廖乃顺:博士,助理研究员,福州市高层次D类人才;主持福建省自然科学基金等省部级/厅级项目8项,以主要技术骨干参与国家自然科学基金重点项目、面上项目等国家级项目5项;以第一作者或通讯作者在Angew. Chem. Int. Edit.,ACS Nano,Stem Cell Research & Therapy,Nanoscale等国内外期刊发表学术论文,High-index 22,多篇论文被Chemical Reviews, Chemical Society Reviews引用,他引累计1275次;授权国家发明专利3项;兼任福建省实验动物学会理事,福建省实验动物学会青年委员会常务委员,福建医科大学孟超肝胆医院干细胞临床研究学术委员会秘书,福建医科大学孟超肝胆医院实验动物伦理委员会委员,福建省孟超肝胆技术联合创新重点实验室科研秘书,Stem Cell Research & Therapy, Tissue Cell等杂志审稿人;获福州市自然科学优秀论文奖2项。
研究方向
主要从事细胞治疗、细胞功能活体成像研究。
主持承担的科研项目:
1. 福建省自然科学基金面上项目,2020J011152,从NOX4/ROS途径研究还原型谷胱甘肽提高脂肪间充质干细治疗肝硬化移植效率的机制,2020/11-2023/11,7万,已结题
2. 福州市科技局医疗卫生项目,2020-WS-56,GSH提高ADSC治疗肝硬化移植效率的作用机制及转化医学研究,2020/06-2022/12,3万,已结题
3. 福建医科大学启航基金项目,2018QH1198,褪黑素对ROS诱发脂肪干细胞氧化损伤、衰老的保护作用及其机制研究,2018/12-2021/11,5万,已结题
4. 福建省卫生健康青年科研课题,2017-1-85,用于调控脂肪干细胞向肝细胞定向分化的新型光控纳米复合物研究,2017/7-2020/6,3万,已结题
5. 福建医科大学启航基金项目,2016QH081,纳米材料介导的基因修饰脂肪干细胞向肝细胞分化的研究,2016/7-2019/8,5万,已结题
6. 福州市科技局社会发展项目,2016-S-124-9,还原敏感TLS11a杂化适配体用于肝癌的实时检测与光动力、化学协同治疗,2016/3-2018/3,3万,已结题
7. 福州市卫生系统科技计划项目,2014-S-w17,基于细胞片层技术构建血管化肝组织片层的研究,2014/9-2016/8,5万,已结题
8. 福州市卫生系统科技计划项目,2013-S-wq15,基于细胞片层技术构建肝组织片层的研究,2013/12-2015/12,2万,已结题
代表性论文:
1. Yu S, Yu S, Liu H, Liao N*, Liu X*. Enhancing mesenchymal stem cell survival and homing capability to improve cell engraftment efficacy for liver diseases. Stem Cell Res. Ther., 2023, 14: 235.
2. Liao N#, Su L#, Cao Y, Qiu L, Xie R, Peng F, Cai Z, Liu X, Song J*, Zeng Y*. Tracking Cell Viability for Adipose-Derived Mesenchymal Stem Cell-Based Therapy by Quantitative Fluorescence Imaging in the Second Near-Infrared Window. ACS Nano, 2022, 16:2889-2900.
3. Liao N#, Su L#, Zheng Y, Zhao B, Wu M, Zhang D, Yang H, Liu X*, Song J*. In Vivo tracking of cell viability for adoptive natural killer cell-based immunotherapy by ratiometric NIR-II fluorescence imaging. Angew. Chem. Int. Edit., 2021, 60: 20888-20896.
4. Liao N#, Zhang D#, Wu M, Yang H, Liu X*, Song J*. Enhancing therapeutic effects and in vivo tracking of adipose tissue derived mesenchymal stem cells for liver injury using bioorthogonal click chemistry. Nanoscale, 2021, 13:1813-1822.
5. Liao N, Shi Y, Wang Y, Liao F, Zhao B, Zheng Y, Zeng Y, Liu X*, Liu J*. Antioxidant preconditioning improves therapeutic outcomes of adipose tissue-derived mesenchymal stem cells through enhancing intrahepatic engraftment efficiency in a mouse liver fibrosis model. Stem Cell Res. Ther., 2020, 11: 237.
6. Zheng Y#, Liao N#, Wu Y, Gao J, Li Z, Liu W, Wang Y, Li M, Li X, Chen L, Zhang W*, Zhao B*. High expression of B7H2 or B7H3 is associated with poor prognosis in hepatocellular carcinoma. Mol. Med. Rep., 2019, 19: 4315-25.
7. Liao N, Shi Y, Zhang C, Zheng Y, Wang Y, Zhao B, Zeng Y, Liu X*, Liu J*. Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion. Stem Cell Res. Ther., 2019, 10: 306.
8. Xie H#, Liao N#, Lan F, Cai Z, Liu X*, Liu J*. 3D-cultured adipose tissue-derived stem cells inhibit liver cancer cell migration and invasion through suppressing epithelial-mesenchymal transition. Int. J. Mol. Med., 2018, 41: 1385-96.
9. Wang G#, Zheng Y#, Wang Y, Cai Z, Liao N*, Liu J, Zhang W*. Co-culture system of hepatocytes and endothelial cells: two in vitro approaches for enhancing liver-specific functions of hepatocytes. Cytotechnology, 2018, 70: 1279-90.
10. Liao N, Zheng Y, Xie H, Zhao B, Zeng Y, Liu X*, Liu J*. Adipose tissue-derived stem cells ameliorate hyperglycemia, insulin resistance and liver fibrosis in the type 2 diabetic rats. Stem Cell Res. Ther., 2017, 8: 286.
11. Liao N#, Wu M#, Pan F, Lin J, Li Z, Zhang D, Wang Y, Zheng Y, Peng J, Liu X*, Liu J*. Poly (dopamine) coated superparamagnetic iron oxide nanocluster for noninvasive labeling, tracking, and targeted delivery of adipose tissue-derived stem cells. Sci. Rep., 2016, 6: 18746.
12. Liao N, Pan F, Wang Y, Zheng Y, Xu B, Chen W, Gao Y, Cai Z, Liu X*, Liu J*. Adipose tissue-derived stem cells promote the reversion of non-alcoholic fatty liver disease: An in vivo study. Int. J. Mol. Med., 2016, 37: 1389-96.