郑晓源：理学硕士，研究实习员，毕业于厦门大学，就职于福建医科大学孟超肝胆医院/福建省联合创新重点实验室。主要从事肝癌免疫治疗以及肝癌类器官相关的基础研究。主持福建省自然科学基金面上项目，福建省卫健委科技计划项目等课题3项。以第一作者在Cell Death Discovery、Molecular Therapy Nucleic Acids、Small、Journal of Proteomics、The International Journal of Biochemistry & Cell Biology等SCI期刊发表论文8篇。
肝癌免疫治疗、肝癌类器官、肿瘤发生发展的分子机制
主持或参加的科研项目：
(1) 福建省卫健委，卫健委科技计划项目，2021QNA063，LncRNA RP11-201A3.1通过miR-23b/VCAN/Ecadherin信号轴调控肝癌侵袭转移的机制研究，2022-01 至 2024-12，10万元。
(2) 福建省科技厅，自然科学基金资助项目，2021J011291，低氧诱导甲基转移酶METTL16介导的m6A甲基化调节肝癌侵袭转移的分子机制研究，2021-11 至 2024-11， 7万元。
(3) 福州市卫健委, 福州市卫生健康科技计划项目, 2021-S-wq21，利用CRISPR/Cas9文库筛选肝细胞癌中仑伐替尼耐药基因的研究，2021-09 至 2024-09，2万元。
代表性论文：
1. Bixing Zhao#; Xiaoyuan Zheng#; Yang Wang#; Niangmei Cheng#; Yue Zhong; Yang Zhou; Jingyun Huang; Jingyun Huang; Fei Wang; Xin Qi; Qiuyu Zhuang; Yingchao Wang; Xiaolong Liu ; Lnc-CCNH-8 promotes immune escape by up-regulating PD-L1 in hepatocellular carcinoma, Molecular Therapy Nucleic Acids., 2024, 35(1): 1-15
2.Yingchao Wang#; Yue Zhong￥; Xiaoyuan Zheng#; Niangmei Cheng; Yong Yang; Ye Yang; Fei Wang;Bixing Zhao; Xiaolong Liu ; LncRNA TIALD contributes to hepatocellular carcinoma metastasis via inducing AURKA lysosomal degradation, Cell Death Discovery, 2023, 9(1)
3.Zhang D#;Jiang C#;Zheng X#;Lin Z#;Zhuang Q;Xie H; Liang Y; Xu Y;Cui L;Liu X*;Zeng Y*. Normalization of Tumor Vessels by Lenvatinib-Based Metallo-Nanodrugs Alleviates Hypoxia and Enhances Calreticulin-Mediated Immune Responses in Orthotopic HCC and Organoids. Small. 2023 Apr 13:e2207786.
4.Sun Ying#; Zheng Xiaoyuan#; Yuan Hui; Chen Geng; Ouyang Jiahe; Liu Jingfeng; Liu Xiaolong*;Xing Xiaohua*; Zhao Bixing* ; Proteomic Analyses Reveal Divergent Ubiquitylation Patterns in Hepatocellula Carcinoma Cell Lines with Different Metastasis Potential, Journal of Proteomics,2020, 225(103834):103834
5.Zhao Bixing#; Zheng Xiaoyuan#; Tan Xionghong#; Ke Kun; Wang Fei; Wang Yingchao; Xing Xiaohua; Zhang Cuilin; Hu Ping; Lan Shubing; Li Qin; Huang Aimin*; Liu Xiaolong*; Ku80 Negatively Regulates the Expression of OCT4 Via Competitive Binding to SALL4 and Promoting LysosomalDegradation of OCT4, The International Journal of Biochemistry & Cell Biology, 2020, 118(105664):105664
6.Lan S, Zheng X, Hu P, Xing X, Ke K, Wang F, Cheng N, Zhuang Q, Liu X, Liu J, Zhao B, Wang Y. Moesin facilitates metastasis of hepatocellular carcinoma cells by improving invadopodia formation and activating β-catenin/MMP9 axis. Biochem Biophys Res Commun. 2020 Apr 16;524(4):861-868.
7.Liu Z, Ning J, Zheng X, Meng J, Han L, Zheng H, Zhong L, Chen XF, Zhang X, Luo H, Can D, Xu H, Zhang YW. TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities. Cell Death Dis. 2020 Aug 13;11(8):678.
8.Qiuyang Zheng; Xiaoyuan Zheng; Lishan Zhang; Hong Luo; Lingzhi Qian; Xing Fu; Yiqian Liu;Yuehong Gao; Mengxi Niu; Jian Meng; Muxian Zhang; Guojun Bu; Huaxi Xu; Yun-wu Zhang*; The NeuronSpecific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death, Molecular Neurobiology,2016, 54(6): 4189-4200