林金明,工学博士,分析化学专业。1984年福州大学毕业,1992年在日本昭和大学国际交流基金的资助下前往该大学药学部从事访问研究。1994年获得日本政府奖学金转入东京都立大学攻读博士学位,1997年3月获得工学博士学位,同年留校任教,2000年入选中国科学院“百人计划”,受聘中科院生态环境研究中心研究员、博士生导师;2001年获得国家杰出青年科学基金,2002年3月底回国工作,2004年入选清华大学“百名人才引进计划”,受聘清华大学化学系教授、博士生导师。2008年受聘教育部长江学者特聘教授,2014年入选英国皇家化学会会士。目前主要从事1)微流控芯片质谱联用细胞分析方法研究;2)针对细胞检测的化学发光分析方法研究;3)复杂样品前处理与色谱分析; 4)分析新仪器、新设备的开发与研制。。已培养博士研究生43名(含联合培养,其中留学生2名)、硕士研究生28名、博士后11名(其中留学生3名)、访问学者10名(其中外国访问学者1名)。
研究领域
研究方向:生命与环境分析化学
1)微流控芯片质谱联用细胞分析
2)针对细胞检测的化学发光分析方法研究
3)复杂样品前处理与质谱分析
4)分析新仪器、新设备的开发与研制
(欢迎本系及外单位的师生加盟本研究组。每年接收博士生2名、硕士生1-2名、博士后2-3名、优秀访问学者1-2名。同时接收联合培养研究生)
学术兼职
Trends in Analytical Chemistry (Elsevier), Contributing Editor (2007.01-)
Journal of Flow Injection Analysis (JAFIA, Japan), International Advisory Board (2007.01-)
International Journal of Analytical Chemistry (Hindawi), Editorial Board (2008.01-)
Talanta (Elsevier), Editorial Board, (2008.01-)
Recent Patents on Nanotechnology (Hindawi), Editorial Advisory Board (2008.01-)
Current Analytical Chemistry (Bentham), Associate Editor (2009.01-)
Luminescence (Wiley), Editorial Board (2009.01-2016.06)
Luminescence (Wiley), Associate Editor (2016.06-)
Toxicological & Environmental Chemistry (Taylor & Francis), Editorial Board (2011.01-2015.12)
Journal of Pharmaceutical Analysis (Xi’an Jiaoda and Elsevier), Associate Editor (2011.01-)
Chinese Chemical Letter(CCS, Elsevier), Editorial Board (2012.01-2015.12)
Chinese Chemical Letter(CCS, Elsevier), Editorial Board (2016.1-)
Analytica Chemica Acta (Elsevier), Editorial Board (2015.09-)
《分析试验室》副主编(2013.10-)
《分析化学》编委(2002.01-)
《环境科学》编委(2004.07-)
《分析试验室》编委(2003.07-)
《色谱》编委(2003.01-)
《分析科学学报》编委(2003.01-)
《化学通报》编委(2008.01-)
《生命科学仪器》编委(2004.01-)
《环境科学与技术》编委(2009.01-)
《食品安全质量检测技术》编委(2008.01-)
《应用化学》编委(2010.01-)
《中国科学:化学》编委(2013.01-)
中国化学会副秘书长(2011.01-2014.12)
中国化学会分析化学专业委员会副主任(2003.01-)
中国色谱学会理事(2003.07-)
北京市色谱学会理事(2004.08-)
中国预防医学会自由基专业委员会委员(2005.08-)
北京化工大学兼职教授(2001.09-)
福州大学兼职教授(2001.06-2006.05)
中国仪器仪表学会分析仪器分会第一届样品制备专业委员会副主任委员(2011.4.10-)
北京市食品安全分析测试工程技术研究中心学术委员会委员(2011.7.9-)
中国药学会药物分析专业委员会委员(2011.08-)
中国分析测试协会理事(2011.12.8-)
中国化学会产学研合作与促进委员会主任(2011.12-2014.12)
中国化学会质谱分析专业委员会秘书长兼副主任(2013.12-)
奖励与荣誉
