董秀清:理学硕士,助理研究员。2015年至今就职于福建医科大学孟超肝胆医院重点实验室,主要从事遗传代谢性肝病基因检测,肝癌精准医疗等相关工作。主持并参与多项自然科学基金,以第一作者发表SCI论文5篇。
研究方向:
肿瘤精准医疗、肿瘤液体活检、遗传代谢性肝病检测
主持承担的科研项目:
1.福建省自然科学基金项目,2022J011288,循环肿瘤DNA监测肝癌术后微小残留病灶,2022/2025,10万元,在研,主持
2.福建省卫生健康青年科研课题,2020QNA073,基于循环肿瘤DNA拷贝数变异特征评估肝癌TACE治疗疗效,2020/-2023,5万元,在研,主持
3.福州市科技局社会发展项目,2017-S-131-3,肝癌肿瘤浸润CD8+T细胞mRNA表达谱的研究,2017/03-2020/03,5万元,结题,主持
4.福建医科大学启航基金,2016QH082,基于二代测序技术研究RNA编辑位点在肝癌发生发展中的作 用,2016/10-2019/9,5万元,结题,主持
5.福州市科技计划项目,2016-S-124-11,原发性肝细胞癌复发转移相关的RNA编辑表达谱研究,201 6/03-2018/02,3万元,结题,主持
代表性论文:
1.Xiuqing Dong, Bin Shen, Ningsheng Ruan,Zhen Guan, Yanding Zhang, YiPing Chen, Xuefeng Hu*,Expression patterns of genes critical for BMP signaling pathway in developing human primary tooth germs, Histochem Cell Biol,2014, 142(6):657-665
2.Xiuqing Dong#, Geng Chen#, Zhixiong Cai#, Zhenli Li, Liman Qiu, Haipo Xu,,Yuan Yuan, Xiaolong Liu*, Jingfeng Liu*, CDK13 RNA Over-Editing Mediated byADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients, Cell Physiol Biochem 2018;47:2602-26123
3.Zhenli Li#, Geng Chen#, Zhixiong Cai#, Xiuqing Dong#, Liman Qiu, Haipo Xu,Yongyi Zeng, Xiaolong Liu & Jingfeng Liu. Genomic and transcriptional Profiling of tumorinfiltrated CD8+T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma. November 2018 OncoImmunology 8(2):1-12.(共同第一作者)
4.Xiuqing Dong#, Geng Chen#, Xinghui Huang#, Zhenli Li, Fang Peng, Hengkai Chen,Yang Zhou, Lei He, Liman Qiu, Zhixiong Cai*, Jingfeng Liu*, and Xiaolong Liu*.Copy number profiling of circulating free DNA predicts transarterial chemoembolization response in advanced hepatocellular carcinoma. Molecular Oncology 16 (2022) 1986–1999
5.Geng Chen#; Fang Peng#; Xiuqing Dong#; Zhixiong Cai; Zhenli Li; Lei He; Jinpan Hu; Xiaoxu Deng; Yutong Guo; Liman Qiu; Yang Zhou; Jingfeng Liu; Huqin Zhang*; Xiaolong Liu*; Identification of tumor mutations in plasma based on mutation variant frequency change (MVFC), Molecular Oncology, 2023, 17(9): 1871-1883(共同第一作者)
获得荣誉称号及奖励:
1.华东地区第十三界实验动物科学学术交流会泰尼百斯杯优秀论文奖,2014年