparticles for near‑infrared photoacoustic imaging and photothermal therapy, Nano-Micro Letters, 2020, 12, 94. 中科院一区,IF: 26.6,共同通讯作者
7. Qianqian Mao#, Juan Min#, Rui Zeng#, Haiqin Liu, Hao Li, Cao Zhang, Aixian Zheng, Jiumao Lin*, Xiaolong Liu*, Ming Wu*, Self-assembled traditional Chinese nanomedicine modulating tumor immunosuppressive microenvironment for colorectal cancer immunotherapy, Theranostics, 2022, 12, 6088-6105. 中科院一区,IF: 12.4,最后通讯作者
8. Ming Wu, Lingjie Wu, Jiong Li, Da Zhang, Shanyou Lan, Xiaolong Zhang, Xinyi Lin, Gang Liu, Xiaolong Liu*, Jingfeng Liu*, Self-luminescing theranostic nanoreactors with intraparticle relayed energy transfer for tumor microenvironment activated imaging and photodynamic therapy, Theranostics, 2019, 9, 20-33. 中科院一区,IF: 12.4,第一作者,封面文章
9. Xinyi Lin#, Ming Wu#, Ming Li, Zhixiong Cai, Haiyan Sun, Xionghong Tan, Jiong Li, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, Photo-responsive hollow silica nanoparticles for light-triggered genetic and photodynamic synergistic therapy, Acta Biomaterialia, 2018, 76, 178-192. 中科院一区,IF: 9.7,共同第一作者
10. Yiru Wang, Ming Wu#, Xiaorong Wang#, Peiyuan Wang, Zhaoyu Ning, Yongyi Zeng, Xiaolong Liu, Haiyan Sun*, Aixian Zheng*, Biodegradable MnO2-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity, Materials Today Bio, 2023, 18, 100531. 中科院一区,IF: 8.2,共同第一作者
11. Wencheng Peng#, Yanbing Cao#, Yuting Zhang#, Aoxue Zhong, Cao Zhang, Zuwu Wei, Xiaolong Liu, Shoulong Dong, Jingcheng Wu, Yanan Xue*, Ming Wu*, Chenguo Yao*, Optimal irreversible electroporation combined with nano-enabled immunomodulatory to boost systemic antitumor immunity, Advanced Healthcare Materials, 2023, DOI: 10.1002/adhm.202302549. 中科院二区,IF: 10.0,共同通讯作者
12. Yanbing Cao#, De Wei#, Lixia Yang#, Zijin Luo, Peiwen Yu, Hao Li, Cao Zhang, Xiaolong Liu, Fengshou Wu*, Ming Wu*, Yongyi Zeng*, Nanoplatform Self-Assembly from Small Molecules of Porphyrin Derivatives for NIR-II Fluorescence Imaging Guided Photothermal-Immunotherapy, Advanced Healthcare Materials, 2022, 11, 2102526. 中科院二区,IF: 10.0,共同通讯作者
13. Jiong Li#, Zuwu Wei#, Xinyi Lin, Dongye Zheng, Ming Wu*, Xiaolong Liu*, Jingfeng Liu*, Programmable therapeutic nanodevices with circular amplification of H2O2 in the tumor microenvironment for synergistic cancer therapy, Advanced Healthcare Materials, 2019, 8, 1801627. 中科院二区,IF: 10.0,共同通讯作者
14. Ming Wu#, Dongye Zheng#, Da Zhang#, Peiwen Yu, Lianli Peng, Feng Chen, Ziguo Lin, Zhixiong Cai, Jiong Li, Zuwu Wei, Xinyi Lin, Jingfeng Liu*, Xiaolong Liu*, Converting immune cold into hot by biosynthetic functional vesicles to boost systematic antitumor immunity, iScience, 2020, 23, 101341. Cell Press,中科院二区,IF: 5.8,第一作者
15. Yuting Zhang#, Aoxue Zhong#, Juan Min#, Haibin Tu, Yanbing Cao, Jinghao Fu, Yonghao Li, Xiaolong Liu, Yong Yang, Jianmin Wang*, Jingfeng Liu*, Ming Wu*, Biomimetic responsive nanoconverters with immune checkpoint blockade plus antiangiogenesis for advanced hepatocellular carcinoma treatment, ACS Applied Materials & Interfaces, 2024, 16, 6894-6907. 中科院二区,IF: 9.5,最后通讯作者