1992 中国化学会优秀青年化学奖
1998 日本科学协会Sasakawa科学研究奖
2000 日本分析化学会流动注射分析进步奖
2000 入选中国科学院“百人计划”
2001 日本分析化学会关东支部新世纪奖
2001 获得国家杰出青年科学基金
2004 中国科学院“百人计划”终期评估优秀入选者
2004 入选清华大学“百名人才引进计划”
2007 获得国家自然科学基金海外青年合作基金
2008 日本分析化学会、日本流动注射分析协会FIA Award for Science
2008 日本气相色谱研究会成立50周年大会上获得“气相色谱研究贡献奖”
2008 受聘教育部“长江学者奖励计划”特聘教授
2009 中国分析测试协会科学技术奖(CAIA奖)一等奖
2009 国家质检总局“科技兴检奖”二等奖
2010 Eli Lilly亚洲优秀研究生论文导师奖
2010 中国分析测试协会科学技术奖(CAIA奖)一等奖
2010 辽宁省科学技术奖三等奖
2011 中国产学研合作促进会创新成果奖
2012 2012年度清华大学“纪念梅贻琦学术论文奖”二等奖
2013 日本分析化学会气相色谱研究会2013年度色谱研究贡献奖
2013 CJK杰出贡献奖(2013年中日韩分析化学研讨会)
2013 北京市科学技术奖二等奖(排名第一,疾病标记物的化学发光免疫分析试剂盒的研制)
2013 2013年度中国分析测试协会科学技术奖(CAIA奖)一等奖
2013 2013年度清华大学“纪念梅贻琦学术论文奖”二等奖
2014 仪器信息网“蜜蜂奖”
2014 清华大学2013年度国际合作与交流暨港澳台工作先进个人
2014 2014年度清华大学“纪念梅贻琦学术论文奖”二等奖
2014 英国皇家化学会会士
2015 《中国科学》(化学)2014年度优秀编委
2015 中国化学会分析化学委员会第八届“分析化学基础研究梁树权奖”
2016 教育部自然科学奖二等奖(排名第一,超微弱化学发光基础理论与新方法研究)
2016 “中国移动杯”暨第十届北京市发明创新大赛银奖
学术成果
Wanling Zhang, Sifeng Mao, Ziyi He, Zengnan Wu, Jin-Ming Lin*, In situ monitoring of fluid shear stress enhanced adherence of bacteria to cancer cells on microfluidic chip, Anal. Chem., 2019, DOI: 10.1021/acs.analchem.9b00394
Ning Xu, Haifeng Lin, Katsumi Uchiyama, Jin-Ming Lin*, On-site sampling of inorganic contamination on the metal surface and analysis with capillary electrophoresis, J. Sep. Sci., 2019, 42(8), 1593-1599
Jin-Qing Ma , Lu Liu , Xia Wang, Li-Zong Chen, Jin-Ming Lin, Ru-Song Zhao*, Development of dispersive solid-phase extraction with polyphenylene conjugated microporous polymers for sensitive determination of phenoxycarboxylic acids in environmental water samples, Journal of Hazardous Materials, 2019, 371, 433-439
Lu Liu, Wei-Kun Menga, Yan-Sheng Zhou, Xia Wang, Gui-Ju Xu, Ming-Lin Wang, Jin-Ming Lin, Ru-Song Zhao*,β-Ketoenamine-linked covalent organic framework coating for ultra-high-performance solid-phase microextraction of polybrominated diphenyl ethers from environmental samples, Chem. Eng. J., 2019, 356, 926-933.
Nan Li, Weifei Zhang, Ling Lin,* Syed Niaz Ali Shah, Yuxuan Li, Jin-Ming Lin*, A nongenetically encoded and erasable imaging strategy for receptor-specific glycans on live cells, Anal. Chem., 2019, 91(4), 2600-2604.
