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王菲 研究实习员     进组时间: 2017年

王菲:理学硕士,毕业于厦门大学微生物学专业。福建医科大学孟超肝胆医院实习研究员。主要从事肿瘤相关信号转导通路,蛋白质组学,分子免疫学方面得基础与临床转化研究,主持并参与多项自然科学基金。

 

主持承担的科研项目:

1.      福建医科大学启航基金项目,2018QH1199MYPT1促进肝癌细胞转移/侵袭机理研究,201812月至202111月,5万元,在研,主持。

2.      福建省自然科学基金计划项目,探索长链非编码RNA FAM99A在肝癌转移/侵袭中发挥的作用及其作用机制,2018年3月至2021年2月,5万元,在研,主持。

 

代表性论文:

1.         Wang F#, Wu H#, Zhang S#, Lu J, Lu Y, Zhan P, Fang Q, Wang F, Zhang X, Xie C*, Yin Z*. LAPTM4B facilitates tumor growth and induces autophagy in hepatocellular carcinoma. Cancer Manag Res. 2019 Mar 27;11:2485-2497

 

2.         Zheng S#, Wu H#, Wang F#, Lv J, Lu J, Fang Q, Wang F, Lu Y, Zhang S, Xu Y, Bao Q, Xie C*, Yin Z*. The oncoprotein HBXIP facilitates metastasis of hepatocellular carcinoma cells by activation of MMP15 expression. Cancer Manag Res. 2019 May 16;11:4529-4540.

 

3.         Xie CR, Wang F, Zhang S, Wang FQ, Zheng S, Li Z, Lv J, Qi HQ, Fang QL, Wang XM, Yin ZY*. Long Noncoding RNA HCAL Facilitates the Growth and Metastasis of Hepatocellular Carcinoma by Acting as a ceRNA of LAPTM4B. Mol Ther Nucleic Acids. 2017, 9:440-451

 

4.         Bixing Zhao#, Xiaoyuan Zheng#, Xionghong Tan, Kun Ke, Fei Wang, YingchaoWang, Xiaohua Xing, Cuilin Zhang, Ping Hu, Shubing Lan, Qin Li Aimin Huang*, and Xiaolong Liu*. Ku80 negatively regulates the expression of OCT4 via competitive binding to SALL4 and promoting lysosomal degradation of OCT4. The International Journal of Biochemistry & Cell Biology. 2020,118:105664.

5.         Zhang, X., Wang F., Huang Y., Ke K., Zhao B., Chen L., Liao N., Wang L., Li Q., Liu X., Wang Y.*, and Liu J., FGG promotes migration and invasion in hepatocellular carcinoma cells through activating epithelial to mesenchymal transition. Cancer Manag Res, 2019. 11: p. 1653-1665.