陈耕:理学博士,福建医科大学孟超肝胆医院助理研究员。目前主要从事于肿瘤二代测序的生物信息学数据分析及肝癌相关精准医疗与诊断预后标志物筛选等研究工作。主持福建省自然科学基金项目与福州市级科技课题等多个省部/厅局级项目。发表SCI论文20余篇,其中以第一作者身份在IJC, Clinical Cancer Research,Nuclear Acid Research等国际知名期刊发表SCI论文17篇。
研究方向:
生物信息学 肿瘤基因组学 液态活检
主持科研项目:
1. 国家自然科学基金青年项目,82303965,循环游离DNA追踪肝癌肿瘤克隆演化预测经肝动脉化疗栓塞疗效,2024/1-2026/12,主持。
2. 福建省自然科学基金计划项目,2018J01145,基于二代测序技术的肝癌基因组突变特征的研究,2018/4-2021/4,6万元,已结题,主持。
3. 福建省自然科学基金计划项目,2021J011297,cfDNA突变谱特征用于肝癌诊断及预后评估的研究,2021/11-2024/11,7万元,已结题,主持。
4. 福州市卫生系统科技计划项目,2015-S-143-21,肝癌中差异表达的lncRNA及其相互作用miRNA的生物信息学分析,2015/4-2018/3,3万元,已结题,主持。
代表性论文 :
1. Chen Geng; Cai Zhixiong; Li Zhenli; Dong Xiuqing; Xu Haipo; Lin Jianling; Chen Lihong; Zhang Huqin; Liu Xiaolong; Liu Jingfeng ; Clonal evolution in long-term follow-up patients with hepatocellular carcinoma, International Journal of Cancer, 2018, 143(11): 2862-2870
2. Cai Zhixiong; Chen Geng; Zeng Yongyi; Dong Xiuqing; Lin Minjie; Huang Xinhui; Zhang Da; Liu Xiaolong; Liu Jingfeng ; Circulating tumor DNA profiling reveals clonal evolution and real-time disease progression in advanced hepatocellular carcinoma., International Journal of Cancer,2017, 141(5): 977-985
3. Cai Zhixiong; Chen Geng; Zeng Yongyi; Dong Xiuqing; Li Zhenli; Huang Yanbing; Xin Fuli; Qiu Liman; Xu Haipo; Zhang Wei; Su Xiaoping; Liu Xiaolong; Liu Jingfeng ; Comprehensive liquid profiling of circulating tumor DNA and protein biomarkers in long-term follow-up patients with hepatocellular carcinoma, Clinical Cancer Research, 2019, 25(17): 5284-5294
4. Li Zhenli; Chen Geng; Cai Zhixiong; Dong Xiuqing; Qiu Liman; Xu Haipo; Zeng Yongyi; Liu Xiaolong; Liu Jingfeng ; Genomic and transcriptional Profiling of tumor infiltrated CD8+ T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma, Oncoimmunology, 2018, 8(2): e1538436
5. Chen Geng; Wang Rendong; Zhang Chen; Gui Lijia; Xue Yuan; Ren Xianlin; Li Zhenli; Wang Sijia; Zhang Zhenxi; Zhao Jing; Zhang Huqing; Yao Cuiping; Wang Jing; Liu Jingfeng ; Integration of pre-surgical blood test results predict microvascular invasion risk in hepatocellular carcinoma, Computational and Structural Biotechnology Journal, 2021, 19: 826-834