王学,女,副教授,硕士生导师
办公室:13号教学楼E227
邮箱:xuewang@sdut.edu.cn
个人基本情况
(1) 教育经历:
2001 / 9 – 2006 / 6 南京师范大学, 生命科学学院, 细胞生物学专业, 硕博连读, 获理学博士学位;
(2) 社会兼职:
中国细胞生物学学会会员
山东细胞生物学学会会员
主要研究方向及简介
1.生物小分子高效生物合成工程菌的构建及其中试工艺开发;
2.利用酿酒酵母缺失基因组文库筛选与药物作用相关的关键基因,力图揭示它们在真核生物细胞内的作用靶点及其分子机制,从而为医学、药学、农学等领域的科学研究奠定基础;
3.生物多样性和生态环境修复研究。
开设课程
细胞生物学与细胞工程、 生物技术制药
近年的项目、 论文、 专利、 获奖
项目:
(1)生物小分子高效生物合成工程菌的构建及其中试工艺开发,2022.12-2024.11,227万,主持
(2)淄博市生物多样性检测,2022.1-2022.12,主持
(3)机场和保护区生物多样性检测,2022-2023,主持
(4)山东省自然科学基金.重大基础研究项目.典型退化与污染农田土壤修复改良强化技术开发及其原理研究,参与.项目编号:ZR20200ZD192021.01-2023.12.300万。
(5)山东省自然科学基金面上项目,鞘脂菌V4降解花生化感物质酚酸的分子机制研究(ZR2021MC162),参与.2022-01至2024-12,10万。
(6)E.coli宿主细胞DNA残留检测试剂盒开发,横向项目,主持,10万。
(7)新冠病毒诊断用试剂质量评价用标准品鉴定研究,参与,横向项目。
(8)环境保护部“生物多样性保护专项”,2111101、生物多样性示范观测(山东黄河三角州和徂徕山观测样区)、2014.01-2019.12、41万、主持。
(9)山东省自然科学基金“水稻根细胞壁吸收累积稀土的分子机制研究”立项类型:面上项目(项目编号:ZR2014DM010,起止日期:2014.12-2017.12)15万、主持。
(10)山东理工大学青年教师发展支持计划项目,4072-112019、根表铁膜在水稻吸收转运稀土中的作用机理、2013.1-2015.12、8万、主持。
(11)国家自然科学基金青年科学基金项目,30900071、稀土对植物的Hormesis效应与钙离子信号传导关系的研究、2010.01-2012.12、20万元、主持。
(12)山东理工大学博士启动基金项目,4041-406027,多胺增强水稻抗稀土胁迫能力的机制研究、2006.9-2009.9、5万元、主持。论文:
2023
(1) Keliang Lyu, Zhiwen Lyu, Xinran Zhang, Donghao Hao, Zhonghuang Yang, Yumeng Liu,Dongwu Liu, Xue Wang (通讯作者). Effect of cerium on the production of reactive oxygen species in the root of Arabidopsis thaliana: an in vitro study. Microscopy Research and Technique. 2023, 86: 137–143.
2022
(1) Yuhang Cao, Caiyun Zhang, Yu Fang, Yumeng Liu, Kexin Lyu, Jian Ding, Xue Wang (通讯作者). Investigation the global effect of rare earth gadolinium on the budding Saccharomyces cerevisiae by genome-scale screening. Frontiers in Microbiology. 2022,13: 1022054. doi: 10.3389/fmicb.2022.1022054
(2) Chengkun Liu, Kailun Shi, Keliang Lyu, Dongwu Liu, Xue Wang (通讯作者). The toxicity of neodymium and genome-scale genetic screen of neodymium-sensitive gene deletion mutations in the yeast Saccharomyces cerevisiae. Environmental Science and Pollution Research. 2022(29): 41439–41454.(SCI收录)
(3) Keliang Lyu, Kailun Shi, Chengkun Liu, Zhiwen Lyu, Dongwu Liu, Xue Wang (通讯作者). The sensitive genes in response to various metal ion stresses in the yeast Saccharomyces cerevisiae. Protein&Peptide Letters. 2022(29): 231-241.(SCI收录)
2021
(1) Kailun Shi, Chengkun Liu, Dongwu Liu, Keliang Lyu, Jie Chen, Xue Wang (通讯作者). The accumulation and effect of rare earth element neodymium on the root of rice seedlings. Environmental Science and Pollution Research, 2021. 28: 48656–48665.(SCI收录)
(2) Kailun Shi, Chengkun Liu, Keliang Lyu, Jie Chen, Xue Wang (通讯作者). The Bioaccumulation and Detoxification Mechanism of Neodymium on the Shoot of Rice Seedlings. American Journal of Biochemistry and Biotechnology, 2021, 17(2): 140-147.(EI收录)
2019及之前
[1] Caiyun Zhang, Dongwu Liu, Kailun Shi, Chengkun Liu, Keliang Lyu, Jie Chen, Xue Wang(通讯作者). Gadolinium accumulation, distribution, chemical forms, and influence on the growth of rice seedlings. Ecotoxicology and Environmental Safety, 2019, 179: 265-271. ( SCI收录)
[2] Shengnan Zheng, Caiyun Zhang, kailun Shi, Jinxiao Wang, Guanjun Sun, Qiaochu Hu, Fengyun Zhao, Xue Wang (通讯作者). Bioaccumulation, subcellular distribution and chemical forms of yttrium in rice seedling. Journal of Rare Earths, 2018, 36: 331-336. ( SCI收录)