Shuo Feng#, Sifeng Mao#, Qiang Zhang, Weiwei Li, Jin-Ming Lin*, Online analysis of drug toxicity to cells with shear stress on an integrated microfluidic chip, ACS Sensors, 2019, 4(2), 521-527
Min Li, Sifeng Mao, Shiqi Wang, Hai-Fang Li*, Jin-Ming Lin *, Chip-based SALDI-MS for rapid determination of intracellular ratios of glutathione to glutathione disulfide, Sci. China Chem., 2019, 62, 142-150.
Leiwei Li, Mashooq Khan, Haifang Li, Ling Lin, Sifeng Mao, and Jin-Ming Lin*, Homogenous deposition of matrix-analyte cocrystals on gold-nanobowls array for improving MALDI-MS signal reproducibility, Chem. Commun., 2019, 55, 2166 – 2169.
Qiang Zhang, Sifeng Mao, Mashooq Khan, Shuo Feng, Wanling Zhang, Weiwei Li, Jin-Ming Lin*, In situ partial treatment of single cells by laminar flow in the “open space”, Anal. Chem., 2019, 91(2), 1644-1650
Sifeng Mao, Qiang Zhang, Wu Liu, Qiushi Huang, Mashooq Khan, Wanling Zhang, Caihou Lin, Katsumi Uchiyama, and Jin-Ming Lin*, Chemical operations on a living single cell by open microfluidics for wound repair studies and organelle transport analysis, Chem. Sci., 2019, 10, 2081-2087
Naoki Hamada, Yuki Hashi, Satoshi Yamaki, Yanli Guo, Lin Zhang, Haifang Li, Jin-Ming Lin*, Construction of on-line supercritical fluid extraction with reverse phase liquid chromatography-tandem mass spectrometry for the determination of capsaicin, Chinese Chemical Letters, 2019, 30(1), 99-102
Zengnan Wu, Ning Xu, Weiwei Li, Jin-Ming Lin*, A membrane separation technique for optimizing sample preparation of MALDI-TOF MS detection, Chinese Chemical Letters, 2019, 30, 95-98
Syed Niaz Ali Shah, Xiangnan Dou, Mashooq Khan, Katsumi Uchiyama, Jin-Ming Lin*, N-doped carbon dots/H2O2 chemiluminescence system for selective detection of Fe2+ ion in environmental samples, Talanta, 2019, 196, 370-375
Shiqi Wang, Sifeng Mao, Min Li, Hai-Fang Li* , Jin-Ming Lin*, Near-physiological microenvironment simulation on chip to evaluate drug resistance of different loci in tumour mass, Talanta, 2019, 191, 67-73
Xiangnan Dou, Qiang Zhang, Syed Niaz Ali Shah, Mashooq Khan, Katsumi Uchiyama, and Jin-Ming Lin*, MoS2-quantum dots triggered reactive oxygen species generation and depletion: responsible for enhanced chemiluminescence. Chemical Science, 2019, 10, 497-500
Qiushi Huang, Sifeng Mao, Mashooq Khan, and Jin-Ming Lin*, Single-cell assay on microfluidics (Review paper), Analyst, 2019, 144, 808-823
Ze-Hui Deng, Gui-Ju Xu, Xiao-Li Wang, Xia Wang, Ming-Lin Wang, Jin-Ming Lin, Ru-Song Zhao*, A Zr(IV)-based porphyrinic metal-organic framework as a solid-phase sorbent for extraction of sulfonamides prior to their quantitation by LC-MS, Microchimica Acta, 2018, 185, 450 (8 pages)
Zengnan Wu, Ling Lin, Mashooq Khan, Weifei Zhang, Sifeng Mao, Yajing Zheng, Zenghe Li, and Jin-Ming Lin*, DNA-mediated rolling circle amplification for ultrasensitive detection of thrombin using MALDI-TOF mass spectrometry, Chem. Commun., 2018, 54, 11546-11549
Nan Li, Weifei Zhang, Ling Lin,* Ziyi He, Mashooq Khan, and Jin-Ming Lin*, Live imaging of cell membrane-localized MT1-MMP activity on a microfluidic chip, Chem. Commun., 2018, 54, 11435-11438
Ling Lin,* Yu Li, Mashooq Khan, Jiashu Sun, and Jin-Ming Lin*, Real-time characterization of negative air ions-induced decomposition of indoor organic contaminants by mass spectrometry, Chem. Commun., 2018, 54, 10687-10690.