16. Ming Wu#, Xinyi Lin#, Da Zhang, Youshi Zheng, Ai-Xian Zheng, Bixing Zhao, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, Photoresponsive nanovehicle for two independent wavelength light-triggered sequential release of P-gp shRNA and doxorubicin to optimize and enhance synergistic therapy of multidrug-resistant cancer, ACS Applied Materials & Interfaces, 2018, 10, 19416-19427. 中科院二区,IF: 9.5,第一作者
17. Yanbing Cao#, Juan Min#, Dongye Zheng, Jiong Li, Yanan Xue*, Faquan Yu*, Ming Wu*, Vehicle-saving theranostic probes based on hydrophobic iron oxide nanoclusters using doxorubicin as a phase transfer agent for MRI and chemotherapy, Chemical Communications, 2019, 55, 9015-9018. 中科院二区,IF: 4.9,最后通讯作者
18. Fangqin Xue, XiaoLin, Zhixiong Cai, Xiaolong Liu, Yuan Ma*, MingWu*, Doxifluridine-based pharmacosomes delivering miR-122 as tumor microenvironments-activated nanoplatforms for synergistic treatment of hepatocellular carcinoma, Colloids and Surfaces B: Biointerfaces, 2021, 197, 111367. 中科院二区,IF: 5.8,最后通讯作者
19. Haolan Li, Liangliang Yue, Ming Wu*, Fengshou Wu*, Self-assembly of methylene violet-conjugated perylene diimide with photodynamic/photothermal properties for DNA photocleavage and cancer treatment, Colloids and Surfaces B: Biointerfaces, 2020, 196, 111351. 中科院二区,IF: 5.8,共同通讯作者
20. Ming Wu, Qingtang Wang, Da Zhang, Naishun Liao, Lingjie Wu, Aimin Huang, Xiaolong Liu*, Magnetite nanocluster@poly(dopamine)-PEG@indocyanine green nanobead with magnetic field-targeting enhanced MR imaging and photothermal therapy in vivo, Colloids and Surfaces B: Biointerfaces, 2016, 141, 467-475. 中科院二区,IF: 5.8,第一作者
21. Naishun Liao#, Ming Wu#, Fan Pan, Jiumao Lin, Zuanfang Li, Da Zhang, Yingchao Wang, Youshi Zheng, Jun Peng, Xiaolong Liu*, Jingfeng Liu*, Poly (dopamine) coated superparamagnetic iron oxide for noninvasive labeling, tracking, and targeted delivering adipose tissue-derived stem cells, Scientific Reports, 2016, 6, 18746. 中科院二区,IF: 4.6,共同第一作者
22. Xiao Lin, Xiaofang Song, Yiwei Zhang, Yanbing Cao, Yanan Xue, Fengshou Wu, Faquan Yu*, Ming Wu*, Xunjin Zhu*, Multifunctional theranostic nanosystems enabling photothermal-chemo combination therapy of triple-stimuli-responsive drug release with magnetic resonance imaging, Biomaterials Science, 2020, 8,1875-1884. 中科院三区,IF: 6.6,共同通讯作者
23. Xiao Lin, Yanbin Cao, Jiong Li, Dongye Zheng, Shanyou Lan, Yanan Xue, Faquan Yu*, Ming Wu*, Xunjin Zhu*, Folic acid-modified Prussian blue/polydopamine nanoparticles as an MRI agent for use in targeted chemo/photothermal therapy, Biomaterials Science, 2019, 7, 2996-3006. 中科院三区,IF: 6.6,共同通讯作者
24. Jiong Li, Xuandong Wang, Dongye Zheng, Xinyi Lin, Zuwu Wei, Da Zhang, Zhuanfang Li, Yun Zhang, Ming Wu*, Xiaolong Liu*, Cancer cell membrane-coated magnetic nanoparticles for MR/NIR fluorescence dual-modal imaging and photodynamic therapy, Biomaterials Science, 2018, 6, 1834-1845. 中科院三区,IF: 6.6,共同通讯作者
25. Ming Wu#, Jiong Li#, Xinyi Lin, Zuwu Wei, Da Zhang, Bixing Zhao, Xiaolong Liu*, Jingfeng Liu*, Reduction/photo dual-responsive polymeric prodrug nanoparticles for programmed siRNA and doxorubicin delivery, Biomaterials Science, 2018, 6, 1457-1468. 中科院三区,IF: 6.6,第一作者
26. Kecan Lin#, Yanbing Cao#, Dongye Zheng, Qin Li, Hui Liu, Peiwen Yu, Jiong Li, Yanan Xue,Ming Wu*, Facile phase transfer of hydrophobic Fe3O4@Cu2-xS nanoparticles by red blood cell membrane for MRI and phototherapy in the second near-infrared window, Journal of Materials Chemistry B, 2020, 8, 1202-1211. 中科院三区,IF: 7,最后通讯作者