[3] Xue Wang, Dongwu Liu. Integration of cerium chemical forms and subcellular distribution to understand cerium tolerance mechanism in the rice seedlings. Environmental Science and Pollution Research. 2017, 24(19): (SCI 收录)
[4] Dongwu Liu, Shengnan Zheng, Xue Wang (通讯作者) . Lanthanum regulates the reactive oxygen species in the roots of rice seedlings. Scientific Reports, 2016, 31860: 1-7 DOI: 10.1038/srep31860| . (SCI 收录)
[5] D. Liu,X. Wang (通讯作者), X. Zhang, Z. Gao. Effects of lanthanum on growth and accumulation in roots of rice seedlings. Plant, Soil and Environment, 2013, 59(5): 196–200.( SCI 收录)
[6] Xue Wang, Yousheng Lin , Dongwu Liu , Hengjian Xu , Tao Liu, Fengyun Zhao*. Cerium toxicity, uptake and translocation in Arabidopsis thaliana seedlings. Journal of Rare Earths, 30(6), 579-585, 2012.( SCI收录)
[7] Dongwu Liu, Xue Wang (通讯作者), Yousheng Lin, Zhiwei Chen, Hongzhi Xu, Lina Wang. The effects of cerium on the growth and some antioxidant metabolisms in rice seedlings. Environmental Science and Pollution Research, 19(8), 3282-3291,
2012.( SCI收录)
[8] Dongwu Liu, Xue Wang (通讯作者), Zhiwei Chen. Effects of rare earth elements and REE-binding proteins on physiological responses in plants. Protein and Peptide Letters, 19(2), 198-202, 2012.( SCI收录)
[9] Dongwu Liu, Yousheng Lin, Xue Wang ( 通 讯 作 者 ). Effects of lanthanum on growth, element uptake, and oxidative stress in rice seedlings. Journal of Plant Nutrition and Soil Science, 175(6), 907-911, 2012.( SCI收录)
[10] Dongwu Liu, Xue Wang (通讯作者), Xiaohui Chen, Yousheng Lin, Zhiwei Chen, Hongzhi Xu. Effects of lanthanum on the change of calcium level in the root cells of rice. Communications In Soil Science and Plant Analysis, 43(15), 1994-2003, 2012. ( SCI收录) .
[11] Xue Wang, Guoxin Shi, Qinsong Xu, Chuntao Wang. Toxic effects of lanthanum, cerium, chromium and zinc on Potamogeton malaianus, Journal of Rare Earths, 2005, 23(3): 367-371 ( SCI收录)
[12] Dongwu Liu, Xue Wang (通讯作者), Yousheng Lin, Liying Sun, Zhiwei Chen, Hongzhi Xu. Analysis of the effects of cerium on calcium ion in the protoplasts of Arabidopsis thaliana with confocal microscopy. African Journal of Biotechnology, 10(52), 10781-10785, 2011.( SCI收录) .
[13] Dongwu Liu*, Zhiwei Chen, Peiguo Shi, Xue Wang (通讯作者), Weiwei Cai. Analysis of reactive oxygen species in the guard cell of wheat stoma with confocal microscope. Microscopy Research and Technique, 74(9), 795-798, 2011.( SCI收录)
[14] Yousheng Lin, Zhongfeng Ding, Pan Li, Deqiang Zhao, Jiakai Li, Xue Wang (通讯作者). Physiological and biochemical responses of rice root to La3+, Ce3+ and Zn2+ Stress. Agricultural Science & Technology, 2012, 13(1): 17-20, 107.
[15] Xue Wang, Guoxin Shi, Qinsong Xu,Binjun Xu, Juan Zhao. Lanthanum- and cerium-induced oxidative stress in a submerged Hydrilla verticillata plants, Russian Journal of Plant Physiology.2007, 54(5): 693-697 ( SCI 收录)
[16] Xue Wang, Guoxin Shi, Qinsong Xu, Jinzhao Hu. Exogenous polyamines enhance copper tolerance of Nymphoides peltatum, Journal of Plant Physiology. 2007,164: 1062-1070 ( SCI 收录)
研究生就业:主要就业于中国医学科学研究院、科兴生物、美康生物、荣昌制药等生物技术公司、医药企业或事业单位,从事疫苗、新冠病毒检测试剂盒、癌症诊断试剂盒等研发工作,欢迎莘莘学子加盟我们的研究团队。硕士阶段可推荐到中国食品药品检验研究院、“985”、“211”高校联合培养并继续攻读博士学位!