Sifeng Mao,† Qiang Zhang,† Haifang Li, Wanling Zhang, Qiushi Huang, Mashooq Khan, and Jin-Ming Lin*, Adhesion analysis of single circulating tumor cell on base layer of endothelial cells using open microfluidics, Chem. Sci., 2018, 9, 7694 – 7699
Caihou Lin, Ling Lin, Sifeng Mao, Lijuan Yang, Linglu Yi, Xuexia Lin, Junming Wang, Zhixiong Lin*, Jin-Ming Lin*, Reconstituting glioma perivascular niches on a chip for insights into chemoresistance of glioma, Anal. Chem., 2018, 90(17), 10326-10333
Weiwei Li, Mashooq Khan, Shuo Feng, Jin-Ming Lin*, Advances of tumor-endothelial cells co-culture and interaction on microfluidics (Review Paper), J. Pharm. Anal., 2018, 8, 210–218
Sifeng Mao, Qiang Zhang, Haifang Li, Qiushi Huang, Mashooq Khan, Katsumi Uchiyama, and Jin-Ming Lin*, Measurement of cell-matrix adhesion at single-cell resolution reveals the functions of biomaterials for adherent cell culture, Anal. Chem., 2018, 90, 9637-9643
Sifeng Mao, Weiwei Li, Qiang Zhang, Wanling Zhang, Qiushi Huang, Jin-Ming Lin*, Cell analysis on chip-mass spectrometry (Review Paper), Trends Anal. Chem., 2018, 107, 43-59
Naoki Hamada, Yanli Guo, Feng Ji, Lin Zhang, Satoshi Yamaki, Haifang Li, Yueqi Li, Yuki Hashi, Jin-Ming Lin*, Determination of vitamin D in oily drops using a column-switching system with an on-line clean-up by sup ercritical fluid chromatography, Talanta, 2018, 190, 9-14
Weifei Zhang, Nan Li, Yong Zhang, Hulie Zeng , Katsumi Uchiyama*, and Jin-Ming Lin *, Shell microparticles of morphology controlled and inner-modified hole from sequential inkjet-printed double emulsions, Science China Chemistry, 2018,
Guilong Peng, Yi Chen, Ruoyu Deng, Qiang He*, Dun Liu, Ying Lu, and Jin-Ming Lin*, Highly sensitive and selective determination of Hg(II) based on microfluidic chip with on-line fluorescent derivatization, Spectrochim. Acta A, 2018, 204, 1-6
Sifeng Mao, Yong Zhang, Qiang Zhang, Jin-Ming Lin*, and Katsumi Uchiyama*, Local surface modification at precise position using a chemical pen, Talanta, 2018, 187, 246–251
Mashooq Khan, Zengnan Wu, Sifeng Mao, Syed Niaz Ali Shah, and Jin-Ming Lin*, Controlled grafted poly(quartanized-4-vinylpyridine-co-acrylicacid) brushes allure bacteria for effective antimicrobial surfaces, Journal of Materials Chemistry B, 2018, 6, 3782-3791
Mashooq Khan, Sifeng Mao, Weiwei Li, and Jin-Ming Lin*, Microfluidic devices in the fast-growing domain of single-cell analysis(Review Paper), Chemistry - A European Journal, 2018, 24, 15398-15420
Lin Zhou, Sifeng Mao, Qiushi Huang, Xiangwei He*, and Jin-Ming Lin*, Inhibition of anaerobic probiotics on colorectal cancer cells using intestinal microfluidic systems, Science China Chemistry, 2018, 61(8), 1034–1042
Junming Wang, Sifeng Mao, Haifang Li*, and Jin-Ming Lin*, Multi-DNAzymes functionalized on gold nanoparticles by rolling circle amplification for highly sensitive detection of thrombin on microchip, Anal. Chim. Acta, 2018, 1027, 76-82