27. Lingjie Wu#, Ming Wu#, Xinyi Lin, Xiaolong Zhang, Xiaolong Liu*, Jingfeng Liu*, Magnetite nanocluster and paclitaxel loaded charge-switchable nanohybrids for MR Imaging and chemotherapy, Journal of Materials Chemistry B, 2017, 5: 849-857. 中科院三区,IF: 7,共同第一作者
28. Ming Wu, Xi-Ming Xia, Can Cui, Ping Yu, Yang Zhang, Lei Liu, Ren-Xi Zhuo, Shi-Wen Huang*, Highly efficient loading of amorphous paclitaxel in mesoporous hematitenanorods and their in vitro antitumor activity, Journal of Materials Chemistry B, 2013, 1, 1687-1695. 中科院三区,IF: 7,第一作者
29. Wencheng Peng#, Yaqi Yue#, Yuting Zhang#, Hao Li, Cao Zhang, Peiyuan Wang, Yanbing Cao, Xiaolong Liu, Shoulong Dong, Ming Wu*, Chenguo Yao*, Scheduled dosage regimen by irreversible electroporation of loaded erythrocytes for cancer treatment, APL Bioengineering, 2023, 7, 046102.中科院三区,IF: 6,共同通讯作者。被美国物理学联合会“科学之光”(Scilight)专题文章采访报道(专访报道链接:https://doi.org/10.1063/10.0022042).
30. Mingbin Huang#, Chao Xu#, Sen Yang, Ziqian Zhang, Zuwu Wei*, Ming Wu*, Fangqin Xue*, Vehicle-Free Nanotheranostic Self-Assembled from Clinically Approved Dyes for Cancer Fluorescence Imaging and Photothermal/Photodynamic Combinational Therapy, Pharmaceutics, 2022, 14, 1074. 中科院三区,IF: 5.4,共同通讯作者
31. Peiwen Yu#, Dongye Zheng#, Cuilin Zhang, Ming Wu*, Xiaolong Liu*, Protocol to prepare functional cellular nanovesicles with PD1 and TRAIL to boost antitumor response, Star Protocols, 2021, 2, 100324. Cell Press,共同通讯作者
32. Zhaokun Yan#, Qingtang Wang#, Xiaolong Liu, Jun Peng, Qin Li, Ming Wu*, Jiumao Lin*, Cationic nanomicelles derived from Pluronic F127 as delivery vehicles of Chinese herbal medicine active components of ursolic acid for colorectal cancer treatment, RSC Advances, 2018, 8, 15906-15914. 中科院三区,IF: 3.9,共同通讯作者
33. Ming Wu#, Qingtang Wang#, Xiaolong Liu*, Jingfeng Liu*, Highly efficient loading of doxorubicin in Prussian Blue nanocages for combined photothermal/chemotherapy against hepatocellular carcinoma, RSC Advances, 2015, 5, 30970-30980. 中科院三区,IF: 3.9,第一作者
34. Lingjie Wu#, Ming Wu#, Yongyi Zeng, Da Zhang, Aixian Zheng, Xiaolong Liu*, Jingfeng Liu*, Multifunctional PEG modified DOX loaded mesoporous silica nanoparticle@CuS nanohybrids as photo-thermal agent and thermal-triggered drug release vehicle for hepatocellular carcinoma treatment, Nanotechnology, 2015, 26, 025102. 中科院四区,IF: 3.5,共同第一作者
35. Ming Wu, Da Zhang, Yongyi Zeng, Lingjie Wu, Xiaolong Liu*, Jingfeng Liu*, Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy, Nanotechnology, 2015, 26, 115102. 中科院四区,IF: 3.5,第一作者,2015年度热点论文
36. Cuiping Yao#, Ming Wu#*, Cecheng Zhang, Xinyi Lin, Zuwu Wei, Youshi Zheng, Da Zhang, Zhenxi Zhang*, Xiaolong Liu*, Photoresponsive lipid-polymer hybrid nanoparticles for controlled doxorubicin release, Nanotechnology, 2017, 28, 255101. 中科院四区,IF: 3.5,共同第一作者
37. Xiao Lin, Yanbing Cao, Yanan Xue, Fengshou Wu, Faquan Yu*, Ming Wu*, Xunjin Zhu*, Multifunctional theranostic agents based on prussian blue nanoparticles for tumor targeted and MRI-guided photodynamic/photothermal combined treatment, Nanotechnology, 2020, 31, 135101. 中科院四区,IF: 3.5,共同通讯作者