近日，2020级博士生梁慧慧在SCI一区期刊Ceramics International (IF=5.2) 发表基于共价有机框架衍生的Ni/NiO/C用于无酶电化学葡萄糖传感器构建“Ni/NiO/carbon derived from covalent organic frameworks for enzymatic-free electrochemical glucose sensor”。

原文链接：https://doi.org/10.1016/j.ceramint.2023.10.188

Abstract

An electrochemical enzyme-free glucose sensor based on a novel material with high catalytic performance was constructed. Specifically, a covalent-organic framework (COF_BD) with abundant O,N,O'-metal chelating sites was firstly grown on the surface of SiO₂ sacrificial template and then coordinated with Ni²⁺. Finally, Ni/NiO/cellular carbon foam (Ni/NiO/NC) nanocomposite was obtained by carbonizing the above material and removing the SiO₂ template through NaOH etching. The electrocatalytic performance of Ni/NiO/NC could be adjusted by cavity size of NC and size of Ni/NiO nanoparticles. The enzyme-free glucose sensor based on Ni/NiO/NC showed a low detection limit of 0.2 μM, a wide detection range of 0.6 μM-8.6 mM and a high sensitivity of 76.03 μA mM^-1 cm^-2. Moreover, the paper-based wearable glucose sensor was also implemented and the results exhibited that the detection limit was 0.4 μM, the linear range was 1.1 μM-5.2 mM and the sensitivity was 42.38 μA mM^-1 cm^-2. The electrochemical enzyme-free glucose sensor also showed outstanding practical application performance for detection of glucose in real samples of juice, human serum and sweat. The work provided a method to construct novel material with good catalytic performance for sensitive glucose sensor.