Weifei Zhang, Nan Li, Daisuke Koga, Yong Zhang, Hulie Zeng, Hizuru Nakajima, Jin-Ming Lin*, and Katsumi Uchiyama*, Inkjet printing based droplet generation for integrated online digital polymerase chain reaction, Anal. Chem., 2018, 90, 5329-5334
Ziyi He, Wanling Zhang, Sifeng Mao, Nan Li, Haifang Li, and Jin-Ming Lin*, Shear stress-enhanced internalization of cell membrane proteins indicated by a hairpin-type DNA probe, Anal. Chem., 2018, 90(9), 5540 -5545
Wei-Kun Meng, Lu Liu, Xia Wang, Ru-Song Zhao*, Ming-Lin Wang, and Jin-Ming Lin, Polyphenylene core-conjugated microporous polymer coating for highly sensitive solid-phase microextraction of polar phenol compounds in water samples, Anal. Chim. Acta, 2018, 1015, 27-34
Ji-Yun Ren, Xiao-Li Wang, Xiao-Li Li, Ming-Lin Wang, Ru-Song Zhao*, and Jin-Ming Lin, Magnetic covalent triazine-based frameworks as magnetic solid-phase extraction adsorbents for sensitive determination of perfluorinated compounds in environmental water samples, Anal. Bioanal.Chem, 2018,410, 1657-1665
Qiushi Huang, Sifeng Mao, Mashooq Khan, Lin Zhou, and Jin-Ming Lin*, Dean flow assisted-cell ordering system for lipid profiling in single-cells using mass spectrometry (Cover page), Chem. Commun., 2018, 54, 2595-2598
Zengnan Wu, Mashooq Khan, Sifeng Mao, Ling Lin*, Jin-Ming Lin*, Combination of nano-material enrichment and dead-end filtration for uniform and rapid sample preparation in matrix-assisted laser desorption/ionization mass spectrometry, Talanta, 2018,181, 217-223
Wanling Zhang, Ziyi He, Linglu Yi, Sifeng Mao, Haifang Li, and Jin-Ming Lin*, A dual-functional microfluidic chip for on-line detection of interleukin-8 based on rolling circle amplification, Biosensors and Bioelectronics, 2018,102, 652-660
Mingsha Jie, Haifeng Lin, Ziyi He, Hanyang Liu, Haifang Li, and Jin-Ming Lin*, An on-chip intestine-liver model for multiple drugs absorption and metabolism behavior simulation, Science China Chemistry, 2018,61(2), 236-242
Sifeng Mao, Wanling Zhang, Qiushi Huang, Masqooh Khan, Haifang Li, Katsumi Uchiyama and Jin-Ming Lin*, In situ scatheless cell detachment reveals connections between adhesion strength and viability at single-cell resolution, Angew. Chem. Int. Ed., 2018, 57, 236-240
Zhihui Zhong, Sifeng Mao, Haifeng Lin, Jin-Ming Lin*, and Jianhua Lin*, Comparative proteomics of cancer stem cells in osteosarcoma using ultra-high-performance liquid chromatography and Orbitrap Fusion mass spectrometer, Talanta, 2018,178C, 362-368
Nan Li, Weifei Zhang, Mashooq Khan, Ling Lin, and Jin-Ming Lin *, MoS2-LA-PEI nanocomposite carrier for real-time imaging of ATP metabolism in glioma stem cells co-cultured with endothelial cells on a microfluidic system, Biosensors and Bioelectronics, 2018, 99, 142–149